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NCT ID: NCT06345716 Not yet recruiting - Renal Colic Clinical Trials

Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic

RC
Start date: April 10, 2024
Phase: Phase 2
Study type: Interventional

This is a prospective, randomized, single-blind study. Patients included in the study after successful treatment of the acute attack were randomized upon discharge from the Emergency Department into three groups: oral paracetamol-tramadol group, oral paracetamol-caffeine group and oral placebo group.

NCT ID: NCT06348420 Not yet recruiting - Clinical trials for Gastroesophageal Reflux Disease

Anti-reflux Mucosal Valvuloplasty Versus PPIs for GERD Treatment

ARMV
Start date: April 10, 2024
Phase: N/A
Study type: Interventional

The study objective is to evaluate the relative merits, safety and effectiveness of Anti-reflux mucosal valvuloplasty (ARMV) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs).

NCT ID: NCT06349005 Not yet recruiting - Videolaryngoscopy Clinical Trials

Laryngoscopy and Coronary Artery Bypass Graft Surgery

VL
Start date: April 10, 2024
Phase: N/A
Study type: Interventional

In this prospective, randomized, controlled trial, the purpose is to compare Macintosh laryngoscope, EzVision® video laryngoscope, McGrath® video laryngoscope and Storz® video laryngoscope in terms of hemodynamic response associated with intubation in adult patients undergoing Coronary Artery Bypass Surgery (CABG).

NCT ID: NCT06353633 Not yet recruiting - Clinical trials for Inflammatory Bowel Diseases

The Effect of Exclusion Diet for Crohn's Disease Plus Enteral Nutrition on Children and Adolescents With Crohn's Disease

Start date: April 10, 2024
Phase: N/A
Study type: Interventional

In this study, children and adolescents with active Crohn's disease are placed in two intervention groups, the first group receives only an exclusion diet and the second group receives an exclusion diet plus formula.

NCT ID: NCT06355024 Not yet recruiting - Clinical trials for Triple-negative Breast Cancer

Inosine Reverse Chemo Resistance in Triple Negative Breast Cancer

Start date: April 10, 2024
Phase: Phase 2
Study type: Interventional

This is a Phase II, open-label, single-arm study evaluating the efficacy and safety of combined treatment of Inosine with chemotherapy in mTNBC (triple negative breast cancer) patients who progressed during previous chemotherapy.

NCT ID: NCT06355037 Not yet recruiting - Clinical trials for Triple-negative Breast Cancer

Dasatinib Combined With Quercetin to Reverse Chemo Resistance in Triple Negative Breast Cancer

Start date: April 10, 2024
Phase: Phase 2
Study type: Interventional

This is a Phase II, open-label, single-arm study evaluating the efficacy and safety of combined treatment of dasatinib, quercetin with chemotherapy in mTNBC (triple negative breast cancer) patients who progressed during previous chemotherapy.

NCT ID: NCT06356285 Not yet recruiting - Clinical trials for Antimicrobial Resistance

Testing New Ways to Name Antimicrobial Resistance

Start date: April 10, 2024
Phase: N/A
Study type: Interventional

This study aims to investigate the public's views on antibiotics and the impact of different ways to name the potential consequences of antibiotics not working in the future. It is known that current ways to name this don't resonate well with the public, and the study team have worked with members of the public through focus groups and community workshops to develop new ways of describing this in a process of co-design. This study aims to test four different ways of presenting this potential crisis to the public, some of which are new communication strategies designed by the public themselves, to evaluate which are the most memorable and investigate the impact on behaviour change. Adults aged over 18, living in the United Kingdom, who have already signed up to a market panel research company will be eligible to participate in this study. Participants will be invited to complete a short online survey (this should take around five minutes), advertised to them by the market research panel they have already signed up to. This survey is completely anonymous, and contains some multiple-choice questions, and some that require a short free text response. At the start of the survey one of the four ways to name AMR will be presented to participants in the form of a poster. This study aims to result in an improved understanding regarding the general public's understanding of antibiotic use and investigate the impact of communication on behaviour change. The data from this study may be used to inform future public health campaigns on this topic and improve the use of antibiotics. This study will be conducted online using the Predictiv platform, an online platform built by the Behavioural Insights Team. The study is being run in collaboration between the Behavioural Insights Team and the Institute of Global Health Innovation at Imperial College London. Is it anticipated that the survey will open in April 2024 and be open until recruitment of 4000 participants is complete. This is expected to take 4-6 weeks.

NCT ID: NCT06359366 Not yet recruiting - Clinical trials for Pelvic Floor Disorders

Perineal Massage Combined With Hip Joint Training

Start date: April 10, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if perineal massage combined with hip joint training works to improve pelvic function (urinary incontinence, constipation and hip motion) in pregnant women. The main questions it aims to answer are: Does the perineal massage combined with hip joint training lower the prevalence of participants who have urinary incontinence and constipation? Does the perineal massage combined with hip joint training improve the flexibility of the hip joint? Researchers will compare an intervention (perineal massage combined with hip joint training) to a comparison(regular training and treatment) to see if the intervention (perineal massage combined with hip joint training) works to improve pelvic function. Participants will: receive the intervention (perineal massage combined with hip joint training ) or regular training and treatment fifth a week at 36 weeks gestation before participants receive first-time intervention, they complete Demographic sociological , ICI-Q-LF, Wexner constipation and hip motion questionnaires

NCT ID: NCT06359418 Not yet recruiting - Obesity Clinical Trials

Acupuncture for Obesity With Prediabetes

Start date: April 10, 2024
Phase: N/A
Study type: Interventional

The clinical trial aims to evaluate the efficacy and safety of acupuncture on weight loss and changes of glucose and lipid metabolism in obese adults with pre-diabetes.

NCT ID: NCT06360250 Not yet recruiting - Clostridium Tetanus Clinical Trials

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation

Start date: April 10, 2024
Phase: Early Phase 1
Study type: Interventional

To evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of the full human anti-tetanus toxin monoclonal antibody A82 / B86 injection combination formulation