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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05514054
Other study ID # 18459
Secondary ID J2J-MC-JZLH2022-
Status Recruiting
Phase Phase 3
First received
Last updated
Start date October 4, 2022
Est. completion date March 15, 2032

Study information

Verified date May 2024
Source Eli Lilly and Company
Contact There may be multiple sites in this clinical trial. 1-877-CTLILL
Phone 1-317-615-4559
Email ClinicalTrials.gov@lilly.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.


Recruitment information / eligibility

Status Recruiting
Enrollment 6000
Est. completion date March 15, 2032
Est. primary completion date October 15, 2027
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis. - Participants must have received at least 24 months but not more than 60 months of any adjuvant ET, from time of adjuvant ET initiation. - Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor. - Must have an increased risk of disease recurrence based on clinical-pathological risk features. - Have a Performance Status of 0 or 1 on the Eastern Cooperative Oncology Group scale. - Have adequate organ function. Exclusion Criteria: - Have any evidence of metastatic disease (including contralateral ALN) or inflammatory breast cancer at primary breast cancer diagnosis. - Participants with more than a 6-month consecutive gap in therapy during the course of prior adjuvant ET. - Participants who have completed or discontinued prior adjuvant ET >6 months prior to screening. - Participants with a history of previous breast cancer are excluded, with the exception of ipsilateral DCIS treated by locoregional therapy alone =5 years ago. - Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 180 days after the last dose of study intervention. - Participant has previously received ET of any duration for breast cancer prevention (tamoxifen or AIs) or raloxifene. - Participants with a history of any other cancer. - Have serious preexisting medical conditions that, in the judgment of the investigator, would preclude participation in this study.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Imlunestrant
Administered orally.
Tamoxifen
Administered per local approved label.
Anastrozole
Administered per local approved label.
Letrozole
Administered per local approved label.
Exemestane
Administered per local approved label.

Locations

Country Name City State
Argentina Centro de Oncología e Investigación de Buenos Aires Berazategui Buenos Aires
Argentina Centro Oncologico Korben Buenos Aires
Argentina CIPREC Buenos Aires Ciudad Autónoma De Buenos Aires
Argentina Fundación Respirar Buenos Aires
Argentina Investigaciones Clinicas Moleculares (ICM) Buenos Aires
Argentina Mautalen Salud e Investigación Buenos Aires Ciudad Autónoma De Buenos Aires
Argentina Clinica Adventista Belgrano Caba Ciudad Autónoma De Buenos Aires
Argentina Fundación Cenit Para La Investigación En Neurociencias Caba Ciudad Autónoma De Buenos Aire
Argentina Centro Medico Privado CEMAIC Capital Córdoba
Argentina Alexander Fleming Ciudad Autónoma de Buenos Aire Buenos Aires
Argentina Fundación CORI para la Investigación y Prevención del Cáncer La Rioja
Argentina Instituto de Investigaciones Clínicas Mar del Plata Mar del Plata Buenos Aires
Argentina Fundacion Scherbovsky Mendoza
Argentina Instituto Médico Río Cuarto Río Cuarto Córdoba
Argentina Fundacion Estudios Clinicos Rosario Santa Fe
Argentina CER San Juan San Juan
Argentina Instituto San Marcos San Juan
Argentina Centro Medico San Roque San Miguel de Tucumán Tucumán
Argentina Go Centro Medico San Nicolás San Nicolas Buenos Aires
Argentina Clinica Viedma Viedma Río Negro
Australia Ballarat Health Services Ballarat Central Victoria
Australia Box Hill Hospital Box Hill Victoria
Australia Monash Health Clayton Victoria
Australia Coffs Harbour Health Campus Coffs Harbour New South Wales
Australia St Vincent's Hospital Darlinghurst New South Wales
Australia Barwon Health Geelong Victoria
Australia Gosford Hospital Gosford New South Wales
Australia Royal Hobart Hospital Hobart Tasmania
Australia Launceston General Hospital Launceston Tasmania
Australia Liverpool Hospital Liverpool New South Wales
Australia Mackay Base Hospital Mackay Queensland
Australia Maroondah Hospital Melbourne Victoria
Australia Northern Hospital Melbourne Victoria
Australia St Vincent's Hospital Melbourne Victoria
Australia Breast Cancer Research Centre-WA Nedlands Western Australia
Australia Lake Macquarie Private Hospital Newcastle New South Wales
Australia Goulburn Valley Health Shepparton Victoria
Australia Gold Coast University Hospital Southport Queensland
Australia Mater Hospital Sydney Sydney New South Wales
Australia Royal Darwin Hospital Tiwi Northern Territory
Australia The Townsville Hospital Townsville Queensland
Australia Hervey Bay Hospital Urraween Queensland
Australia The Queen Elizabeth Hospital Woodville South Australia
Austria Medizinische Universität Graz Graz Steiermark
Austria Uniklinikum Salzburg Salzburg
Austria Private Practice - Dr. Hubalek Schwaz Tirol
Austria Franziskus Spital GmbH Vienna Wien
Austria Klinik Hietzing Vienna Wien
Austria Medizinische Universität Wien Vienna Wien
Austria Medizinische Universität Wien Wien WienWien
Belgium Institut Jules Bordet Anderlecht Bruxelles-Capitale, Région De
Belgium CHIREC - site delta Auderghem Bruxelles-Capitale, Région De
Belgium CHU Saint-Pierre Brussels Bruxelles-Capitale, Région De
Belgium Cliniques universitaires Saint-Luc Brussels Bruxelles-Capitale, Région De
Belgium Grand Hôpital de Charleroi Charleroi Hainaut
Belgium Jessa Ziekenhuis Hasselt Limburg
Belgium Jan Yperman ziekenhuis Ieper
Belgium AZ Groeninge Campus Kennedylaan Kortrijk West-Vlaanderen
Belgium Groupe Jolimont La Louvière Hainaut
Belgium UZ Leuven Leuven Vlaams-Brabant
Belgium Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman Liège
Belgium CHU UCL Namur/Site Sainte Elisabeth Namur
Belgium Clinique Saint Pierre Ottignies
Belgium AZ Nikolaas Sint-Niklaas Oost-Vlaanderen
Belgium CHR Verviers - La Tourelle Verviers
Brazil Fundação Pio XII - Hospital de Câncer de Barretos Barretos São Paulo
Brazil CTO - Centro de Tratamento Oncológico Belem Pará
Brazil Oncocentro de Minas Gerais Belo Horizonte Minas Gera
Brazil Hospital Sirio Libanes Brasilia
Brazil Centro Integrado de Oncologia de Curitiba Curitiba Paraná
Brazil Centro de Pesquisa Clínica do Instituto do Câncer do Ceará Fortaleza Ceará
Brazil Hospital Araújo Jorge Goiânia Goiás
Brazil ONCOSITE - Centro de Pesquisa Clinica em Oncologia Ijui Rio Grande Do Sul
Brazil Hospital de Cancer de Londrina Londrina Paraná
Brazil Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa Porto Alegre Rio Grande Do Sul
Brazil Hospital Moinhos de Vento Porto Alegre Rio Grande Do Sul
Brazil Hospital São Lucas da PUCRS Porto Alegre Rio Grande Do Sul
Brazil Hospital de Amor Amazônia Porto Velho Rondônia
Brazil Multihemo Recife Pernambuco
Brazil Hospital de Clínicas de Ribeirão Preto Ribeirão Preto São Paulo
Brazil Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA Rio de Janeiro
Brazil Grupo COI - Clínicas Oncológicas Integradas Rio de Janeiro
Brazil Hospital São Lucas de Copacabana Rio de Janeiro
Brazil Instituto Nacional de Câncer - INCA Rio de Janeiro
Brazil Nucleo de Oncologia da Bahia Salvador Bahia
Brazil Faculdade de Medicina do ABC Santo André São Paulo
Brazil Hospital de Base de São José do Rio Preto São José do Rio Preto São Paulo
Brazil A. C. Camargo Cancer Center Sao Paulo São Paulo
Brazil Hospital BP Sao Paulo São Paulo
Brazil Hospital Santa Paula Sao Paulo São Paulo
Brazil Hospital Sírio Libanês Sao Paulo São Paulo
Brazil Instituto D'Or de Pesquisa e Ensino (IDOR) Sao Paulo São Paulo
Brazil Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA São Paulo
Brazil Hospital Alemao Oswaldo Cruz São Paulo
Brazil Icesp - Instituto Do Câncer Do Estado de São Paulo São Paulo
Brazil Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T São Paulo
Brazil Instituto de Ensino e Pesquisa São Lucas São Paulo
Brazil IPITEC São Paulo
Brazil NotreDame Intermedica Saude S.A São Paulo
Brazil Núcleo de Pesquisa Clínica da Rede São Camilo São Paulo
Brazil CEDOES Vitória Espírito Santo
Canada Tom Baker Cancer Center Calgary Alberta
Canada London Regional Cancer Program London Ontario
Canada Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T Montreal Quebec
Canada Jewish General Hospital Montreal Quebec
Canada Centre Hospitalier de l'Université de Montréal Montréal Quebec
Canada Hopital Du Saint-Sacrement Quebec City Quebec
Canada BC Cancer Surrey Surrey British Columbia
Canada Humber River Hospital Toronto Ontario
Canada Sunnybrook Research Institute - Odette Cancer Centre Toronto Ontario
China Affiliated Hospital of Hebei University Baoding Hebei
China Beijing Friendship Hospital Beijing Beijing
China Beijing Hospital Beijing Beijing
China Cancer Hospital Chinese Academy of Medical Science Beijing Beijing
China Peking University People's Hospital Beijing Beijing
China The First Hospital of Jilin University Changchun Jilin
China The Second Hospital of Jilin University Changchun Jilin
China The First People's Hospital of Changde City Changde Hunan
China Hunan Cancer Hospital Changsha Hunan
China Xiangya Hospital Central South University Changsha Hunan
China Sichuan Cancer hospital Chengdu Sichuan
China Deyang City People's Hospital Deyang Sichuan
China Dongguan People's Hospital Dongguan Guangdong
China Shunde Hospital of Southern Medical Univesity Foshan Guangdong
China Fujian Medical University Union Hospital-1 Bingfanglou Fuzhou Fujian
China Fuzhou General hospital of Nanjing Military Command Fuzhou Fujian
China Guangdong Maternity and Child Health Care Hospital Guangzhou Guangdong
China Sun Yat-Sen University Cancer Centre Guangzhou Guangdong
China Hainan General Hospital Haikou Hainan
China The First People's Hospital of Hangzhou Hangzhou Zhejiang
China Zhejiang Provincial People's Hospital Hangzhou Zhejiang
China Huizhou Municipal Central Hospital Huizhou Guangdong
China Jiangmen Center Hospital Jiangmen Guangdong
China Jinan Central Hospital Jinan Shandong
China Jining Medical University - Affiliated Hospital Jining Shandong
China The First Affiliated Hospital of Henan University of Science &Technology Luoyang Henan
China The Third Hospital of Nanchang Nanchang Jiangxi
China Jiangsu Province Hospital Nanjing Jiangsu
China The Second People's Hospital of Neijiang Neijiang Sichuan
China Hwa Mei Hospital University of Chinese Academy of Sciences Ningbo Zhejiang
China Ningbo First Hospital Ningbo Zhejiang
China Fudan University Shanghai Cancer Center Shanghai Shanghai
China Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center Shenzhen Guangdong
China ShenZhen People's Hospital Shenzhen Guangdong
China Shenzhen Second People's Hospital Shenzhen Guangdong
China The First Affiliated Hospital of Soochow University Suzhou Jiangsu
China Tianjin Medical University Cancer Institute and Hospital Tianjing Tianjin
China Xinjiang Medical University Cancer Hospital - Urumqi Urumqi Xinjiang
China Hubei Cancer Hospital Wuhan Hubei
China Renmin Hospital of Wuhan University Wuhan Hubei
China Wuhan Union Hospital Wuhan Hubei
China Wannan Medical College Yijishan Hospital Wuhu Shi Anhui
China The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi
China Xiangyang Central Hospital Xiangyang Hubei
China The Central Hospital of Yongzhou - North Campus Yongzhou Hunan
China The First People's Hospital of Yueyang Yueyang Hunan
China Yuncheng Central Hospital - Eastern Hospital Yuncheng Shi Shanxi
China Central Hospital of Guangdong Provincial Agricutural Reclamation Zhanjiang Guangdong
Czechia Masarykuv onkologicky ustav Brno Brno-mesto
Czechia Nemocnice Horovice Horovice Beroun
Czechia Fakultni nemocnice Hradec Kralove Hradec Kralove
Czechia Fakultni nemocnice Ostrava Ostrava Moravskoslezský Kraj
Czechia Multiscan Pardubice Pardubický Kraj
Czechia Fakultni nemocnice Bulovka Prague Praha 8
Czechia Fakultni Thomayerova nemocnice Prague Praha 4
Czechia Fakultni nemocnice Motol Praha Praha 5
Finland Docrates Syöpäsairaala Helsinki Uusimaa
Finland Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) Helsinki Uusimaa
Finland Keski-Suomen Keskussairaala Jyväskylä
Finland Oulun yliopistollinen sairaala Oulu Pohjois-Pohjanmaa
Finland Tampereen yliopistollinen sairaala Tampere Pirkanmaa
Finland Vaasan Keskussairaala Vaasa Pohjanmaa
France Sainte Catherine Institut du Cancer Avignon Provence Avignon Vaucluse
France Centre Hospitalier de la Côte Basque Bayonne Pyrénées-Atlantiques
France CHU Besançon Besançon Doubs
France Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux Aquitaine
France Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan Brest Bretagne
France Pole Santé République Clermont-Ferrand
France Centre Hospitalier Sud Francilien Corbeil-Essonnes Île-de-France
France Henri Mondor Hospital Créteil Île-de-France
France Polyclinique De Blois La Chaussée-Saint-Victor Centre
France CHD Vendee La Roche-sur-Yon Vendée
France Groupe Hospitalier La Rochelle-Ré-Aunis - Hôpital Saint Louis La Rochelle Charente-Maritime
France Chu Grenoble Alpes La Tronche Isère
France Clinique Victor Hugo Le Mans Le Mans Pays-de-la
France Clinique Francois Chenieux Limoges Haute-Vienne
France Hopital Prive Jean Mermoz Lyon Rhône-Alpes
France Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy Metz Moselle
France Centre Hospitalier Général de Mont de Marsan - Hôpital Layné Mont-de-Marsan Landes
France Centre de Cancérologie du Grand Montpellier Montpellier Languedoc-Roussillon
France Polyclinique de Gentilly Nancy Meurthe-et-Moselle
France Centre Antoine-Lacassagne Nice
France Groupe Hospitalier Diaconesses Croix Saint Simon Paris
France Groupe hospitalier Paris saint Joseph Paris Île-de-France
France Hôpital Européen Georges Pompidou Paris
France Hôpital Saint-Louis Paris
France Hôpital Tenon Paris
France Institut Curie Paris
France Centre Hospitalier de Pau Pau Pyrénées-Atlantiques
France Centre Catalan d'Oncologie Perpignan Pyrénées-Orientales
France Centre Hospitalier Universitaire de Poitiers Poitiers Vienne
France Institut Jean Godinot Reims Marne
France Institut de Cancérologie de l'Ouest Saint Herblain Loire-Atlantique
France Institut Curie - site Saint-Cloud Saint-Cloud Hauts-de-Seine
France Centre Hospitalier Privé Saint-Grégoire Saint-Grégoire
France Centre de cancérologie des Dentellières Valenciennes
France Institut de Cancérologie de Lorraine Alexis Vautrin Vandoeuvre-lès-Nancy Lorraine
Germany Gemeinschaftspraxis hop-augsburg Augsburg Bayern
Germany Universitaetsklinikum Augsburg Augsburg Bayern
Germany Helios Klinikum Berlin-Buch Berlin
Germany Onkologische Schwerpunktpraxis Kurfuerstendamm Berlin
Germany Praxisklinik Krebsheilkunde fur Frauen Berlin
Germany Marienhospital Bottrop Bottrop Nordrhein-Westfalen
Germany Städtisches Klinikum Dessau Dessau Sachsen-Anhalt
Germany Onkologiezentrum Donauwörth Donauwörth Bayern
Germany Kath. St.-Johannes-Gesellschaft Dortmund Dortmund Nordrhein-Westfalen
Germany MVZ Medical Center Düsseldorf GmbH Düsseldorf Nordrhein-Westfalen
Germany Universitaetsklinikum Erlangen Erlangen Bayern
Germany Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung Essen Nordrhein-Westfalen
Germany Agaplesion Markus Krankenhaus Frankfurt Hessen
Germany Universitaetsklinikum Freiburg Freiburg im Breisgau Baden-Württemberg
Germany Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer Friedrichshafen Baden-Württemberg
Germany SRH Wald-Klinikum Gera Gera Thüringen
Germany OSP Göttingen Göttingen
Germany Onkologische Schwerpunktpraxis Heidelberg, Dr. med. Andreas Karcher, Dr. med. Daniel Debatin, Dr. med. Ste -T Heidelberg Baden-Württemberg
Germany St. Anna Hospital Herne Nordrhein-Westfalen
Germany Universitaetsklinikum des Saarlandes Homburg Saarland
Germany Klinikverbund Allgäu gGmbH Kempten Bayern
Germany Universitaetsklinikum Schleswig-Holstein Campus Kiel Kiel Schleswig-Holstein
Germany University Hospital of Cologne Köln Nordrhein-Westfalen
Germany Zentrum fuer ambulante gynaekologische Onkologie (ZAGO) Krefeld Nordrhein-Westfalen
Germany Otto-von-Guericke-Universität Magdeburg Magdeburg Sachsen-Anhalt
Germany Universitätsmedizin Mannheim Mannheim Baden-Württemberg
Germany Institut für Versorgungsforschung Dr. Michael Maasberg, Dr. med. Maria Theresia Keller, Marion Schmitz Mayen
Germany Klinikum der Ludwig-Maximilians-Universitaet Muenchen München Bayern
Germany Klinikum Ernst von Bergmann Potsdam Brandenburg
Germany Oncologianova Recklinghausen Nordrhein-Westfalen
Germany HELIOS Kliniken Schwerin Schwerin Mecklenburg-Vorpommern
Germany Diakonissen-Stiftungs-Krankenhaus Speyer Speyer Rheinland-Pfalz
Germany Robert-Bosch-Krankenhaus Stuttgart Baden-Württemberg
Germany SRH Zentralklinikum Suhl Suhl Thüringen
Germany Klinikum Mutterhaus der Borromäerinnen Trier Rheinland-Pfalz
Germany Universitaetsklinikum Tuebingen Tübingen Baden-Württemberg
Germany Universitaetsklinikum Ulm Ulm Baden-Württemberg
Germany Helios Dr. Horst Schmidt Kliniken Wiesbaden Hessen
Greece Agios Savvas Regional Cancer Hospital Athens Attikí
Greece Alexandra Hospital Athens Attikí
Greece Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T Athens Attikí
Greece Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T Athens Attikí (Region)
Greece Attikon General University Hospital Chaidari Attikí
Greece University General Hospital of Heraklion Heraklion Irakleío
Greece University Hospital of Ioannina Ioannina Ioánnina
Greece University General Hospital of Larissa Larissa Thessalía
Greece General Oncology Hospital of Kifissia "Agioi Anargiroi" Néa Kifisiá Attikí
Greece Olympion General Clinic Patras Acha?a
Greece University Hospital of Patras Patras Acha?a
Greece Agios Loukas Clinic Thessaloniki Kentrikí Makedonía
Greece BioClinic Thessaloniki Thessaloniki Kentrikí Makedonía
Greece Euromedica General Clinic of Thessaloniki Thessaloniki Thessaloníki
Greece European Interbalkan Medical Center Thessaloniki Thessaloníki
Hong Kong Queen Mary Hospital Hksar
Hong Kong Hong Kong United Oncology Centre Hong Kong
Hungary Országos Onkológiai Intézet Budapest
Hungary Uzsoki Utcai Kórház Budapest
Hungary Debreceni Egyetem Klinikai Kozpont Debrecen
Hungary Bacs-Kiskun Varmegyei Oktatokorhaz Kecskemét Bács-Kiskun
Hungary Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház Nyiregyhaza Szabolcs-Szatmár-Bereg
India KD Hospital Ahmedabad Gujarat
India Medstar Speciality Hospital Bangalore Karnataka
India KLES Dr. Prabhakar Kore Hospital & M.R.C Belagave Karnataka
India All India Institute of Medical Sciences Bhubaneswar Odisha
India Postgraduate Institute of Medical Education & Research Chandigarh
India Cancer Institute (WIA) Chennai Tamil Nadu
India Nizam's Institute of Medical Sciences Hyderabad Telangana
India Regency Hospital Kanpur Uttar Prad
India Krishna Institute of Medical Sciences - Karad Karad Maharashtra
India Kolhapur Cancer Centre Private Limited Kolhapur Maharashtra
India Tata Memorial Hospital Mumbai Maharashtra
India Rashtrasant Tukdoji Regional Cancer Hospital Nagpur Maharashtra
India HCG Manavata Cancer Centre Nashik Maharashtra
India Delhi State Cancer Institute New Delhi Delhi
India Grant Medical Foundation - Ruby Hall Clinic Pune Maharashtra
India Lifepoint Multispeciality Hospital Pune Maharashtr
India Regional Cancer Centre - Thiruvananthapuram Thiruvananthapuram Kerala
India Mahatma Gandhi Cancer Hospital and Research Institute Visakhapatnam Andhra Pradesh
Ireland Bon Secours Cork Hospital Cork
Ireland Cork University Hospital Cork
Ireland Beaumont Hospital, Dublin Dublin
Ireland St. James's Hospital Dublin
Ireland St. Vincent's University Hospital Dublin
Ireland UCD School of Medicine Beacon Hospital Dublin
Ireland University College Hospital - Galway Galway Connaught
Ireland Sligo General Hospital Sligo
Ireland Waterford Regional Hospital Waterford
Israel Soroka Medical Center Be'er Sheva HaDarom
Israel Carmel Hospital Haifa ?eifa
Israel Shaare Zedek Medical Center Jerusalem Yerushalayim
Israel Meir Medical Center Kfar Saba HaMerkaz
Israel Rabin Medical Center Petah Tikva HaMerkaz
Israel Sheba Medical Center Ramat Gan HaMerkaz
Israel Sourasky Medical Center Tel Aviv Tell Abib
Israel Yitzhak Shamir Medical Center Zerifin HaMerkaz
Italy Aou Ospedali Riuniti Umberto I Ancona
Italy Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo
Italy IRCCS - AOU di Bologna Bologna Emilia-Romagna
Italy Ospedale Antonio Perrino Brindisi
Italy Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia Candiolo Torino
Italy Azienda Ospedaliera Universitaria Careggi Firenze Toscana
Italy Ospedale San Martino Genova Liguria
Italy Ospedale Generale Provinciale Macerata Macerata
Italy Istituto Europeo di Oncologia IRCCS Milano
Italy Humanitas Istituto Clinico Catanese Misterbianco Catania
Italy Azienda Ospedaliero Universitaria Modena
Italy Ospedale San Gerardo-ASST Monza Monza Lombardia
Italy University of Naples Federico II Naples Campania
Italy Istituto Nazionale Tumori IRCCS Fondazione Pascale Napoli Campania
Italy Istituto Oncologico Veneto IRCCS Padova
Italy Azienda Ospedaliero Universitaria di Parma Parma
Italy Istituto Nazionale Tumori Regina Elena Rome Roma
Italy Humanitas Rozzano Milano
Italy Ospedale San Giovanni Moscati Statte Taranto
Italy Azienda Ospedaliera Santa Maria Terni Terni
Japan Juntendo University Hospital Bunkyo-ku Tokyo
Japan Chiba University Hospital Chiba
Japan Chiba cancer center Chiba-shi Chiba
Japan St. Luke's International Hospital Chuo-ku Tokyo
Japan National Hospital Organization Kyushu Cancer Center Fukuoka
Japan Fukushima Medical University Fukushima
Japan Fukuyama City Hospital Fukuyama Hiroshima
Japan Gifu University Hospital Gifu
Japan Tokai University Hachioji Hospital Hachioji-shi Tokyo
Japan Kansai Medical University Hospital Hirakata Osaka
Japan Hiroshima City Hospital Hiroshima
Japan Hiroshima University Hospital Hiroshima
Japan Shimane University Hospital Izumo Shimane
Japan Sagara Hospital Kagoshima
Japan Kameda Clinic Kamogawa Chiba
Japan Ishikawa Prefectural Central Hospital Kanazawa Ishikawa
Japan St. Marianna University School of Medicine Hospital Kawasaki Kanagawa
Japan Japanese Foundation for Cancer Research Koto Tokyo
Japan Chemotopia - Kumamoto Breast & Gastrointestinal Surgical Hospital Kumamoto
Japan Kumamoto Shinto General Hospital Kumamoto
Japan University Hospital,Kyoto Prefectural University of Medicine Kyoto
Japan Shinshu University Hospital Matsumoto Nagano
Japan National Hospital Organization Shikoku Cancer Center Matsuyama Ehime
Japan Miyazaki Prefectural Miyazaki Hospital Miyazaki
Japan Nagoya City University Hospital Nagoya Aichi
Japan Nagoya University Hospital Nagoya Aichi
Japan Naha Nishi Clinic Naha Okinawa
Japan Niigata Cancer Center Hospital Niigata-shi Hokkaido
Japan Hyogo College of Medicine Nishinomiya Hyogo
Japan Okayama University Hospital Okayama
Japan Nakagami Hospital Okinawa Okinawa
Japan National Hospital Organization - Osaka National Hospital - Institute For Clinical Research Osaka
Japan Gunma Prefectural Cancer Center Otashi Gunma
Japan Kitasato University Hospital Sagamihara Kanagawa
Japan Saitama Red Cross Hospital Saitama
Japan Hokkaido University Hospital Sapporo Hokkaido
Japan National Hospital Organization Hokkaido Cancer Center Sapporo Hokkaido
Japan Tohoku University Hospital Sendai-shi Miyagi
Japan Showa University Hospital Shinagawa Tokyo
Japan Center Hospital of the National Center for Global Health and Medicine Shinjyuku-ku Tokyo
Japan Shizuoka General Hospital Shizuoka
Japan National Hospital Organization Takasaki General Medical Centar Takasaki Gunma
Japan Tokushima University Hospital Tokushima
Japan Tsukuba University Hospital Tsukuba Ibaraki
Japan Kanazawa Medical University Hospital Uchinada Ishikawa
Japan Tochigi Cancer Center Utsunomiya Tochigi
Japan Iwate Medical University Hospital Yahaba-cho, Shiwa-gun Iwate
Japan Kanagawa cancer center Yokohama Kanagawa
Japan Yokohama City University Medical Center Yokohama Kanagawa
Korea, Republic of Dongnam Institute of Radiological and Medical Sciences Busan Pusan-Kwangyokshi
Korea, Republic of Soon Chun Hyang University Cheonan Hospital Cheonan-si Chungcheongnam-do [Chungnam]
Korea, Republic of Chungbuk National University Hospital Cheongju-si Chungcheongbuk-do [Chungbuk]
Korea, Republic of Kyungpook National University Chilgok Hospital Daegu Taegu-Kwangyokshi
Korea, Republic of National Cancer Center Goyang-si Kyonggi-do
Korea, Republic of Yeungnam Univeristy Medical Center Gyeongsan-si Kyongsangbuk-do
Korea, Republic of Inha University Hospital Incheon Incheon-gwangyeoksi [Incheon]
Korea, Republic of Gachon University Gil Medical Center Namdong Incheon-gwangyeoksi [Incheon]
Korea, Republic of Seoul National University Bundang Hospital Seongnam Kyonggi-do
Korea, Republic of CHA Bundang Medical Center, CHA University Seongnam-si Kyonggi-do
Korea, Republic of Asan Medical Center Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Gangnam Severance Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Korea University Anam Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Korea University Guro Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Samsung Medical Center Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Seoul National University Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Severance Hospital, Yonsei University Health System Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of The Catholic Univ. of Korea Seoul St. Mary's Hospital Seoul Seoul-teukbyeolsi [Seoul]
Korea, Republic of Ajou University Hospital Suwon-si Kyonggi-do
Korea, Republic of Ulsan University Hospital Ulsan Ulsan-Kwangyokshi
Mexico Scientia Investigacion Clinica S.C. Chihuahua
Mexico Centro de Estudios de Investigacion Metabolicos y Cardiovasculares Ciudad Madero Tamaulipas
Mexico CIO - Centro de Inmuno-Oncología de Occidente Guadalajara Jalisco
Mexico Clinica de Investigacion en Reumatologia y Obesidad S. C. Guadalajara Jalisco
Mexico Preparaciones Oncológicas S.C. León Guanajuato
Mexico CENEIT Oncológicos. Centro Especializado en Investigación y Tratamientos Oncológicos Mexico City Distrito Federal
Mexico COI Centro Oncologico Internacional S.A.P.I. de C.V. Mexico City Distrito Federal
Mexico Grupo Medico Camino Sc Mexico City Distrito Federal
Mexico Althian Clinical Research Monterrey Nuevo León
Mexico Centro Regiomontano de Investigación Monterrey Nuevo León
Mexico Filios Alta Medicina Monterrey Nuevo León
Mexico Centro de Investigacion Clinica de Oaxaca Oaxaca
Mexico Oaxaca Site Management Organization Oaxaca
Mexico Unidad Médica Onco-hematológica Puebla
Mexico PanAmerican Clinical Research - Querétaro - Avenida Antea Querétaro
Mexico Oncologico Potosino, S.C. San Luis Potosi San Luis Potosí
Mexico Centro Medico Zambrano Hellion San Pedro Garza Garcia Nuevo León
Mexico Hospital Angeles Tijuana Baja California
Mexico Centro Oncologico Estatal ISSEMyM ( COEI ) Toluca
Mexico Centro de Estudios Y Prevencion Del Cancer Tuxtla Gutierrez Chiapas
Netherlands Wilhelmina Ziekenhuis Assen Assen Drenthe
Netherlands Amphia Ziekenhuis, locatie Breda Molengracht Breda Noord-Brabant
Netherlands Reinier de Graaf Ziekenhuis, locatie Delft Delft Zuid-Holland
Netherlands Haga Ziekenhuis locatie Leyweg Den Haag Zuid-Holland
Netherlands Deventer Ziekenhuis Deventer Overijssel
Netherlands Albert Schweitzer Ziekenhuis, locatie Dordwijk Dordrecht Zuid-Holland
Netherlands Ziekenhuisgroep Twente, locatie Almelo Hengelo Overijssel
Netherlands Spaarne Gasthuis - Hoofddorp Hoofddorp Noord-Holland
Netherlands Maastricht UMC+ Maastricht Limburg
Netherlands VieCuri Medisch Centrum, locatie Venlo Venlo Limburg
Netherlands Zaans Medisch Centrum Zaandam Noord-Holland
Poland Szpitale Pomorskie Sp. z o. o. Gdynia Pomorskie
Poland Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie Koszalin Zachodniopomorskie
Poland Salve Medica Lodz Lódzkie
Poland Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego Opole Opolskie
Poland FORMED2 Oswiecim Malopolskie
Poland Mazowiecki Szpital Wojewódzki w Siedlcach Siedlce Mazowieckie
Poland MICS Centrum Medyczne Torun Torun Kujawsko-pomorskie
Poland Luxmed Onkologia sp. z o. o. Warszawa Mazowieckie
Poland Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie Warszawa Mazowieckie
Portugal Hopital Garcia de Orta Almada Setúbal
Portugal Hospital Beatriz Ângelo Lisboa
Portugal Hospital da Luz Lisboa Lisboa
Portugal Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria Lisbon Lisboa
Portugal Champalimaud Foundation Lisbon Lisboa
Portugal Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I Vila Nova de Gaia Porto
Romania C.M.D.T.A. Neomed Brasov Bra?ov
Romania Centrul medical Focus Bucure?ti
Romania Gral Medical Diagnostic Center Bucure?ti
Romania Institutul Oncologic Cluj-Napoca Cluj
Romania Centrul de Oncologie "Sfântul Nectarie" Craiova Dolj
Romania Radiology Therapeutic Center Otopeni Ilfov
Romania Ovidius Clinical Hospital OCH Ovidiu Constan?a
Romania S C Oncocenter Oncologie Clinica S R L Timi?oara Timi?
Singapore National Cancer Centre Singapore Singapore Central Singapore
Singapore Raffles Hospital Singapore Central Singapore
Slovakia Narodny onkologicky ustav Bratislava Bratislavský Kraj
Slovakia Onkologicky Ustav sv. Alzbety Bratislava Bratislavský Kraj
Spain CHUAC-Hospital Teresa Herrera A Coruña A Coruña [La Coruña]
Spain Hospital General Universitario de Alicante Alicante
Spain Hospital Universitario Torrecárdenas Almeria Andalucía
Spain Hospital Infanta Cristina Badajoz
Spain Hospital Clínic de Barcelona Barcelona Catalunya [Cataluña]
Spain Hospital de la Santa Creu i Sant Pau Barcelona Catalunya [Cataluña]
Spain Hospital Quiron Barcelona Barcelona Barcelona [Barcelona]
Spain Hospital Universitari Dexeusa Barcelona Catalunya [Cataluña]
Spain Hospital Universitari Vall d'Hebron Barcelona Barcelona [Barcelona]
Spain Parc de Salut Mar - Hospital del Mar Barcelona Barcelona [Barcelona]
Spain Osi Bilbao-Basurto Bilbao País Vasco
Spain Hospital Universitario de Burgos Burgos
Spain Hospital San Pedro de Alcántara Cáceres Extremadura
Spain Hospital Clínico Universitario Virgen de la Arrixaca El Palmar Murcia, Región De
Spain Hospital Universitario Getafe Getafe Madrid, Comunidad De
Spain Hospital Universitario San Cecilio Granada
Spain Complejo Hospitalario de Jaén Jaen Jaén
Spain Hospital Universitario de Canarias La Laguna Santa Cruz De Tenerife
Spain Hospital Universitario Arnau de Vilanova de Lleida Lleida Lleida [Lérida]
Spain Hospital San Pedro Logroño La Rioja
Spain Hospital Lucus Augusti Lugo Lugo [Lugo]
Spain Hospital Beata María Ana Madrid
Spain Hospital Clinico San Carlos Madrid
Spain Hospital General Universitario Gregorio Marañon Madrid Madrid, Comunidad De
Spain Hospital La Princesa Madrid
Spain Hospital Ruber Internacional Madrid
Spain Hospital Universitario 12 de Octubre Madrid Madrid, Comunidad De
Spain Hospital Universitario Infanta Leonor Madrid Madrid, Comunidad De
Spain Hospital Universitario La Paz Madrid Madrid, Comunidad De
Spain Hospital Universitario Ramón y Cajal Madrid Madrid, Comunidad De
Spain Hospital Mateu Orfila Mahon Balears [Baleares]
Spain H.R.U Málaga - Hospital Materno-infantil Malaga Málaga
Spain Hospital Vithas Málaga Málaga
Spain Hospital Universitari Son Espases Palma Balears [Baleares]
Spain Complejo Hospitalario de Navarra Pamplona Navarra
Spain Hospital Universitari Sant Joan de Reus Reus Tarragona
Spain Hospital Universitari General de Catalunya Sant Cugat del Vallès Barcelona [Barcelona]
Spain Hospital Universitario Nuestra Señora de Candelaria Santa Cruz de Tenerife
Spain Hospital General de Segovia Segovia
Spain Hospital Universitario Virgen Del Rocio Sevilla
Spain Hospital Universitario Virgen Macarena Sevilla
Spain Hospital Universitario de Toledo Toledo
Spain Hospital Clinico de Valencia Valencia Valenciana, Comunitat
Spain Hospital Quirónsalud Valencia Valencia València
Spain Hospital Clínico Universitario de Valladolid Valladolid
Spain Hospital Clínico Universitario Lozano Blesa Zaragoza
Taiwan Changhua Christian Hospital Changhua
Taiwan Taipei Tzu Chi General Hospital New Taipei City
Taiwan Taichung Veterans General Hospital Taichung
Taiwan National Cheng Kung University Hospital Tainan
Taiwan Chi Mei Hospital - Liouying Branch Tainan City Tainan
Taiwan Koo Foundation Sun Yat-Sen Cancer Center Taipei
Taiwan National Taiwan University Hospital Taipei
Taiwan Taipei Veterans General Hospital Taipei City Taipei
Taiwan Chang Gung Medical Foundation-Linkou Branch Taoyuan
Turkey Adana City Hospital Adana
Turkey Adana Medical Park Seyhan Hastanesi Adana
Turkey Hacettepe Universitesi Altindag Ankara
Turkey Ankara Bilkent Sehir Hastanesi Ankara
Turkey Ankara Etlik City Hospital Ankara
Turkey Gulhane Egitim Arastirma Hastanesi Ankara
Turkey Memorial Ankara Hastanesi Ankara
Turkey Akdeniz Universitesi Hastanesi Antalya
Turkey Antalya Egitim ve Arastirma Hastanesi Antalya
Turkey Uludag Universitesi Bursa
Turkey Dicle Üniversitesi Diyarbakir
Turkey Trakya University Edirne
Turkey Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi Gaziantep
Turkey Marmara Universitesi Pendik Egitim Arastirma Hastanesi Istanbul
Turkey TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi Istanbul
Turkey Ege Universitesi Hastanesi Izmir
Turkey zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi Izmir
Turkey Izmir Medical Park Hospital Izmir, Karsiyaka Izmir
Turkey Kocaeli Üniversitesi Kocaeli
Turkey Inönü Üniversitesi Turgut Özal Tip Merkezi Egitim ve Arastirma Hastanesi Malatya
Turkey Mersin University Mersin
Turkey Mugla Sitki Kocman Universitesi Egitim ve Arastirma Hastanesi Mugla Mugla
Turkey Sakarya Training and Research Hospital Sakarya
Turkey Ondokuz Mayis Universitesi Samsun
Turkey Medipol Mega Universite Hastanesi Stanbul Istanbul
United Kingdom Colchester General Hospital Colchester Essex
United Kingdom Hairmyres Hospital East Kilbride, Glasgow Great Brit
United Kingdom Western General Hospital Edinburgh Midlothian
United Kingdom Clatterbridge Cancer Centre - Liverpool Liverpool
United Kingdom St Bartholomew's Hospital London London, City Of
United Kingdom The Christie NHS Foundation Trust Manchester Greater Manchester
United Kingdom Mount Vernon Hospital Northwood Hertfordshire
United Kingdom Derriford Hospital Plymouth Devon
United Kingdom Royal Berkshire Hospital Reading
United Kingdom Lister Hospital Stevenage Hertfordshire
United States USO - New York Oncology Hematology Albany New York
United States New Mexico Oncology Hematology Consultants Ltd. Albuquerque New Mexico
United States University of New Mexico Comprehensive Cancer Center Albuquerque New Mexico
United States AdventHealth Altamonte Springs Altamonte Springs Florida
United States Messino Cancer Center Asheville North Carolina
United States Northside Hospital Atlanta Georgia
United States Winship Cancer Institute, Emory University Atlanta Georgia
United States Augusta University Augusta Georgia
United States Anschutz Cancer Pavilion Aurora Colorado
United States USO - Texas Oncology Austin Texas
United States Sarah Cannon Research Institute Baton Rouge Louisiana
United States UCSF - John Muir Health Cancer Center Berkeley Berkeley California
United States Walter Reed National Military Medical Center Bethesda Maryland
United States St. Luke's University Health Network Bethlehem Pennsylvania
United States Saint Alphonsus Regional Medical Center Boise Idaho
United States Dana-Farber Cancer Institute Boston Massachusetts
United States Massachusetts General Hospital Boston Massachusetts
United States Maimonides Cancer Center Brooklyn New York
United States MD Anderson Cancer Center at Cooper Camden New Jersey
United States Aultman Hospital Canton Ohio
United States University of Virginia Health System Charlottesville Virginia
United States Northwestern Memorial Hospital Chicago Illinois
United States University of Illinois at Chicago Chicago Illinois
United States The Christ Hospital Cancer Center Cincinnati Ohio
United States USO - Oncology Hematology Care Cincinnati Ohio
United States UCHealth Memorial Hospital Colorado Springs Colorado
United States University of Missouri Hospital Columbia Missouri
United States The Mark H Zangmeister Center Columbus Ohio
United States Good Samaritan Regional Medical Center Corvallis Oregon
United States Ochsner Medical Center - Jefferson Highway Covington Louisiana
United States USO - Texas Oncology Dallas Texas
United States USO - Texas Oncology Dallas Texas
United States Mass General/North Shore Cancer Center Danvers Massachusetts
United States USO - Southern Cancer Center Daphne Alabama
United States USO - Texas Oncology Denison Texas
United States USO - Texas Oncology Denton Texas
United States Astera Cancer Care East Brunswick New Jersey
United States M Health Fairview Cancer Clinic -Edina Edina Minnesota
United States William Beaumont Army Medical Center El Paso Texas
United States USO - Oncology Associates of Oregon Eugene Oregon
United States Inova Schar Cancer Institute Fairfax Virginia
United States Southcoast Centers for Cancer Care Fairhaven Massachusetts
United States USO - Texas Oncology Flower Mound Texas
United States New York-Presbyterian Queens Flushing New York
United States Fort Belvoir Community Hospital Fort Belvoir Virginia
United States UCHealth Harmony Fort Collins Colorado
United States Holy Cross Hospital Fort Lauderdale Florida
United States Brooke Army Medical Center Fort Sam Houston Texas
United States John Peter Smith Hospital Fort Worth Texas
United States The Center for Cancer and Blood Disorders Fort Worth Texas
United States USO - Texas Oncology Fort Worth Texas
United States Dana-Farber Cancer Institute - Foxborough Foxboro Massachusetts
United States USO - Texas Oncology Fredericksburg Texas
United States Washington Hospital Healthcare System Fremont California
United States The West Clinic, PLLC dba West Cancer Center Germantown Tennessee
United States Banner MD Anderson Cancer Center Gilbert Arizona
United States USO - Arizona Oncology Associates - HAL Glendale Arizona
United States Banner MD Anderson Cancer Center at North Colorado Medical Center Greeley Colorado
United States St Francis Cancer Center Greenville South Carolina
United States John Theurer Cancer Center at Hackensack University Medical Center Hackensack New Jersey
United States Pontchartrain Cancer Center Hammond Louisiana
United States Memorial Regional Hospital Hollywood Florida
United States Millennium Oncology - Hollywood Hollywood Florida
United States Kaiser Permanente Moanalua Medical Center Honolulu Hawaii
United States Kapiolani Medical Center for Women and Children Honolulu Hawaii
United States USO - Alliance Cancer Specialists, PC Horsham Pennsylvania
United States Clearview Cancer Institute Huntsville Alabama
United States Mayo Clinic in Florida Jacksonville Florida
United States University of Tennessee Medical Center Knoxville Tennessee
United States R.J. Zuckerberg Cancer Center Lake Success New York
United States USO - Rocky Mountain Cancer Centers Lakewood Colorado
United States Memorial Medical Center Las Cruces New Mexico
United States Dartmouth-Hitchcock Medical Center Lebanon New Hampshire
United States Central Maine Medical Center Lewiston Maine
United States Regional Cancer Care Associates Little Silver New Jersey
United States Loma Linda University Cancer Center Loma Linda California
United States Dana-Farber - New Hampshire Oncology/Hematology Londonderry New Hampshire
United States Banner MD Anderson Cancer Center at McKee Medical Center Loveland Colorado
United States Care Access - Marrero Marrero Louisiana
United States USO - Texas Oncology McAllen Texas
United States USO - Texas Oncology McKinney Texas
United States Mercy UC Davis Cancer Center Merced California
United States Alliance for Multispecialty Research, LLC Merriam Kansas
United States Dana-Farber Cancer Institute - Merrimack Valley Methuen Massachusetts
United States Miami Cancer Institute at Baptist Health, Inc. Miami Florida
United States Bon Secours St. Francis Medical Center Midlothian Virginia
United States Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center Milford Massachusetts
United States Perlmutter Cancer Center at NYU Langone Hospital - Long Island Mineola New York
United States Allina Health Cancer Institute Minneapolis Minnesota
United States USO - Minnesota Oncology Hematology Minneapolis Minnesota
United States Infirmary Cancer Care Mobile Alabama
United States Pacific Cancer Care Monterey California
United States Northern Westchester Hospital Mount Kisco New York
United States Sarah Cannon Research Institute Nashville Tennessee
United States Rutgers Cancer Institute of New Jersey New Brunswick New Jersey
United States Yale-New Haven Hospital New Haven Connecticut
United States Ochsner Medical Center - Jefferson Highway New Orleans Louisiana
United States Laura and Isaac Perlmutter Cancer Center New York New York
United States Memorial Sloan Kettering Cancer Center New York New York
United States NYC Health + Hospitals / Bellevue New York New York
United States Mass General Cancer Center at Newton-Wellesley Newton Massachusetts
United States USO - Virginia Oncology Associates Norfolk Virginia
United States Nebraska Methodist Hospital Omaha Nebraska
United States St. Joseph Hospital Orange California
United States University of California, Irvine (UCI) Health - UC Irvine Medical Center Orange California
United States USO - Cancer Care Centers of Brevard Palm Bay Florida
United States Capital Health Medical Center - Hopewell Pennington New Jersey
United States USO - Woodlands Medical Specialists Pensacola Florida
United States Illinois Cancer Care Peoria Illinois
United States Thomas Jefferson University Hospital Philadelphia Pennsylvania
United States Thomas Jefferson University, Aria Jefferson Health Philadelphia Pennsylvania
United States Mayo Clinic in Arizona - Phoenix Phoenix Arizona
United States St. Joseph's Hospital and Medical Center Phoenix Arizona
United States USO - Texas Oncology Plano Texas
United States Miami Cancer Institute - Plantation Plantation Florida
United States Oregon Health and Science University Portland Oregon
United States Lifespan Cancer Institute Providence Rhode Island
United States Queens Medical Associates Queens New York
United States USO - Virginia Cancer Specialists Reston Virginia
United States USO - Oncology & Hematology Associates of Southwest Virginia Roanoke Virginia
United States Mayo Clinic in Rochester, Minnesota Rochester Minnesota
United States University of Rochester - Wilmot Cancer Institute Rochester New York
United States Scott & White Hospital - Round Rock Round Rock Texas
United States University of California Davis (UC Davis) Comprehensive Cancer Center Sacramento California
United States Washington University Saint Louis Missouri
United States Mays Cancer Center San Antonio Texas
United States Kaiser Permanente San Diego Mission Road San Diego California
United States UCSF Medical Center at Mission Bay San Francisco California
United States Zuckerberg San Francisco General Hospital and Trauma Center San Francisco California
United States Candler OncologyMedical Practice Savannah Georgia
United States Phelps Hospital Sleepy Hollow New York
United States Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital South Weymouth Massachusetts
United States Highlands Oncology Group Springdale Arkansas
United States Simmons Cancer Institute at SIU Springfield Illinois
United States Saint Joseph's Medical Center Stockton California
United States SUNY Upstate Medical University Syracuse New York
United States Tampa General Hospital Tampa Florida
United States Baylor Scott & White Medical Center - Temple Temple Texas
United States US Oncology Research Network The Woodlands Texas
United States USO - Compass Oncology Tigard Oregon
United States Mercy Health - St. Vincent Medical Center Toledo Ohio
United States The University of Arizona Cancer Center - North Campus Tucson Arizona
United States USO - Arizona Oncology Associates - HOPE Tucson Arizona
United States USO - Texas Oncology Tyler Texas
United States Georgetown University Medical Center Washington District of Columbia
United States MedStar Washington Hospital Center Washington District of Columbia
United States USO - Texas Oncology Webster Texas
United States Clinical Research Alliance Westbury New York
United States The University of Kansas Cancer Center - Westwood Westwood Kansas
United States Asplundh Cancer Pavilion Willow Grove Pennsylvania
United States University of Massachusetts Medical School Worcester Massachusetts
United States York Hospital York Maine
United States St. Elizabeth Youngstown Hospital Youngstown Ohio

Sponsors (1)

Lead Sponsor Collaborator
Eli Lilly and Company

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Canada,  China,  Czechia,  Finland,  France,  Germany,  Greece,  Hong Kong,  Hungary,  India,  Ireland,  Israel,  Italy,  Japan,  Korea, Republic of,  Mexico,  Netherlands,  Poland,  Portugal,  Romania,  Singapore,  Slovakia,  Spain,  Taiwan,  Turkey,  United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Invasive Disease-Free Survival (IDFS) IDFS excluding second non-breast primary invasive cancers Randomization to recurrence or death from any cause (up to 10 years)
Secondary Distant Recurrence-Free Survival (DRFS) DRFS Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years)
Secondary Overall Survival (OS) OS Randomization to Death from Any Cause (up to 10 Years)
Secondary Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant PK: steady state plasma concentrations of imlunestrant Year 1, Month 2 to Month 4
Secondary Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess multidimensional quality of life (QOL) in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Physical functioning was measured by items 1 to 5. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). Visit 1 Day 1 up to end of Year 5
Secondary Change from Baseline in the EORTC QLQ-C30 Role Functioning The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Role functioning was measured by items 6 and 7. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). Visit 1 Day 1 up to end of Year 5
Secondary Change from Baseline in the EORTC QLQ-C30 Global QOL The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Global QOL was measured by items 29 and 30. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). Visit 1 Day 1 up to end of Year 5
Secondary Proportion of Time on Study Treatment with High Overall Adverse Event Burden FACT GP5 = Functional Assessment of Cancer Therapy - General Physical Well-being Item 5 (FACT GP5). High overall adverse event burden is defined as a score of 3 or 4 on a 5-point Likert scale. Higher scores represent higher symptom burden. Visit 1 Day 1 up to end of Year 5
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