Breast Neoplasms Clinical Trial
— EMBER-4Official title:
EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.
Status | Recruiting |
Enrollment | 6000 |
Est. completion date | March 15, 2032 |
Est. primary completion date | October 15, 2027 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis. - Participants must have received at least 24 months but not more than 60 months of any adjuvant ET, from time of adjuvant ET initiation. - Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor. - Must have an increased risk of disease recurrence based on clinical-pathological risk features. - Have a Performance Status of 0 or 1 on the Eastern Cooperative Oncology Group scale. - Have adequate organ function. Exclusion Criteria: - Have any evidence of metastatic disease (including contralateral ALN) or inflammatory breast cancer at primary breast cancer diagnosis. - Participants with more than a 6-month consecutive gap in therapy during the course of prior adjuvant ET. - Participants who have completed or discontinued prior adjuvant ET >6 months prior to screening. - Participants with a history of previous breast cancer are excluded, with the exception of ipsilateral DCIS treated by locoregional therapy alone =5 years ago. - Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 180 days after the last dose of study intervention. - Participant has previously received ET of any duration for breast cancer prevention (tamoxifen or AIs) or raloxifene. - Participants with a history of any other cancer. - Have serious preexisting medical conditions that, in the judgment of the investigator, would preclude participation in this study. |
Country | Name | City | State |
---|---|---|---|
Argentina | Centro de Oncología e Investigación de Buenos Aires | Berazategui | Buenos Aires |
Argentina | Centro Oncologico Korben | Buenos Aires | |
Argentina | CIPREC | Buenos Aires | Ciudad Autónoma De Buenos Aires |
Argentina | Fundación Respirar | Buenos Aires | |
Argentina | Investigaciones Clinicas Moleculares (ICM) | Buenos Aires | |
Argentina | Mautalen Salud e Investigación | Buenos Aires | Ciudad Autónoma De Buenos Aires |
Argentina | Clinica Adventista Belgrano | Caba | Ciudad Autónoma De Buenos Aires |
Argentina | Fundación Cenit Para La Investigación En Neurociencias | Caba | Ciudad Autónoma De Buenos Aire |
Argentina | Centro Medico Privado CEMAIC | Capital | Córdoba |
Argentina | Alexander Fleming | Ciudad Autónoma de Buenos Aire | Buenos Aires |
Argentina | Fundación CORI para la Investigación y Prevención del Cáncer | La Rioja | |
Argentina | Instituto de Investigaciones Clínicas Mar del Plata | Mar del Plata | Buenos Aires |
Argentina | Fundacion Scherbovsky | Mendoza | |
Argentina | Instituto Médico Río Cuarto | Río Cuarto | Córdoba |
Argentina | Fundacion Estudios Clinicos | Rosario | Santa Fe |
Argentina | CER San Juan | San Juan | |
Argentina | Instituto San Marcos | San Juan | |
Argentina | Centro Medico San Roque | San Miguel de Tucumán | Tucumán |
Argentina | Go Centro Medico San Nicolás | San Nicolas | Buenos Aires |
Argentina | Clinica Viedma | Viedma | Río Negro |
Australia | Ballarat Health Services | Ballarat Central | Victoria |
Australia | Box Hill Hospital | Box Hill | Victoria |
Australia | Monash Health | Clayton | Victoria |
Australia | Coffs Harbour Health Campus | Coffs Harbour | New South Wales |
Australia | St Vincent's Hospital | Darlinghurst | New South Wales |
Australia | Barwon Health | Geelong | Victoria |
Australia | Gosford Hospital | Gosford | New South Wales |
Australia | Royal Hobart Hospital | Hobart | Tasmania |
Australia | Launceston General Hospital | Launceston | Tasmania |
Australia | Liverpool Hospital | Liverpool | New South Wales |
Australia | Mackay Base Hospital | Mackay | Queensland |
Australia | Maroondah Hospital | Melbourne | Victoria |
Australia | Northern Hospital | Melbourne | Victoria |
Australia | St Vincent's Hospital | Melbourne | Victoria |
Australia | Breast Cancer Research Centre-WA | Nedlands | Western Australia |
Australia | Lake Macquarie Private Hospital | Newcastle | New South Wales |
Australia | Goulburn Valley Health | Shepparton | Victoria |
Australia | Gold Coast University Hospital | Southport | Queensland |
Australia | Mater Hospital Sydney | Sydney | New South Wales |
Australia | Royal Darwin Hospital | Tiwi | Northern Territory |
Australia | The Townsville Hospital | Townsville | Queensland |
Australia | Hervey Bay Hospital | Urraween | Queensland |
Australia | The Queen Elizabeth Hospital | Woodville | South Australia |
Austria | Medizinische Universität Graz | Graz | Steiermark |
Austria | Uniklinikum Salzburg | Salzburg | |
Austria | Private Practice - Dr. Hubalek | Schwaz | Tirol |
Austria | Franziskus Spital GmbH | Vienna | Wien |
Austria | Klinik Hietzing | Vienna | Wien |
Austria | Medizinische Universität Wien | Vienna | Wien |
Austria | Medizinische Universität Wien | Wien | WienWien |
Belgium | Institut Jules Bordet | Anderlecht | Bruxelles-Capitale, Région De |
Belgium | CHIREC - site delta | Auderghem | Bruxelles-Capitale, Région De |
Belgium | CHU Saint-Pierre | Brussels | Bruxelles-Capitale, Région De |
Belgium | Cliniques universitaires Saint-Luc | Brussels | Bruxelles-Capitale, Région De |
Belgium | Grand Hôpital de Charleroi | Charleroi | Hainaut |
Belgium | Jessa Ziekenhuis | Hasselt | Limburg |
Belgium | Jan Yperman ziekenhuis | Ieper | |
Belgium | AZ Groeninge Campus Kennedylaan | Kortrijk | West-Vlaanderen |
Belgium | Groupe Jolimont | La Louvière | Hainaut |
Belgium | UZ Leuven | Leuven | Vlaams-Brabant |
Belgium | Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman | Liège | |
Belgium | CHU UCL Namur/Site Sainte Elisabeth | Namur | |
Belgium | Clinique Saint Pierre | Ottignies | |
Belgium | AZ Nikolaas | Sint-Niklaas | Oost-Vlaanderen |
Belgium | CHR Verviers - La Tourelle | Verviers | |
Brazil | Fundação Pio XII - Hospital de Câncer de Barretos | Barretos | São Paulo |
Brazil | CTO - Centro de Tratamento Oncológico | Belem | Pará |
Brazil | Oncocentro de Minas Gerais | Belo Horizonte | Minas Gera |
Brazil | Hospital Sirio Libanes | Brasilia | |
Brazil | Centro Integrado de Oncologia de Curitiba | Curitiba | Paraná |
Brazil | Centro de Pesquisa Clínica do Instituto do Câncer do Ceará | Fortaleza | Ceará |
Brazil | Hospital Araújo Jorge | Goiânia | Goiás |
Brazil | ONCOSITE - Centro de Pesquisa Clinica em Oncologia | Ijui | Rio Grande Do Sul |
Brazil | Hospital de Cancer de Londrina | Londrina | Paraná |
Brazil | Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa | Porto Alegre | Rio Grande Do Sul |
Brazil | Hospital Moinhos de Vento | Porto Alegre | Rio Grande Do Sul |
Brazil | Hospital São Lucas da PUCRS | Porto Alegre | Rio Grande Do Sul |
Brazil | Hospital de Amor Amazônia | Porto Velho | Rondônia |
Brazil | Multihemo | Recife | Pernambuco |
Brazil | Hospital de Clínicas de Ribeirão Preto | Ribeirão Preto | São Paulo |
Brazil | Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA | Rio de Janeiro | |
Brazil | Grupo COI - Clínicas Oncológicas Integradas | Rio de Janeiro | |
Brazil | Hospital São Lucas de Copacabana | Rio de Janeiro | |
Brazil | Instituto Nacional de Câncer - INCA | Rio de Janeiro | |
Brazil | Nucleo de Oncologia da Bahia | Salvador | Bahia |
Brazil | Faculdade de Medicina do ABC | Santo André | São Paulo |
Brazil | Hospital de Base de São José do Rio Preto | São José do Rio Preto | São Paulo |
Brazil | A. C. Camargo Cancer Center | Sao Paulo | São Paulo |
Brazil | Hospital BP | Sao Paulo | São Paulo |
Brazil | Hospital Santa Paula | Sao Paulo | São Paulo |
Brazil | Hospital Sírio Libanês | Sao Paulo | São Paulo |
Brazil | Instituto D'Or de Pesquisa e Ensino (IDOR) | Sao Paulo | São Paulo |
Brazil | Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA | São Paulo | |
Brazil | Hospital Alemao Oswaldo Cruz | São Paulo | |
Brazil | Icesp - Instituto Do Câncer Do Estado de São Paulo | São Paulo | |
Brazil | Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T | São Paulo | |
Brazil | Instituto de Ensino e Pesquisa São Lucas | São Paulo | |
Brazil | IPITEC | São Paulo | |
Brazil | NotreDame Intermedica Saude S.A | São Paulo | |
Brazil | Núcleo de Pesquisa Clínica da Rede São Camilo | São Paulo | |
Brazil | CEDOES | Vitória | Espírito Santo |
Canada | Tom Baker Cancer Center | Calgary | Alberta |
Canada | London Regional Cancer Program | London | Ontario |
Canada | Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T | Montreal | Quebec |
Canada | Jewish General Hospital | Montreal | Quebec |
Canada | Centre Hospitalier de l'Université de Montréal | Montréal | Quebec |
Canada | Hopital Du Saint-Sacrement | Quebec City | Quebec |
Canada | BC Cancer Surrey | Surrey | British Columbia |
Canada | Humber River Hospital | Toronto | Ontario |
Canada | Sunnybrook Research Institute - Odette Cancer Centre | Toronto | Ontario |
China | Affiliated Hospital of Hebei University | Baoding | Hebei |
China | Beijing Friendship Hospital | Beijing | Beijing |
China | Beijing Hospital | Beijing | Beijing |
China | Cancer Hospital Chinese Academy of Medical Science | Beijing | Beijing |
China | Peking University People's Hospital | Beijing | Beijing |
China | The First Hospital of Jilin University | Changchun | Jilin |
China | The Second Hospital of Jilin University | Changchun | Jilin |
China | The First People's Hospital of Changde City | Changde | Hunan |
China | Hunan Cancer Hospital | Changsha | Hunan |
China | Xiangya Hospital Central South University | Changsha | Hunan |
China | Sichuan Cancer hospital | Chengdu | Sichuan |
China | Deyang City People's Hospital | Deyang | Sichuan |
China | Dongguan People's Hospital | Dongguan | Guangdong |
China | Shunde Hospital of Southern Medical Univesity | Foshan | Guangdong |
China | Fujian Medical University Union Hospital-1 Bingfanglou | Fuzhou | Fujian |
China | Fuzhou General hospital of Nanjing Military Command | Fuzhou | Fujian |
China | Guangdong Maternity and Child Health Care Hospital | Guangzhou | Guangdong |
China | Sun Yat-Sen University Cancer Centre | Guangzhou | Guangdong |
China | Hainan General Hospital | Haikou | Hainan |
China | The First People's Hospital of Hangzhou | Hangzhou | Zhejiang |
China | Zhejiang Provincial People's Hospital | Hangzhou | Zhejiang |
China | Huizhou Municipal Central Hospital | Huizhou | Guangdong |
China | Jiangmen Center Hospital | Jiangmen | Guangdong |
China | Jinan Central Hospital | Jinan | Shandong |
China | Jining Medical University - Affiliated Hospital | Jining | Shandong |
China | The First Affiliated Hospital of Henan University of Science &Technology | Luoyang | Henan |
China | The Third Hospital of Nanchang | Nanchang | Jiangxi |
China | Jiangsu Province Hospital | Nanjing | Jiangsu |
China | The Second People's Hospital of Neijiang | Neijiang | Sichuan |
China | Hwa Mei Hospital University of Chinese Academy of Sciences | Ningbo | Zhejiang |
China | Ningbo First Hospital | Ningbo | Zhejiang |
China | Fudan University Shanghai Cancer Center | Shanghai | Shanghai |
China | Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center | Shenzhen | Guangdong |
China | ShenZhen People's Hospital | Shenzhen | Guangdong |
China | Shenzhen Second People's Hospital | Shenzhen | Guangdong |
China | The First Affiliated Hospital of Soochow University | Suzhou | Jiangsu |
China | Tianjin Medical University Cancer Institute and Hospital | Tianjing | Tianjin |
China | Xinjiang Medical University Cancer Hospital - Urumqi | Urumqi | Xinjiang |
China | Hubei Cancer Hospital | Wuhan | Hubei |
China | Renmin Hospital of Wuhan University | Wuhan | Hubei |
China | Wuhan Union Hospital | Wuhan | Hubei |
China | Wannan Medical College Yijishan Hospital | Wuhu Shi | Anhui |
China | The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an | Shaanxi |
China | Xiangyang Central Hospital | Xiangyang | Hubei |
China | The Central Hospital of Yongzhou - North Campus | Yongzhou | Hunan |
China | The First People's Hospital of Yueyang | Yueyang | Hunan |
China | Yuncheng Central Hospital - Eastern Hospital | Yuncheng Shi | Shanxi |
China | Central Hospital of Guangdong Provincial Agricutural Reclamation | Zhanjiang | Guangdong |
Czechia | Masarykuv onkologicky ustav | Brno | Brno-mesto |
Czechia | Nemocnice Horovice | Horovice | Beroun |
Czechia | Fakultni nemocnice Hradec Kralove | Hradec Kralove | |
Czechia | Fakultni nemocnice Ostrava | Ostrava | Moravskoslezský Kraj |
Czechia | Multiscan | Pardubice | Pardubický Kraj |
Czechia | Fakultni nemocnice Bulovka | Prague | Praha 8 |
Czechia | Fakultni Thomayerova nemocnice | Prague | Praha 4 |
Czechia | Fakultni nemocnice Motol | Praha | Praha 5 |
Finland | Docrates Syöpäsairaala | Helsinki | Uusimaa |
Finland | Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) | Helsinki | Uusimaa |
Finland | Keski-Suomen Keskussairaala | Jyväskylä | |
Finland | Oulun yliopistollinen sairaala | Oulu | Pohjois-Pohjanmaa |
Finland | Tampereen yliopistollinen sairaala | Tampere | Pirkanmaa |
Finland | Vaasan Keskussairaala | Vaasa | Pohjanmaa |
France | Sainte Catherine Institut du Cancer Avignon Provence | Avignon | Vaucluse |
France | Centre Hospitalier de la Côte Basque | Bayonne | Pyrénées-Atlantiques |
France | CHU Besançon | Besançon | Doubs |
France | Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest | Bordeaux | Aquitaine |
France | Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan | Brest | Bretagne |
France | Pole Santé République | Clermont-Ferrand | |
France | Centre Hospitalier Sud Francilien | Corbeil-Essonnes | Île-de-France |
France | Henri Mondor Hospital | Créteil | Île-de-France |
France | Polyclinique De Blois | La Chaussée-Saint-Victor | Centre |
France | CHD Vendee | La Roche-sur-Yon | Vendée |
France | Groupe Hospitalier La Rochelle-Ré-Aunis - Hôpital Saint Louis | La Rochelle | Charente-Maritime |
France | Chu Grenoble Alpes | La Tronche | Isère |
France | Clinique Victor Hugo Le Mans | Le Mans | Pays-de-la |
France | Clinique Francois Chenieux | Limoges | Haute-Vienne |
France | Hopital Prive Jean Mermoz | Lyon | Rhône-Alpes |
France | Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy | Metz | Moselle |
France | Centre Hospitalier Général de Mont de Marsan - Hôpital Layné | Mont-de-Marsan | Landes |
France | Centre de Cancérologie du Grand Montpellier | Montpellier | Languedoc-Roussillon |
France | Polyclinique de Gentilly | Nancy | Meurthe-et-Moselle |
France | Centre Antoine-Lacassagne | Nice | |
France | Groupe Hospitalier Diaconesses Croix Saint Simon | Paris | |
France | Groupe hospitalier Paris saint Joseph | Paris | Île-de-France |
France | Hôpital Européen Georges Pompidou | Paris | |
France | Hôpital Saint-Louis | Paris | |
France | Hôpital Tenon | Paris | |
France | Institut Curie | Paris | |
France | Centre Hospitalier de Pau | Pau | Pyrénées-Atlantiques |
France | Centre Catalan d'Oncologie | Perpignan | Pyrénées-Orientales |
France | Centre Hospitalier Universitaire de Poitiers | Poitiers | Vienne |
France | Institut Jean Godinot | Reims | Marne |
France | Institut de Cancérologie de l'Ouest | Saint Herblain | Loire-Atlantique |
France | Institut Curie - site Saint-Cloud | Saint-Cloud | Hauts-de-Seine |
France | Centre Hospitalier Privé Saint-Grégoire | Saint-Grégoire | |
France | Centre de cancérologie des Dentellières | Valenciennes | |
France | Institut de Cancérologie de Lorraine Alexis Vautrin | Vandoeuvre-lès-Nancy | Lorraine |
Germany | Gemeinschaftspraxis hop-augsburg | Augsburg | Bayern |
Germany | Universitaetsklinikum Augsburg | Augsburg | Bayern |
Germany | Helios Klinikum Berlin-Buch | Berlin | |
Germany | Onkologische Schwerpunktpraxis Kurfuerstendamm | Berlin | |
Germany | Praxisklinik Krebsheilkunde fur Frauen | Berlin | |
Germany | Marienhospital Bottrop | Bottrop | Nordrhein-Westfalen |
Germany | Städtisches Klinikum Dessau | Dessau | Sachsen-Anhalt |
Germany | Onkologiezentrum Donauwörth | Donauwörth | Bayern |
Germany | Kath. St.-Johannes-Gesellschaft Dortmund | Dortmund | Nordrhein-Westfalen |
Germany | MVZ Medical Center Düsseldorf GmbH | Düsseldorf | Nordrhein-Westfalen |
Germany | Universitaetsklinikum Erlangen | Erlangen | Bayern |
Germany | Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung | Essen | Nordrhein-Westfalen |
Germany | Agaplesion Markus Krankenhaus | Frankfurt | Hessen |
Germany | Universitaetsklinikum Freiburg | Freiburg im Breisgau | Baden-Württemberg |
Germany | Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer | Friedrichshafen | Baden-Württemberg |
Germany | SRH Wald-Klinikum Gera | Gera | Thüringen |
Germany | OSP Göttingen | Göttingen | |
Germany | Onkologische Schwerpunktpraxis Heidelberg, Dr. med. Andreas Karcher, Dr. med. Daniel Debatin, Dr. med. Ste -T | Heidelberg | Baden-Württemberg |
Germany | St. Anna Hospital | Herne | Nordrhein-Westfalen |
Germany | Universitaetsklinikum des Saarlandes | Homburg | Saarland |
Germany | Klinikverbund Allgäu gGmbH | Kempten | Bayern |
Germany | Universitaetsklinikum Schleswig-Holstein Campus Kiel | Kiel | Schleswig-Holstein |
Germany | University Hospital of Cologne | Köln | Nordrhein-Westfalen |
Germany | Zentrum fuer ambulante gynaekologische Onkologie (ZAGO) | Krefeld | Nordrhein-Westfalen |
Germany | Otto-von-Guericke-Universität Magdeburg | Magdeburg | Sachsen-Anhalt |
Germany | Universitätsmedizin Mannheim | Mannheim | Baden-Württemberg |
Germany | Institut für Versorgungsforschung Dr. Michael Maasberg, Dr. med. Maria Theresia Keller, Marion Schmitz | Mayen | |
Germany | Klinikum der Ludwig-Maximilians-Universitaet Muenchen | München | Bayern |
Germany | Klinikum Ernst von Bergmann | Potsdam | Brandenburg |
Germany | Oncologianova | Recklinghausen | Nordrhein-Westfalen |
Germany | HELIOS Kliniken Schwerin | Schwerin | Mecklenburg-Vorpommern |
Germany | Diakonissen-Stiftungs-Krankenhaus Speyer | Speyer | Rheinland-Pfalz |
Germany | Robert-Bosch-Krankenhaus | Stuttgart | Baden-Württemberg |
Germany | SRH Zentralklinikum Suhl | Suhl | Thüringen |
Germany | Klinikum Mutterhaus der Borromäerinnen | Trier | Rheinland-Pfalz |
Germany | Universitaetsklinikum Tuebingen | Tübingen | Baden-Württemberg |
Germany | Universitaetsklinikum Ulm | Ulm | Baden-Württemberg |
Germany | Helios Dr. Horst Schmidt Kliniken | Wiesbaden | Hessen |
Greece | Agios Savvas Regional Cancer Hospital | Athens | Attikí |
Greece | Alexandra Hospital | Athens | Attikí |
Greece | Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T | Athens | Attikí |
Greece | Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T | Athens | Attikí (Region) |
Greece | Attikon General University Hospital | Chaidari | Attikí |
Greece | University General Hospital of Heraklion | Heraklion | Irakleío |
Greece | University Hospital of Ioannina | Ioannina | Ioánnina |
Greece | University General Hospital of Larissa | Larissa | Thessalía |
Greece | General Oncology Hospital of Kifissia "Agioi Anargiroi" | Néa Kifisiá | Attikí |
Greece | Olympion General Clinic | Patras | Acha?a |
Greece | University Hospital of Patras | Patras | Acha?a |
Greece | Agios Loukas Clinic | Thessaloniki | Kentrikí Makedonía |
Greece | BioClinic Thessaloniki | Thessaloniki | Kentrikí Makedonía |
Greece | Euromedica General Clinic of Thessaloniki | Thessaloniki | Thessaloníki |
Greece | European Interbalkan Medical Center | Thessaloniki | Thessaloníki |
Hong Kong | Queen Mary Hospital | Hksar | |
Hong Kong | Hong Kong United Oncology Centre | Hong Kong | |
Hungary | Országos Onkológiai Intézet | Budapest | |
Hungary | Uzsoki Utcai Kórház | Budapest | |
Hungary | Debreceni Egyetem Klinikai Kozpont | Debrecen | |
Hungary | Bacs-Kiskun Varmegyei Oktatokorhaz | Kecskemét | Bács-Kiskun |
Hungary | Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház | Nyiregyhaza | Szabolcs-Szatmár-Bereg |
India | KD Hospital | Ahmedabad | Gujarat |
India | Medstar Speciality Hospital | Bangalore | Karnataka |
India | KLES Dr. Prabhakar Kore Hospital & M.R.C | Belagave | Karnataka |
India | All India Institute of Medical Sciences | Bhubaneswar | Odisha |
India | Postgraduate Institute of Medical Education & Research | Chandigarh | |
India | Cancer Institute (WIA) | Chennai | Tamil Nadu |
India | Nizam's Institute of Medical Sciences | Hyderabad | Telangana |
India | Regency Hospital | Kanpur | Uttar Prad |
India | Krishna Institute of Medical Sciences - Karad | Karad | Maharashtra |
India | Kolhapur Cancer Centre Private Limited | Kolhapur | Maharashtra |
India | Tata Memorial Hospital | Mumbai | Maharashtra |
India | Rashtrasant Tukdoji Regional Cancer Hospital | Nagpur | Maharashtra |
India | HCG Manavata Cancer Centre | Nashik | Maharashtra |
India | Delhi State Cancer Institute | New Delhi | Delhi |
India | Grant Medical Foundation - Ruby Hall Clinic | Pune | Maharashtra |
India | Lifepoint Multispeciality Hospital | Pune | Maharashtr |
India | Regional Cancer Centre - Thiruvananthapuram | Thiruvananthapuram | Kerala |
India | Mahatma Gandhi Cancer Hospital and Research Institute | Visakhapatnam | Andhra Pradesh |
Ireland | Bon Secours Cork Hospital | Cork | |
Ireland | Cork University Hospital | Cork | |
Ireland | Beaumont Hospital, Dublin | Dublin | |
Ireland | St. James's Hospital | Dublin | |
Ireland | St. Vincent's University Hospital | Dublin | |
Ireland | UCD School of Medicine Beacon Hospital | Dublin | |
Ireland | University College Hospital - Galway | Galway | Connaught |
Ireland | Sligo General Hospital | Sligo | |
Ireland | Waterford Regional Hospital | Waterford | |
Israel | Soroka Medical Center | Be'er Sheva | HaDarom |
Israel | Carmel Hospital | Haifa | ?eifa |
Israel | Shaare Zedek Medical Center | Jerusalem | Yerushalayim |
Israel | Meir Medical Center | Kfar Saba | HaMerkaz |
Israel | Rabin Medical Center | Petah Tikva | HaMerkaz |
Israel | Sheba Medical Center | Ramat Gan | HaMerkaz |
Israel | Sourasky Medical Center | Tel Aviv | Tell Abib |
Israel | Yitzhak Shamir Medical Center | Zerifin | HaMerkaz |
Italy | Aou Ospedali Riuniti Umberto I | Ancona | |
Italy | Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Bergamo | |
Italy | IRCCS - AOU di Bologna | Bologna | Emilia-Romagna |
Italy | Ospedale Antonio Perrino | Brindisi | |
Italy | Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia | Candiolo | Torino |
Italy | Azienda Ospedaliera Universitaria Careggi | Firenze | Toscana |
Italy | Ospedale San Martino | Genova | Liguria |
Italy | Ospedale Generale Provinciale Macerata | Macerata | |
Italy | Istituto Europeo di Oncologia IRCCS | Milano | |
Italy | Humanitas Istituto Clinico Catanese | Misterbianco | Catania |
Italy | Azienda Ospedaliero Universitaria | Modena | |
Italy | Ospedale San Gerardo-ASST Monza | Monza | Lombardia |
Italy | University of Naples Federico II | Naples | Campania |
Italy | Istituto Nazionale Tumori IRCCS Fondazione Pascale | Napoli | Campania |
Italy | Istituto Oncologico Veneto IRCCS | Padova | |
Italy | Azienda Ospedaliero Universitaria di Parma | Parma | |
Italy | Istituto Nazionale Tumori Regina Elena | Rome | Roma |
Italy | Humanitas | Rozzano | Milano |
Italy | Ospedale San Giovanni Moscati | Statte | Taranto |
Italy | Azienda Ospedaliera Santa Maria Terni | Terni | |
Japan | Juntendo University Hospital | Bunkyo-ku | Tokyo |
Japan | Chiba University Hospital | Chiba | |
Japan | Chiba cancer center | Chiba-shi | Chiba |
Japan | St. Luke's International Hospital | Chuo-ku | Tokyo |
Japan | National Hospital Organization Kyushu Cancer Center | Fukuoka | |
Japan | Fukushima Medical University | Fukushima | |
Japan | Fukuyama City Hospital | Fukuyama | Hiroshima |
Japan | Gifu University Hospital | Gifu | |
Japan | Tokai University Hachioji Hospital | Hachioji-shi | Tokyo |
Japan | Kansai Medical University Hospital | Hirakata | Osaka |
Japan | Hiroshima City Hospital | Hiroshima | |
Japan | Hiroshima University Hospital | Hiroshima | |
Japan | Shimane University Hospital | Izumo | Shimane |
Japan | Sagara Hospital | Kagoshima | |
Japan | Kameda Clinic | Kamogawa | Chiba |
Japan | Ishikawa Prefectural Central Hospital | Kanazawa | Ishikawa |
Japan | St. Marianna University School of Medicine Hospital | Kawasaki | Kanagawa |
Japan | Japanese Foundation for Cancer Research | Koto | Tokyo |
Japan | Chemotopia - Kumamoto Breast & Gastrointestinal Surgical Hospital | Kumamoto | |
Japan | Kumamoto Shinto General Hospital | Kumamoto | |
Japan | University Hospital,Kyoto Prefectural University of Medicine | Kyoto | |
Japan | Shinshu University Hospital | Matsumoto | Nagano |
Japan | National Hospital Organization Shikoku Cancer Center | Matsuyama | Ehime |
Japan | Miyazaki Prefectural Miyazaki Hospital | Miyazaki | |
Japan | Nagoya City University Hospital | Nagoya | Aichi |
Japan | Nagoya University Hospital | Nagoya | Aichi |
Japan | Naha Nishi Clinic | Naha | Okinawa |
Japan | Niigata Cancer Center Hospital | Niigata-shi | Hokkaido |
Japan | Hyogo College of Medicine | Nishinomiya | Hyogo |
Japan | Okayama University Hospital | Okayama | |
Japan | Nakagami Hospital Okinawa | Okinawa | |
Japan | National Hospital Organization - Osaka National Hospital - Institute For Clinical Research | Osaka | |
Japan | Gunma Prefectural Cancer Center | Otashi | Gunma |
Japan | Kitasato University Hospital | Sagamihara | Kanagawa |
Japan | Saitama Red Cross Hospital | Saitama | |
Japan | Hokkaido University Hospital | Sapporo | Hokkaido |
Japan | National Hospital Organization Hokkaido Cancer Center | Sapporo | Hokkaido |
Japan | Tohoku University Hospital | Sendai-shi | Miyagi |
Japan | Showa University Hospital | Shinagawa | Tokyo |
Japan | Center Hospital of the National Center for Global Health and Medicine | Shinjyuku-ku | Tokyo |
Japan | Shizuoka General Hospital | Shizuoka | |
Japan | National Hospital Organization Takasaki General Medical Centar | Takasaki | Gunma |
Japan | Tokushima University Hospital | Tokushima | |
Japan | Tsukuba University Hospital | Tsukuba | Ibaraki |
Japan | Kanazawa Medical University Hospital | Uchinada | Ishikawa |
Japan | Tochigi Cancer Center | Utsunomiya | Tochigi |
Japan | Iwate Medical University Hospital | Yahaba-cho, Shiwa-gun | Iwate |
Japan | Kanagawa cancer center | Yokohama | Kanagawa |
Japan | Yokohama City University Medical Center | Yokohama | Kanagawa |
Korea, Republic of | Dongnam Institute of Radiological and Medical Sciences | Busan | Pusan-Kwangyokshi |
Korea, Republic of | Soon Chun Hyang University Cheonan Hospital | Cheonan-si | Chungcheongnam-do [Chungnam] |
Korea, Republic of | Chungbuk National University Hospital | Cheongju-si | Chungcheongbuk-do [Chungbuk] |
Korea, Republic of | Kyungpook National University Chilgok Hospital | Daegu | Taegu-Kwangyokshi |
Korea, Republic of | National Cancer Center | Goyang-si | Kyonggi-do |
Korea, Republic of | Yeungnam Univeristy Medical Center | Gyeongsan-si | Kyongsangbuk-do |
Korea, Republic of | Inha University Hospital | Incheon | Incheon-gwangyeoksi [Incheon] |
Korea, Republic of | Gachon University Gil Medical Center | Namdong | Incheon-gwangyeoksi [Incheon] |
Korea, Republic of | Seoul National University Bundang Hospital | Seongnam | Kyonggi-do |
Korea, Republic of | CHA Bundang Medical Center, CHA University | Seongnam-si | Kyonggi-do |
Korea, Republic of | Asan Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Gangnam Severance Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Korea University Anam Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Korea University Guro Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Samsung Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Seoul National University Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Severance Hospital, Yonsei University Health System | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | The Catholic Univ. of Korea Seoul St. Mary's Hospital | Seoul | Seoul-teukbyeolsi [Seoul] |
Korea, Republic of | Ajou University Hospital | Suwon-si | Kyonggi-do |
Korea, Republic of | Ulsan University Hospital | Ulsan | Ulsan-Kwangyokshi |
Mexico | Scientia Investigacion Clinica S.C. | Chihuahua | |
Mexico | Centro de Estudios de Investigacion Metabolicos y Cardiovasculares | Ciudad Madero | Tamaulipas |
Mexico | CIO - Centro de Inmuno-Oncología de Occidente | Guadalajara | Jalisco |
Mexico | Clinica de Investigacion en Reumatologia y Obesidad S. C. | Guadalajara | Jalisco |
Mexico | Preparaciones Oncológicas S.C. | León | Guanajuato |
Mexico | CENEIT Oncológicos. Centro Especializado en Investigación y Tratamientos Oncológicos | Mexico City | Distrito Federal |
Mexico | COI Centro Oncologico Internacional S.A.P.I. de C.V. | Mexico City | Distrito Federal |
Mexico | Grupo Medico Camino Sc | Mexico City | Distrito Federal |
Mexico | Althian Clinical Research | Monterrey | Nuevo León |
Mexico | Centro Regiomontano de Investigación | Monterrey | Nuevo León |
Mexico | Filios Alta Medicina | Monterrey | Nuevo León |
Mexico | Centro de Investigacion Clinica de Oaxaca | Oaxaca | |
Mexico | Oaxaca Site Management Organization | Oaxaca | |
Mexico | Unidad Médica Onco-hematológica | Puebla | |
Mexico | PanAmerican Clinical Research - Querétaro - Avenida Antea | Querétaro | |
Mexico | Oncologico Potosino, S.C. | San Luis Potosi | San Luis Potosí |
Mexico | Centro Medico Zambrano Hellion | San Pedro Garza Garcia | Nuevo León |
Mexico | Hospital Angeles | Tijuana | Baja California |
Mexico | Centro Oncologico Estatal ISSEMyM ( COEI ) | Toluca | |
Mexico | Centro de Estudios Y Prevencion Del Cancer | Tuxtla Gutierrez | Chiapas |
Netherlands | Wilhelmina Ziekenhuis Assen | Assen | Drenthe |
Netherlands | Amphia Ziekenhuis, locatie Breda Molengracht | Breda | Noord-Brabant |
Netherlands | Reinier de Graaf Ziekenhuis, locatie Delft | Delft | Zuid-Holland |
Netherlands | Haga Ziekenhuis locatie Leyweg | Den Haag | Zuid-Holland |
Netherlands | Deventer Ziekenhuis | Deventer | Overijssel |
Netherlands | Albert Schweitzer Ziekenhuis, locatie Dordwijk | Dordrecht | Zuid-Holland |
Netherlands | Ziekenhuisgroep Twente, locatie Almelo | Hengelo | Overijssel |
Netherlands | Spaarne Gasthuis - Hoofddorp | Hoofddorp | Noord-Holland |
Netherlands | Maastricht UMC+ | Maastricht | Limburg |
Netherlands | VieCuri Medisch Centrum, locatie Venlo | Venlo | Limburg |
Netherlands | Zaans Medisch Centrum | Zaandam | Noord-Holland |
Poland | Szpitale Pomorskie Sp. z o. o. | Gdynia | Pomorskie |
Poland | Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie | Koszalin | Zachodniopomorskie |
Poland | Salve Medica | Lodz | Lódzkie |
Poland | Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego | Opole | Opolskie |
Poland | FORMED2 | Oswiecim | Malopolskie |
Poland | Mazowiecki Szpital Wojewódzki w Siedlcach | Siedlce | Mazowieckie |
Poland | MICS Centrum Medyczne Torun | Torun | Kujawsko-pomorskie |
Poland | Luxmed Onkologia sp. z o. o. | Warszawa | Mazowieckie |
Poland | Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie | Warszawa | Mazowieckie |
Portugal | Hopital Garcia de Orta | Almada | Setúbal |
Portugal | Hospital Beatriz Ângelo | Lisboa | |
Portugal | Hospital da Luz Lisboa | Lisboa | |
Portugal | Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria | Lisbon | Lisboa |
Portugal | Champalimaud Foundation | Lisbon | Lisboa |
Portugal | Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I | Vila Nova de Gaia | Porto |
Romania | C.M.D.T.A. Neomed | Brasov | Bra?ov |
Romania | Centrul medical Focus | Bucure?ti | |
Romania | Gral Medical Diagnostic Center | Bucure?ti | |
Romania | Institutul Oncologic | Cluj-Napoca | Cluj |
Romania | Centrul de Oncologie "Sfântul Nectarie" | Craiova | Dolj |
Romania | Radiology Therapeutic Center | Otopeni | Ilfov |
Romania | Ovidius Clinical Hospital OCH | Ovidiu | Constan?a |
Romania | S C Oncocenter Oncologie Clinica S R L | Timi?oara | Timi? |
Singapore | National Cancer Centre Singapore | Singapore | Central Singapore |
Singapore | Raffles Hospital | Singapore | Central Singapore |
Slovakia | Narodny onkologicky ustav | Bratislava | Bratislavský Kraj |
Slovakia | Onkologicky Ustav sv. Alzbety | Bratislava | Bratislavský Kraj |
Spain | CHUAC-Hospital Teresa Herrera | A Coruña | A Coruña [La Coruña] |
Spain | Hospital General Universitario de Alicante | Alicante | |
Spain | Hospital Universitario Torrecárdenas | Almeria | Andalucía |
Spain | Hospital Infanta Cristina | Badajoz | |
Spain | Hospital Clínic de Barcelona | Barcelona | Catalunya [Cataluña] |
Spain | Hospital de la Santa Creu i Sant Pau | Barcelona | Catalunya [Cataluña] |
Spain | Hospital Quiron Barcelona | Barcelona | Barcelona [Barcelona] |
Spain | Hospital Universitari Dexeusa | Barcelona | Catalunya [Cataluña] |
Spain | Hospital Universitari Vall d'Hebron | Barcelona | Barcelona [Barcelona] |
Spain | Parc de Salut Mar - Hospital del Mar | Barcelona | Barcelona [Barcelona] |
Spain | Osi Bilbao-Basurto | Bilbao | País Vasco |
Spain | Hospital Universitario de Burgos | Burgos | |
Spain | Hospital San Pedro de Alcántara | Cáceres | Extremadura |
Spain | Hospital Clínico Universitario Virgen de la Arrixaca | El Palmar | Murcia, Región De |
Spain | Hospital Universitario Getafe | Getafe | Madrid, Comunidad De |
Spain | Hospital Universitario San Cecilio | Granada | |
Spain | Complejo Hospitalario de Jaén | Jaen | Jaén |
Spain | Hospital Universitario de Canarias | La Laguna | Santa Cruz De Tenerife |
Spain | Hospital Universitario Arnau de Vilanova de Lleida | Lleida | Lleida [Lérida] |
Spain | Hospital San Pedro | Logroño | La Rioja |
Spain | Hospital Lucus Augusti | Lugo | Lugo [Lugo] |
Spain | Hospital Beata María Ana | Madrid | |
Spain | Hospital Clinico San Carlos | Madrid | |
Spain | Hospital General Universitario Gregorio Marañon | Madrid | Madrid, Comunidad De |
Spain | Hospital La Princesa | Madrid | |
Spain | Hospital Ruber Internacional | Madrid | |
Spain | Hospital Universitario 12 de Octubre | Madrid | Madrid, Comunidad De |
Spain | Hospital Universitario Infanta Leonor | Madrid | Madrid, Comunidad De |
Spain | Hospital Universitario La Paz | Madrid | Madrid, Comunidad De |
Spain | Hospital Universitario Ramón y Cajal | Madrid | Madrid, Comunidad De |
Spain | Hospital Mateu Orfila | Mahon | Balears [Baleares] |
Spain | H.R.U Málaga - Hospital Materno-infantil | Malaga | Málaga |
Spain | Hospital Vithas Málaga | Málaga | |
Spain | Hospital Universitari Son Espases | Palma | Balears [Baleares] |
Spain | Complejo Hospitalario de Navarra | Pamplona | Navarra |
Spain | Hospital Universitari Sant Joan de Reus | Reus | Tarragona |
Spain | Hospital Universitari General de Catalunya | Sant Cugat del Vallès | Barcelona [Barcelona] |
Spain | Hospital Universitario Nuestra Señora de Candelaria | Santa Cruz de Tenerife | |
Spain | Hospital General de Segovia | Segovia | |
Spain | Hospital Universitario Virgen Del Rocio | Sevilla | |
Spain | Hospital Universitario Virgen Macarena | Sevilla | |
Spain | Hospital Universitario de Toledo | Toledo | |
Spain | Hospital Clinico de Valencia | Valencia | Valenciana, Comunitat |
Spain | Hospital Quirónsalud Valencia | Valencia | València |
Spain | Hospital Clínico Universitario de Valladolid | Valladolid | |
Spain | Hospital Clínico Universitario Lozano Blesa | Zaragoza | |
Taiwan | Changhua Christian Hospital | Changhua | |
Taiwan | Taipei Tzu Chi General Hospital | New Taipei City | |
Taiwan | Taichung Veterans General Hospital | Taichung | |
Taiwan | National Cheng Kung University Hospital | Tainan | |
Taiwan | Chi Mei Hospital - Liouying Branch | Tainan City | Tainan |
Taiwan | Koo Foundation Sun Yat-Sen Cancer Center | Taipei | |
Taiwan | National Taiwan University Hospital | Taipei | |
Taiwan | Taipei Veterans General Hospital | Taipei City | Taipei |
Taiwan | Chang Gung Medical Foundation-Linkou Branch | Taoyuan | |
Turkey | Adana City Hospital | Adana | |
Turkey | Adana Medical Park Seyhan Hastanesi | Adana | |
Turkey | Hacettepe Universitesi | Altindag | Ankara |
Turkey | Ankara Bilkent Sehir Hastanesi | Ankara | |
Turkey | Ankara Etlik City Hospital | Ankara | |
Turkey | Gulhane Egitim Arastirma Hastanesi | Ankara | |
Turkey | Memorial Ankara Hastanesi | Ankara | |
Turkey | Akdeniz Universitesi Hastanesi | Antalya | |
Turkey | Antalya Egitim ve Arastirma Hastanesi | Antalya | |
Turkey | Uludag Universitesi | Bursa | |
Turkey | Dicle Üniversitesi | Diyarbakir | |
Turkey | Trakya University | Edirne | |
Turkey | Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi | Gaziantep | |
Turkey | Marmara Universitesi Pendik Egitim Arastirma Hastanesi | Istanbul | |
Turkey | TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi | Istanbul | |
Turkey | Ege Universitesi Hastanesi | Izmir | |
Turkey | zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi | Izmir | |
Turkey | Izmir Medical Park Hospital | Izmir, Karsiyaka | Izmir |
Turkey | Kocaeli Üniversitesi | Kocaeli | |
Turkey | Inönü Üniversitesi Turgut Özal Tip Merkezi Egitim ve Arastirma Hastanesi | Malatya | |
Turkey | Mersin University | Mersin | |
Turkey | Mugla Sitki Kocman Universitesi Egitim ve Arastirma Hastanesi | Mugla | Mugla |
Turkey | Sakarya Training and Research Hospital | Sakarya | |
Turkey | Ondokuz Mayis Universitesi | Samsun | |
Turkey | Medipol Mega Universite Hastanesi | Stanbul | Istanbul |
United Kingdom | Colchester General Hospital | Colchester | Essex |
United Kingdom | Hairmyres Hospital | East Kilbride, Glasgow | Great Brit |
United Kingdom | Western General Hospital | Edinburgh | Midlothian |
United Kingdom | Clatterbridge Cancer Centre - Liverpool | Liverpool | |
United Kingdom | St Bartholomew's Hospital | London | London, City Of |
United Kingdom | The Christie NHS Foundation Trust | Manchester | Greater Manchester |
United Kingdom | Mount Vernon Hospital | Northwood | Hertfordshire |
United Kingdom | Derriford Hospital | Plymouth | Devon |
United Kingdom | Royal Berkshire Hospital | Reading | |
United Kingdom | Lister Hospital | Stevenage | Hertfordshire |
United States | USO - New York Oncology Hematology | Albany | New York |
United States | New Mexico Oncology Hematology Consultants Ltd. | Albuquerque | New Mexico |
United States | University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico |
United States | AdventHealth Altamonte Springs | Altamonte Springs | Florida |
United States | Messino Cancer Center | Asheville | North Carolina |
United States | Northside Hospital | Atlanta | Georgia |
United States | Winship Cancer Institute, Emory University | Atlanta | Georgia |
United States | Augusta University | Augusta | Georgia |
United States | Anschutz Cancer Pavilion | Aurora | Colorado |
United States | USO - Texas Oncology | Austin | Texas |
United States | Sarah Cannon Research Institute | Baton Rouge | Louisiana |
United States | UCSF - John Muir Health Cancer Center Berkeley | Berkeley | California |
United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
United States | St. Luke's University Health Network | Bethlehem | Pennsylvania |
United States | Saint Alphonsus Regional Medical Center | Boise | Idaho |
United States | Dana-Farber Cancer Institute | Boston | Massachusetts |
United States | Massachusetts General Hospital | Boston | Massachusetts |
United States | Maimonides Cancer Center | Brooklyn | New York |
United States | MD Anderson Cancer Center at Cooper | Camden | New Jersey |
United States | Aultman Hospital | Canton | Ohio |
United States | University of Virginia Health System | Charlottesville | Virginia |
United States | Northwestern Memorial Hospital | Chicago | Illinois |
United States | University of Illinois at Chicago | Chicago | Illinois |
United States | The Christ Hospital Cancer Center | Cincinnati | Ohio |
United States | USO - Oncology Hematology Care | Cincinnati | Ohio |
United States | UCHealth Memorial Hospital | Colorado Springs | Colorado |
United States | University of Missouri Hospital | Columbia | Missouri |
United States | The Mark H Zangmeister Center | Columbus | Ohio |
United States | Good Samaritan Regional Medical Center | Corvallis | Oregon |
United States | Ochsner Medical Center - Jefferson Highway | Covington | Louisiana |
United States | USO - Texas Oncology | Dallas | Texas |
United States | USO - Texas Oncology | Dallas | Texas |
United States | Mass General/North Shore Cancer Center | Danvers | Massachusetts |
United States | USO - Southern Cancer Center | Daphne | Alabama |
United States | USO - Texas Oncology | Denison | Texas |
United States | USO - Texas Oncology | Denton | Texas |
United States | Astera Cancer Care | East Brunswick | New Jersey |
United States | M Health Fairview Cancer Clinic -Edina | Edina | Minnesota |
United States | William Beaumont Army Medical Center | El Paso | Texas |
United States | USO - Oncology Associates of Oregon | Eugene | Oregon |
United States | Inova Schar Cancer Institute | Fairfax | Virginia |
United States | Southcoast Centers for Cancer Care | Fairhaven | Massachusetts |
United States | USO - Texas Oncology | Flower Mound | Texas |
United States | New York-Presbyterian Queens | Flushing | New York |
United States | Fort Belvoir Community Hospital | Fort Belvoir | Virginia |
United States | UCHealth Harmony | Fort Collins | Colorado |
United States | Holy Cross Hospital | Fort Lauderdale | Florida |
United States | Brooke Army Medical Center | Fort Sam Houston | Texas |
United States | John Peter Smith Hospital | Fort Worth | Texas |
United States | The Center for Cancer and Blood Disorders | Fort Worth | Texas |
United States | USO - Texas Oncology | Fort Worth | Texas |
United States | Dana-Farber Cancer Institute - Foxborough | Foxboro | Massachusetts |
United States | USO - Texas Oncology | Fredericksburg | Texas |
United States | Washington Hospital Healthcare System | Fremont | California |
United States | The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee |
United States | Banner MD Anderson Cancer Center | Gilbert | Arizona |
United States | USO - Arizona Oncology Associates - HAL | Glendale | Arizona |
United States | Banner MD Anderson Cancer Center at North Colorado Medical Center | Greeley | Colorado |
United States | St Francis Cancer Center | Greenville | South Carolina |
United States | John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey |
United States | Pontchartrain Cancer Center | Hammond | Louisiana |
United States | Memorial Regional Hospital | Hollywood | Florida |
United States | Millennium Oncology - Hollywood | Hollywood | Florida |
United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
United States | USO - Alliance Cancer Specialists, PC | Horsham | Pennsylvania |
United States | Clearview Cancer Institute | Huntsville | Alabama |
United States | Mayo Clinic in Florida | Jacksonville | Florida |
United States | University of Tennessee Medical Center | Knoxville | Tennessee |
United States | R.J. Zuckerberg Cancer Center | Lake Success | New York |
United States | USO - Rocky Mountain Cancer Centers | Lakewood | Colorado |
United States | Memorial Medical Center | Las Cruces | New Mexico |
United States | Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire |
United States | Central Maine Medical Center | Lewiston | Maine |
United States | Regional Cancer Care Associates | Little Silver | New Jersey |
United States | Loma Linda University Cancer Center | Loma Linda | California |
United States | Dana-Farber - New Hampshire Oncology/Hematology | Londonderry | New Hampshire |
United States | Banner MD Anderson Cancer Center at McKee Medical Center | Loveland | Colorado |
United States | Care Access - Marrero | Marrero | Louisiana |
United States | USO - Texas Oncology | McAllen | Texas |
United States | USO - Texas Oncology | McKinney | Texas |
United States | Mercy UC Davis Cancer Center | Merced | California |
United States | Alliance for Multispecialty Research, LLC | Merriam | Kansas |
United States | Dana-Farber Cancer Institute - Merrimack Valley | Methuen | Massachusetts |
United States | Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida |
United States | Bon Secours St. Francis Medical Center | Midlothian | Virginia |
United States | Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center | Milford | Massachusetts |
United States | Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York |
United States | Allina Health Cancer Institute | Minneapolis | Minnesota |
United States | USO - Minnesota Oncology Hematology | Minneapolis | Minnesota |
United States | Infirmary Cancer Care | Mobile | Alabama |
United States | Pacific Cancer Care | Monterey | California |
United States | Northern Westchester Hospital | Mount Kisco | New York |
United States | Sarah Cannon Research Institute | Nashville | Tennessee |
United States | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey |
United States | Yale-New Haven Hospital | New Haven | Connecticut |
United States | Ochsner Medical Center - Jefferson Highway | New Orleans | Louisiana |
United States | Laura and Isaac Perlmutter Cancer Center | New York | New York |
United States | Memorial Sloan Kettering Cancer Center | New York | New York |
United States | NYC Health + Hospitals / Bellevue | New York | New York |
United States | Mass General Cancer Center at Newton-Wellesley | Newton | Massachusetts |
United States | USO - Virginia Oncology Associates | Norfolk | Virginia |
United States | Nebraska Methodist Hospital | Omaha | Nebraska |
United States | St. Joseph Hospital | Orange | California |
United States | University of California, Irvine (UCI) Health - UC Irvine Medical Center | Orange | California |
United States | USO - Cancer Care Centers of Brevard | Palm Bay | Florida |
United States | Capital Health Medical Center - Hopewell | Pennington | New Jersey |
United States | USO - Woodlands Medical Specialists | Pensacola | Florida |
United States | Illinois Cancer Care | Peoria | Illinois |
United States | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania |
United States | Thomas Jefferson University, Aria Jefferson Health | Philadelphia | Pennsylvania |
United States | Mayo Clinic in Arizona - Phoenix | Phoenix | Arizona |
United States | St. Joseph's Hospital and Medical Center | Phoenix | Arizona |
United States | USO - Texas Oncology | Plano | Texas |
United States | Miami Cancer Institute - Plantation | Plantation | Florida |
United States | Oregon Health and Science University | Portland | Oregon |
United States | Lifespan Cancer Institute | Providence | Rhode Island |
United States | Queens Medical Associates | Queens | New York |
United States | USO - Virginia Cancer Specialists | Reston | Virginia |
United States | USO - Oncology & Hematology Associates of Southwest Virginia | Roanoke | Virginia |
United States | Mayo Clinic in Rochester, Minnesota | Rochester | Minnesota |
United States | University of Rochester - Wilmot Cancer Institute | Rochester | New York |
United States | Scott & White Hospital - Round Rock | Round Rock | Texas |
United States | University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California |
United States | Washington University | Saint Louis | Missouri |
United States | Mays Cancer Center | San Antonio | Texas |
United States | Kaiser Permanente San Diego Mission Road | San Diego | California |
United States | UCSF Medical Center at Mission Bay | San Francisco | California |
United States | Zuckerberg San Francisco General Hospital and Trauma Center | San Francisco | California |
United States | Candler OncologyMedical Practice | Savannah | Georgia |
United States | Phelps Hospital | Sleepy Hollow | New York |
United States | Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital | South Weymouth | Massachusetts |
United States | Highlands Oncology Group | Springdale | Arkansas |
United States | Simmons Cancer Institute at SIU | Springfield | Illinois |
United States | Saint Joseph's Medical Center | Stockton | California |
United States | SUNY Upstate Medical University | Syracuse | New York |
United States | Tampa General Hospital | Tampa | Florida |
United States | Baylor Scott & White Medical Center - Temple | Temple | Texas |
United States | US Oncology Research Network | The Woodlands | Texas |
United States | USO - Compass Oncology | Tigard | Oregon |
United States | Mercy Health - St. Vincent Medical Center | Toledo | Ohio |
United States | The University of Arizona Cancer Center - North Campus | Tucson | Arizona |
United States | USO - Arizona Oncology Associates - HOPE | Tucson | Arizona |
United States | USO - Texas Oncology | Tyler | Texas |
United States | Georgetown University Medical Center | Washington | District of Columbia |
United States | MedStar Washington Hospital Center | Washington | District of Columbia |
United States | USO - Texas Oncology | Webster | Texas |
United States | Clinical Research Alliance | Westbury | New York |
United States | The University of Kansas Cancer Center - Westwood | Westwood | Kansas |
United States | Asplundh Cancer Pavilion | Willow Grove | Pennsylvania |
United States | University of Massachusetts Medical School | Worcester | Massachusetts |
United States | York Hospital | York | Maine |
United States | St. Elizabeth Youngstown Hospital | Youngstown | Ohio |
Lead Sponsor | Collaborator |
---|---|
Eli Lilly and Company |
United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Czechia, Finland, France, Germany, Greece, Hong Kong, Hungary, India, Ireland, Israel, Italy, Japan, Korea, Republic of, Mexico, Netherlands, Poland, Portugal, Romania, Singapore, Slovakia, Spain, Taiwan, Turkey, United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Invasive Disease-Free Survival (IDFS) | IDFS excluding second non-breast primary invasive cancers | Randomization to recurrence or death from any cause (up to 10 years) | |
Secondary | Distant Recurrence-Free Survival (DRFS) | DRFS | Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years) | |
Secondary | Overall Survival (OS) | OS | Randomization to Death from Any Cause (up to 10 Years) | |
Secondary | Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant | PK: steady state plasma concentrations of imlunestrant | Year 1, Month 2 to Month 4 | |
Secondary | Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning | The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess multidimensional quality of life (QOL) in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Physical functioning was measured by items 1 to 5. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). | Visit 1 Day 1 up to end of Year 5 | |
Secondary | Change from Baseline in the EORTC QLQ-C30 Role Functioning | The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Role functioning was measured by items 6 and 7. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). | Visit 1 Day 1 up to end of Year 5 | |
Secondary | Change from Baseline in the EORTC QLQ-C30 Global QOL | The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Global QOL was measured by items 29 and 30. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better). | Visit 1 Day 1 up to end of Year 5 | |
Secondary | Proportion of Time on Study Treatment with High Overall Adverse Event Burden | FACT GP5 = Functional Assessment of Cancer Therapy - General Physical Well-being Item 5 (FACT GP5). High overall adverse event burden is defined as a score of 3 or 4 on a 5-point Likert scale. Higher scores represent higher symptom burden. | Visit 1 Day 1 up to end of Year 5 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT05558917 -
Comparison Between PECS BLOCK 2 vs ESP BLOCK in Ocnologic Breast Surgery
|
N/A | |
Active, not recruiting |
NCT03664778 -
Abbreviated Breast MRI After Cancer Treatment
|
||
Recruiting |
NCT03144622 -
18F-FSPG PET/CT Imaging in Patients With Cancers
|
||
Completed |
NCT05452499 -
Pain Neuroscience Education and Therapeutic Exercise as a Treatment for Breast Cancer Survivors Living With Sequelae
|
N/A | |
Active, not recruiting |
NCT04568902 -
Study of H3B-6545 in Japanese Women With Estrogen Receptor (ER)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer
|
Phase 1 | |
Completed |
NCT02860585 -
Evaluation of Survival in Patients With Metastatic Breast Cancer Receiving High-dose Chemotherapy With Autologous Haematopoietic Stem Cell Transplantation
|
N/A | |
Completed |
NCT04059809 -
Photobiomodulation for Breast Cancer Radiodermatitis
|
Phase 2/Phase 3 | |
Recruiting |
NCT04557449 -
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
|
Phase 1/Phase 2 | |
Completed |
NCT03698942 -
Delphinus SoftVueâ„¢ ROC Reader Study
|
||
Completed |
NCT00092950 -
Exercise in Women at Risk for Breast Cancer
|
Phase 2 | |
Terminated |
NCT04123704 -
Sitravatinib in Metastatic Breast Cancer
|
Phase 2 | |
Not yet recruiting |
NCT02151071 -
The Breast Surgery EnLight and LightPath Imaging System Study
|
Phase 1/Phase 2 | |
Recruiting |
NCT02934360 -
TR(ACE) Assay Clinical Specimen Study
|
N/A | |
Active, not recruiting |
NCT02950064 -
A Study to Determine the Safety of BTP-114 for Treatment in Patients With Advanced Solid Tumors With BRCA Mutations
|
Phase 1 | |
Not yet recruiting |
NCT02876848 -
A Novel E-Health Approach in Optimizing Treatment for Seniors (OPTIMUM Study)
|
N/A | |
Completed |
NCT02931552 -
Nuevo Amanecer II: Translating a Stress Management Program for Latinas
|
N/A | |
Recruiting |
NCT02547545 -
Breast Cancer Chemotherapy Risk Prediction Mathematical Model
|
N/A | |
Completed |
NCT02652975 -
Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium
|
N/A | |
Completed |
NCT02303366 -
Pilot Study of Stereotactic Ablation for Oligometastatic Breast Neoplasia in Combination With the Anti-PD-1 Antibody MK-3475
|
Phase 1 | |
Completed |
NCT02518477 -
Preventive Intervention Against Lymphedema After Breast Cancer Surgery
|
N/A |