Pilot Study of Bisphosphonates for Breast Cancer

Status Terminated

Clinical Trial Summary

The goal of this study is to mechanistically define the potential anticancer activities of the osteoporosis bisphosphonate (BP) drug alendronate, and extend the analysis to learn novel information about the impact of BP on gamma delta (γδ) T cells in breast tissues as well as epithelial breast cell differentiation of high-risk women. To this end, we have designed a BP "window trial" to examine the effect of 1 - 3 weeks administration of alendronate on women at high-risk for breast cancer, at the level of immunosurveillance and mammary epithelial cell differentiation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Breast Neoplasms

Clinical Trial Details

NCT number	NCT02781805
Study type	Interventional
Source	University of Wisconsin, Madison
Contact
Status	Terminated
Phase	Phase 1
Start date	August 5, 2016
Completion date	December 12, 2018

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