Breast Neoplasms Clinical Trial
Official title:
Comparative Analysis of the Efficacies of AT and AC-T Regimens in Neoadjuvant Chemotherapy of Breast Cancer
The purpose of this study is to compare the short-term and long-term efficacies and the safeties of pirarubicin plus docetaxel(AT group) and pirarubicin plus cyclophosphamide followed by docetaxel(AC-T group) in neoadjuvant chemotherapy of breast cancer.
Based on the results of NSABP(National Surgical Adjuvant Breast and Bowel Project) B27
trial, anthracyclines(A) and Taxanes(T) are most commonly recommended in neoadjuvant
chemotherapy of breast cancer.
Pirarubicin is one of anthracyclines and by embedding the DNA double stranded, which
inhibits DNA replication and RNA synthesis, thereby impedes the rapid growth of cancer
cells.
Docetaxel in one of taxanes and by strengthening the tubulin polymerization, inhibiting of
microtubule depolymerization and leading to the formation of stable non functional
microtubule bundles, which destroys mitosis of tumor cells.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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