Controlled Ovarian Stimulation in Newly Diagnosed Breast Cancer PatiEnts (fAMHOPE) — fAMHOPE

Breast Neoplasm Malignant Female Clinical Trial

Official title:
A Multicenter Prospective coHort Study of Controlled Ovarian Stimulation in Newly Diagnosed Breast Cancer PatiEnts (fAMHOPE)

Status Recruiting

Clinical Trial Summary

This is a multicenter hospital-based prospective cohort study conducted in institutions with known expertise in performing oocytes/embryo freezing for fertility preservation. The study aims at refining the understanding of the efficacy and safety of controlled ovarian stimulation with or without letrozole in young women with newly diagnosed breast cancer who are candidates to receive (neo)adjuvant chemotherapy.

Clinical Trial Description

Patients enrolled in this study undergo standard or "random start" ovarian stimulation with Gonadotropins using antagonist protocol before the beginning of chemotherapy. Ovulation is triggered in all patients with a Gonadotropin Releasing Hormone-GnRH agonist. After retrieval, oocytes are denuded and matured oocytes are subjected to fertilization before embryo freezing or direct vitrification. Primary objective is to evaluate the efficacy of performing a controlled ovarian stimulation with or without letrozole in young women with newly diagnosed breast cancer who are candidates to receive (neo)adjuvant chemotherapy in terms of mature oocytes collected. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04289805
Study type	Interventional
Source	Erasme University Hospital
Contact	Isabelle Demeestere, MD,PhD
Phone	003225556592
Email	isabelle.demeestere@ulb.be
Status	Recruiting
Phase	Phase 4
Start date	February 25, 2019
Completion date	January 30, 2029

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05941299` - Clinical Trial to Demonstrate the Safety and Performance of REGENERA Breast Implant in 40-70 Years Old Women Affected by Malignant Breast Lesion Treated by Lumpectomy	N/A
Completed	`NCT04348955` - Interest of Touch-massage in Hospital Day Care
Completed	`NCT05812326` - PD-1 Knockout Anti-MUC1 CAR-T Cells in the Treatment of Advanced Breast Cancer	Phase 1/Phase 2
Recruiting	`NCT04424732` - SBRT for Breast Cancer Oligometastases	N/A
Completed	`NCT03109080` - Olaparib & Radiation Therapy for Patients Triple Negative Breast Cancer (TNBC)	Phase 1
Recruiting	`NCT04198727` - Study of the Impact of DPD Activity on the Efficacy of Capecitabine	N/A
Completed	`NCT03525990` - Study Evaluating the Impact of Electronic Surveys on Patient-physician Communication and Quality of Life in Breast Cancer Patients	N/A
Available	`NCT05134922` - Expanded Access Protocol for Subjects Previously Treated With Gedatolisib in B2151009