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Palbociclib, Letrozole & Venetoclax in ER and BCL-2 Positive Breast Cancer — PALVEN  

Breast Neoplasm Female Clinical Trial

Official title:
A Phase 1b Study of Palbociclib, Letrozole and Venetoclax in ER and BCL-2 Positive Locally Advanced or Metastatic Breast Cancer

Clinical Trial Summary

This study is investigating the combination of palbociclib, letrozole and venetoclax in ER and BCL-2 positive locally advanced or metastatic breast cancer. It is hypothesised that venetoclax may augment the actions of palbociclib and letrozole in these patient groups. The primary objective of the study is to determine the maximum tolerated dose of the combination treatment, which can be used in subsequent studies. The study will also investigate disease response and survival. Participants will receive palbociclib (daily, on days 1-21 of each 28 day cycle), letrozole (daily, on days 1-28 of each 28 day cycle) and venetoclax (daily, on days 1-21 of each 28 day cycle) until the last patient has completed 18 months treatment on the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03900884
Study type Interventional
Source Peter MacCallum Cancer Centre, Australia
Contact Geoffrey Lindeman, MBBS FRACP PhD
Phone +61393452611
Email Geoffrey.Lindeman@petermac.org
Status Recruiting
Phase Phase 1
Start date September 25, 2019
Completion date December 2025
View Details
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