Diagnosis Value of SEMA4C in Breast Cancer

Status Not yet recruiting

Clinical Trial Summary

Breast cancer remains the most common cancer in women worldwide. Early diagnosis can greatly improve the prognosis. To date, imaging examination is still the most important diagnostic and grading tool for breast cancer. Semaphorin4C (SEMA4C) has previously been identified as a highly expressed protein by breast cancer-associated lymphatic endothelial cells (LECs). The study is undertaken to evaluate the diagnostic efficiency of SEMA4C.

Clinical Trial Description

Breast cancer remains the most common cancer in women worldwide, with approximately 1.68 million new cases, and 0.52 million deaths, annually. Meanwhile the incidence of breast cancer continues to increase. Early diagnosis and access to optimum treatment are crucial to reduce mortality associated with breast cancer. Currently, mammography and breast ultrasonography are essential for the detection and diagnosis of disease, and breast magnetic resonance imaging is the choice to estimate the extent of disease and guide appropriate treatment. However, there is no robust biomarkers for early detection of breast cancer. Semaphorin4C (SEMA4C) has been previously identified as a highly expressed protein by breast cancer-associated lymphatic endothelial cells (LECs) using in situ laser capture microdissection of lymphatic vessels, followed by cDNA microarray analysis. Moreover, membrane-bound SEMA4C is cleaved by matrix metalloproteinase (MMPs) to release a soluble form of this protein. Therefore, this prospective project aims to assess the early diagnostic value of SEMA4C as a biomarker for breast cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03662633
Study type	Observational
Source	Tongji Hospital
Contact	Qinglei Gao, MD, PhD
Phone	13871127473
Email	qingleigao@hotmail.com
Status	Not yet recruiting
Phase
Start date	September 1, 2023
Completion date	September 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03980626` - Study on Physical Activity's Relationship With Cancer and Cognition	N/A
Completed	`NCT04329819` - Satisfaction and QUality of Life After Breast REconstruction
Recruiting	`NCT03323346` - Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer	Phase 2
Recruiting	`NCT03900884` - Palbociclib, Letrozole & Venetoclax in ER and BCL-2 Positive Breast Cancer	Phase 1
Completed	`NCT05042999` - The Use of Virtual Reality During Breast Ultrasound-Guided Biopsy Procedures	N/A
Recruiting	`NCT05075512` - The Efficacy and Safety of Anlotinib Combined With Fulvestrant in Patients With Advanced Breast Cancer	Phase 2
Recruiting	`NCT04456855` - Locoregional Surgery of the Primary Tumor in de Novo Stage IV Breast Cancer Patients
Not yet recruiting	`NCT03629509` - BEFORE Decision Aid Implementation Study	N/A
Completed	`NCT04811378` - HaemoCerTM Application in Breast Cancer Surgery	N/A
Completed	`NCT03198442` - Breast PET Feasibility	N/A
Not yet recruiting	`NCT05577442` - Trastuzumab, Pyrotinib Combined With Dalpiciclib and Endocrine Therapy for HR +/HER2 + Advanced Breast Cancer	Phase 2
Enrolling by invitation	`NCT04047823` - Temperature and Injury in Radiotherapy Radiation Skin Injury
Recruiting	`NCT05452213` - Comprehensive Analysis of Spatial, Temporal and Molecular Patterns of Ribociclib Efficacy and Resistance in Advanced Breast Cancer Patients	Phase 4
Recruiting	`NCT05027321` - Efficacy of Preparation in Self-Hypnosis by Anchoring Versus Conversational Hypnosis, Used Alone or Combined, in Patients Undergoing Breast Macrobiopsies	N/A
Recruiting	`NCT04812652` - Digitally Distributed Yoga for Women Treated for Breast Cancer	N/A
Active, not recruiting	`NCT03425838` - Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer	Phase 3
Completed	`NCT05473026` - Grateful Strides Toward Physical Activity and Well-Being for Black Breast Cancer Survivors	N/A
Completed	`NCT04509063` - Investigating Public Enthusiasm for Mammography Screening in Denmark	N/A
Recruiting	`NCT05711030` - Thoracic Paravertebral Block Anesthesia for Breast Cancer Surgery	N/A
Suspended	`NCT03271853` - Thermalogical Analysis of a Cohort of Women and Men Undergoing Mammographic Analysis.	N/A