Myeloprotection With Trilaciclib in Pan-cancer Population

Status Not yet recruiting

Clinical Trial Summary

The goal of this open-label randomized controlled study is to assess the myeloprotective effect of trilaciclib in pan-cancer population. The main questions it aims to answer are: - effect and safety of trilaciclib on myeloprotection in cancer patients receiving paclitaxel plus carboplatin chemotherapy - does trilaciclib 's myeloprotective efficacy in patients receiving the same chemotherapy regimen correlate with tumor type Participants will be randomized 2:1 to the treatment arm of trilaciclib in combination with a paclitaxel and carboplatin-based regimen and the control arm of a paclitaxel and carboplatin-based regimen for at least 6 cycles or until disease progression or intolerable toxicity. Patients in both groups could extend the chemotherapy cycle at the investigator 's discretion depending on the tumor type and in combination with anti-angiogenic/PD-X/anti-HER2 therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Breast Cancer
Cervical Cancer
Endometrial Cancer
Endometrial Neoplasms
Non-Small Cell Lung Cancer
Squamous Cell Carcinoma of Head and Neck

Clinical Trial Details

NCT number	NCT06297811
Study type	Interventional
Source	Sun Yat-sen University
Contact	Ruihua Xu, PhD
Phone	+86-13922206676
Email	xurh@sysucc.org.cn
Status	Not yet recruiting
Phase	Phase 2
Start date	March 1, 2024
Completion date	December 31, 2027

View Details

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