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Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction

Breast Cancer Clinical Trial

Official title:
Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction

Clinical Trial Summary

Neoadjuvant radiotherapy(NART) followed by mastectomy and immediate DIEP flap reconstruction is feasible and technically safe. However, reports of NACT followed immediate implant-based breast reconstruction are rare. Some studies have shown that NART followed immediate implant-based breast reconstruction seems feasible and can be safely attempted. It's well known that radiotherapy after implant-based breast reconstruction have negative effects on implant and cosmetic results. So, investigators conducted a polit study to learn about acute post-surgical complications following skin-sparing mastectomy and immediate implant-based breast reconstruction after NART.

Clinical Trial Description

Radiotherapy after implant-based breast reconstruction have negative effects on implant and cosmetic results, including severe capsular contracture, mastectomy flap necrosis ,reoperation and so on. Postmastectomy radiotherapy( PMRT )is associated with implant reconstruction failure. PRADA study has shown neoadjuvant radiotherapy followed by skin-sparing mastectomy and immediate DIEP flap reconstruction is feasible and technically safe. The investigators assume that neoadjuvant radiotherapy can avoid the negative effects of PMRT on an implant and the capsule of an implant and would lead to better cosmetic results and less complications compared to PMRT. Furthermore, some studies have shown that NART could potentially result in shorter time between diagnosis and treatment completion. So, investigators conducted a polit study to learn about acute post-surgical complications following skin-sparing mastectomy and immediate implant-based breast reconstruction after NART. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05992870
Study type Interventional
Source Hubei Cancer Hospital
Contact Xinhong Wu, MD
Phone +8618602726300
Email 34053889@qq.com
Status Recruiting
Phase N/A
Start date July 8, 2023
Completion date October 31, 2025
View Details
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