Breast Cancer Clinical Trial
Official title:
Prospective Imaging Study of 68Ga-NOTA-NFB in Tumors
The purpose of this study is to assess the safety, biodistribution, dosimetric properties of
the positron emission tomography (PET) radiopharmaceutical agent 68Ga-NOTA-NFB. To
preliminarily evaluate its application in glioma diagnosis.
To assess the application of 68Ga-NOTA-NFB PET/CT in the evaluation of the neoadjuvant
chemotherapy in patients with breast cancer before and after the therapy.
6 healthy volunteers with whole-body PET/CT scans 0, 0.5, 1.0, 2.0, and 3.0 hours after
tracer injection (mean dose, 4.93 ± 0.10 mCi) will be performed. During the imaging period,
1 mL blood samples will be obtained specifically at 1, 3, 5, 10, 30,60, 90, 120, 150, and
180 minutes after the injection, for time-activity curve calculations. The estimated
radiation doses will be calculated by using OLINDA/EXM software.
8-10 patients with glioma will be enrolled for the clinical study of diagnosing glioma, they
will be performed with both 68Ga-NOTA-NFB PET/CT and18F-FDG PET/CT scans before surgery. The
preoperative images are compared and correlated with the pathologically report. Next, the
expression of CXCR4 will be determined by immunohistochemical staining of the resected brain
tumor tissues.
30 patients with breast cancer will be underwent 68Ga-NOTA-NFB PET/CT and18F-FDG PET/CT
scans before and after the neoadjuvant chemotherapy. SUV of lesions before and after therapy
will be contrasted.
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