Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection

Breast Cancer Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02089178
• Other study ID #: 4-2013-0937
• Status: Terminated
• Phase: N/A
• Start date: February 2014
• Est. completion date: December 30, 2014

Study information

• Verified date: December 2014
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 48
• Est. completion date: December 30, 2014
• Est. primary completion date: December 30, 2014
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• patient between 20 and 65 of age with ASA physical status ?-?

• breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies

• surgery performed by the same surgical team

Exclusion Criteria:

• ASA physical status ?

• hepatic and renal impairment

• diabetes or other endocrine disorders

• body mass index > 35 kg/m2

• immune disorders or immunosuppressive therapy

• steroid treatment in the last 6 months

• inflammation

Related Conditions & MeSH terms

• Breast Cancer

Intervention

Procedure:
• intravenous anesthesia
total intravenous anesthesia group: propofol-remifentanil
• inhalation anesthesia
inhalation anesthesia group: sevoflurane-remifentanil

Drug:
• propofol-remifentanil

• sevoflurane-remifentanil

Locations

Country	Name	City	State
Korea, Republic of	Severance Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	number of NK cell	comparison of the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity	at 24 hour after surgery.