Breast Cancer Clinical Trial
Official title:
Delayed Effects of Treatment in Cancer Survivors (DETECS)
Hypotheses and Specific Aims: There is limited data on the long-term consequences of cancer therapy on young, reproductively aged cancer survivors. The investigators objective is to characterize some of these effects in the cancer population.
Specific Aim 1: To compare markers of ovarian reserve between cancer survivors and healthy
controls.
Hypothesis: Cancer survivors will have lower serum Anti-Mullerian Hormone (AMH) and antral
follicle count (AFC), and higher Follicle Stimulating Hormone (FSH) than healthy controls.
Specific Aim 2: To compare cardio-metabolic, endocrine and bone profiles between cancer
survivors and controls using a combination of anthropometric measures, fasting serum
markers, and urinary markers of bone health.
Hypothesis: Cancer survivors will have higher total cholesterol and lower 25-OH vitamin D
than healthy controls.
Specific Aim 3: To evaluate potential associations between ovarian reserve and markers of
metabolism, obesity, and tumor bone health in young female cancer survivors.
Hypothesis: As BMI and total cholesterol increases, serum AMH will decrease.
Specific Aim 4: To compare quality of life markers, as assessed by validated instruments,
between cancer survivors and controls using recommended scoring techniques.
Hypothesis: Cancer survivors will have lower quality of life markers as compared to
controls.
The investigators will conduct a prospective study to characterize the quality of life and
cardio-metabolic, endocrine, and bone profiles of female cancer survivors using a
combination of anthropometric, serum, urinary, and ultrasonographic markers in combination
with QOL instruments.
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