BrUOG 291: Five Fraction Partial Breast Irradiation Using Non-invasive Image-guided Breast Brachytherapy (NIBB)

Breast Cancer Clinical Trial

Official title: BrUOG 291: FIVE FRACTION PARTIAL BREAST IRRADIATION USING NON-INVASIVE IMAGE-GUIDED BREAST BRACHYTHERAPY (NIBB)

Status Completed

Clinical Trial Summary

To evaluate safety of 5 fraction accelerated partial brest irradiation in more convenient 5 fraction schedule.

Clinical Trial Description

The purpose of this study is to evaluate the rate of early and intermediate toxicity related to accelerated partial breast irradiation (APBI) delivered in a more convenient 5 fraction schedule using non-invasive image-guided breast brachytherapy (NIBB) (AccuBoost System) in women with resected, early stage breast cancer.

Non-invasive image-guided breast brachytherapy (NIBB), using advanced image-guided radiation technology, has the potential to eliminate the disadvantages of the conventional APBI techniques. NIBB facilitates non-invasive partial breast irradiation without the use of catheters or implants. Yet by using breast immobilization and precise image-guidance, it reduces non-target breast tissue within the irradiated field compared with other non-invasive APBI techniques such as 3D-CRT. This has made NIBB an attractive approach to deliver APBI.

We hypothesize that NIBB delivered in 5 treatments will be a more convenient, safe and effective modality to deliver partial breast irradiation.

Anticipated advantages of NIBB protocol treatment include:

• Convenient treatment schedule

• Short course can allow for increased patient access to treatment

• Non-invasive approach

• Increased accuracy with precise targeting of lumpectomy cavity using advanced imaging

• Reduced irradiation of non-target breast tissue

• Reduced skin toxicity

• No heart or lung radiation exposure

• Reduced late skin or breast toxicity

• High rate of good or excellent cosmetic outcome

• High rate of ipsilateral breast tumor control comparable to other APBI techniques ;

Related Conditions & MeSH terms

• Breast Cancer

• NCT number: NCT01961531
• Study type: Interventional
• Source: Brown University
• Status: Completed
• Phase: N/A
• Start date: July 24, 2014
• Completion date: November 30, 2021