Breast Cancer Clinical Trial
Official title:
Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer.
The purpose of this project is to examine whether the risk of developing ovarian cancer is
increased in Danish women with congenital missing teeth as a result of their failure to
develop (hypodontia). Should this prove to be the case, these women could be offered regular
clinical controls and prophylactic removal of their ovaries when menopause enters and the
ovaries are no longer functional (producing hormones).
If there is a connection between congenital hypodontia and the development of different
types of cancer, the investigators will perform a genetic screening in families with
increased risk of cancer and hypodontia for changes in relevant genes, based on the current
literature. The investigators hereby search for new genes, which in a changed form leads to
an increased risk of cancer and thereby enables us to perform genetic screening in risk
families.
| Status | Recruiting |
| Enrollment | 200 |
| Est. completion date | August 2015 |
| Est. primary completion date | September 2014 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - confirmed suspicion of ovarian cancer. Exclusion Criteria: - suspicion of ovarian cancer disproved. |
Observational Model: Case Control, Time Perspective: Retrospective
| Country | Name | City | State |
|---|---|---|---|
| Denmark | Copenhagen University Hospital | Copenhagen Ø | Copenhagen |
| Denmark | Aarhus University Hospital | Skejby | Aarhus |
| Lead Sponsor | Collaborator |
|---|---|
| University of Aarhus | Arvid-Nilsson Foundation, Danish Cancer Society |
Denmark,
Chalothorn LA, Beeman CS, Ebersole JL, Kluemper GT, Hicks EP, Kryscio RJ, DeSimone CP, Modesitt SC. Hypodontia as a risk marker for epithelial ovarian cancer: a case-controlled study. J Am Dent Assoc. 2008 Feb;139(2):163-9. — View Citation
Cobourne MT. Familial human hypodontia--is it all in the genes? Br Dent J. 2007 Aug 25;203(4):203-8. Review. — View Citation
Eisinger F, Burke W, Sobol H. Management of women at high genetic risk of ovarian cancer. Lancet. 1999 Nov 6;354(9190):1648. — View Citation
Lammi L, Arte S, Somer M, Jarvinen H, Lahermo P, Thesleff I, Pirinen S, Nieminen P. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet. 2004 May;74(5):1043-50. Epub 2004 Mar 23. — View Citation
Marchini S, Marabese M, Marrazzo E, Mariani P, Cattaneo D, Fossati R, Compagnoni A, Fruscio R, Lissoni AA, Broggini M. DeltaNp63 expression is associated with poor survival in ovarian cancer. Ann Oncol. 2008 Mar;19(3):501-7. Epub 2007 Nov 12. — View Citation
Rølling S, Poulsen S. Oligodontia in Danish schoolchildren. Acta Odontol Scand. 2001 Apr;59(2):111-2. — View Citation
Rølling S. Hypodontia of permanent teeth in Danish schoolchildren. Scand J Dent Res. 1980 Oct;88(5):365-9. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Prevalence rates of hypodontia in women with ovarian cancer | one year | No | |
| Secondary | Genetic causes for hypodontia and ovarian cancer | two years | No | |
| Secondary | Prevalence rates of hypodontia in patients with a known risk for epithelial cancer | one year | No |
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