Breast Cancer Clinical Trial
Official title:
A Pilot Observational Study to Assess Changes in Biochemical Parameters of Ovarian Reserve With Chemotherapy
Premenopausal women who are diagnosed with breast cancer are frequently treated with
chemotherapy. Chemotherapy can affect the ovaries, and the effects can range from temporary
loss of menstrual periods to permanent menopause. It is difficult to predict how an
individual's ovarian function will be affected by chemotherapy. There are a number of
hormones which can be measured in the blood which are related to fertility and ovarian
function. The levels of these hormones may change with chemotherapy, and may relate to the
effect of chemotherapy on the ovaries.
In this study, we plan to enroll 28 women ranging in age from 25 to 50 who are diagnosed
with breast cancer and will be treated with chemotherapy. We will check blood levels of the
hormones before, immediately after, and 1 year after treatment with chemotherapy. We will
only be checking these blood tests for this study; the type of chemotherapy given will be up
to the patient and her oncologist. We will also ask some questions about factors that can
influence the levels of these hormones, such as number of children, age of menopause of
other family members, and smoking history. The results from this study will be used to help
us develop future studies looking at changes in ovarian function with chemotherapy, and the
effects of other breast cancer therapies, such as endocrine therapy, on the ovaries.
n/a
Observational Model: Case Control, Time Perspective: Retrospective
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