Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05569993 |
| Other study ID # |
Traumatic brain injury |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
Early Phase 1
|
| First received |
|
| Last updated |
|
| Start date |
October 30, 2022 |
| Est. completion date |
December 30, 2023 |
Study information
| Verified date |
October 2022 |
| Source |
Assiut University |
| Contact |
Engy Raafat Youssif, Master student |
| Phone |
01226016909 |
| Email |
Engiraafat95[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Glutamate is an important neurotransmitter present in over 90% of all brain synapses and is a
naturally occurring molecule that nerve cells use to send signals to other cells in the
central nervous system.
Glutamate is a non-essential amino acid with restricted passage to the brain from the blood.
In the CNS, glutamate is synthesised in neurons as part of the glutamate-glutamine cycle.5,6
so it plays an essential role in normal brain functioning and can improve situations related
to impaired cognitive,motor and emotional functions and can be used to improve traumatic
brain injury patient general health status
Description:
The term "brain injury" covers a wide range of conditions and injuries relating to the brain,
skull, and scalp. A traumatic brain injury (TBI) usually results when the head or body
suffers from a violent blow or jolt that results in swelling, bruising, bleeding, or tearing
of the brain tissue which any damage to it has the potential to change the way your body
operates.
Now ,(TBI) is considered one of the major causes of disability and deaths ,As It contributes
more than 30% Of deaths worldwide . Those who survive a TBI can face effects that last a few
days, or the rest of their lives. Effects of TBI can include impaired motor, cognitive and
emotional functioning. These issues not only affect individuals but can have lasting effects
on families and communities.TBI can also cause some inflammatory mediators to be released in
circulation that affect brain and systemic organs such as cortisol,IL6 and TNF etc. A lot of
modialities have been introduced to help in decreasing these side effects.
Glutamine,a non-essential amino acid present abundantly throughout the body and is involved
in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the
principal carrier of nitrogen in the body and is an important energy source for many
cells.glutamine has a restricted passage to the brain from blood but it is synthesised in the
brain as a part of the glutamate-glutamine cycle.5,6 so it present in over 90% of all brain
synapses and is a naturally occurring molecule that nerve cells use to send signals to other
cells in the central nervous system,maintaining normal brain function and can improve
situations related to impaired cognitive,motor and emotional functions.
Hypothesis of this study; Does glutamine therapy have a positive effect on traumatic brain
injury patients ?
