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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03318822
Other study ID # STUDY00001960
Secondary ID 2016-9625
Status Completed
Phase
First received
Last updated
Start date August 1, 2017
Est. completion date December 31, 2020

Study information

Verified date May 2021
Source Emory University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of the study is to assess the usability and tolerability of this jugular vein compression device in a population of helmeted and non-helmeted competitive high school, collegiate and professional athletes in the sports of football and rugby. This study differs from previous work in that it is designed to capture additional data related to the athlete experience wearing the jugular vein compression device in older and more elite playing levels.


Description:

Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from blast trauma or concussive events, would save lives, and the huge costs incurred for life-treatment of surviving victims. An externally-worn medical device that applies mild jugular compression according to the principle of the Queckenstedt Maneuver (the Device) is being developed by Q30 Sports Science, LLC (Q30). Preliminary research suggests that the Device has the potential to reduce the likelihood of TBI. The currently developed collar has been approved for studies in humans and the results indicate safety for use during high demand and maximal exertion activities. Regarding safety, the externally worn collar is meticulously designed to mimic the body's own omohyoid muscle actions upon the jugular veins that will provide similar pressure and volume increases not to surpass that of a yawn or the mere act of just lying down. This study will investigate the tolerability of this device in athletes participating in the competitive sports of football and rugby at the high school, collegiate or professional levels.


Recruitment information / eligibility

Status Completed
Enrollment 200
Est. completion date December 31, 2020
Est. primary completion date July 30, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 14 Years to 49 Years
Eligibility Inclusion Criteria: - Normal healthy volunteer - Able to provide written consent - Must be 14 years or older and a participant in collegiate/professional sports of football or rugby Exclusion Criteria: - Unable to provide written consent - History of neurological deficits, previous cerebral infarction, or severe head trauma as indicated through pre-season screening: - Medical contraindications to restriction of venous outflow via the internal jugular veins (known increased intracerebral pressure, metabolic acidosis or alkalosis) - Glaucoma (Narrow Angle or Normal Tension) - Hydrocephalus - Recent penetrating brain trauma (within 6 months) - Known carotid hypersensitivity - Known increased intracranial pressure - Central vein thrombosis - Any known airway obstruction - Any known seizure disorder

Study Design


Intervention

Device:
Q-Collar
An externally-worn medical device that applies mild jugular compression

Locations

Country Name City State
United States Cincinnati Childrens Hospital Medical Center Cincinnati Ohio

Sponsors (2)

Lead Sponsor Collaborator
Emory University Children's Hospital Medical Center, Cincinnati

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Tolerability of collar usage measure subject tolerability to wearing the device via weekly survey 1 year
Secondary Compliance of collar usage measure subject compliance to wearing the device via weekly survey completion 1 year
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