Hypertension Clinical Trial
Official title:
Effects of Angiotensin II Receptor Blockers (ARB) and Angiotensin Converting Enzyme Inhibitors (ACEI) on Progression of Silent Brain Infarction and Cognitive Decline in Japanese Patients With Essential Hypertension in the Elderly
The purpose of this study is to elucidate whether or not angiotensin II receptor blockers (ARB) are more beneficial or equal to angiotensin converting enzyme inhibitors (ACEI) on development or progression of silent brain infarction and cognitive decline in Japanese patients with essential hypertension in the elderly.
Hypertension plays a major role in the development of cardiovascular diseases. Treating
hypertension has been associated with reduction in the risk of stroke and myocardial
infarction. Angiotensin converting enzyme inhibitor (ACEI), ramipril, showed a 32 % in
relative risk of reduction in the Heart Outcomes Prevention Evaluation (HOPE) trial.
Angiotensin II receptor blocker (ARB), losartan, also showed a 25 % in relative risk of
reduction in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE).
Elderly people, especially hypertensive patients, with silent brain infarction have an
increased risk of stroke and cognitive decline. However, no reports are seen on comparison
of the effects of ARBs and ACEIs on progression of silent brain infarction and cognitive
decline in patients with essential hypertension in the elderly.
The researchers therefore longitudinally evaluate silent brain infarction using magnetic
resonance imaging and cognitive decline by Mini-Mental State Examination twice at an
interval of 2 years in patients with essential hypertension in the elderly who are received
antihypertensive therapy by ARB or ACEI.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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