Breast Neoplasms Clinical Trial
Official title:
A Pilot Study of Stereotactic Ablation for Oligometastatic Breast Neoplasia in Combination With the Anti-PD-1 Antibody MK-3475.
This is a prospective, observational pilot study that will describe the safety profile and
biological effects of combining stereotactic ablative body radiosurgery (SABR) treatment
(20Gy/1#) and a PD-1 antibody, MK-3475.
15 patients with oligometastatic breast cancer with at least one lesion considered safe for
SABR radiotherapy, will be treated with SABR for their oligometatastic disease in addition to
6 months of MK-3475 treatment (1 cycle every 3 weeks, a total of 8 cycles).
This investigator driven pilot study will examine the safety and biological effects of
combining MK-3475 (Pembrolizumab) an antibody targeted against the anti-programmed cell death
1 (PD-1) T cell checkpoint, with SABR therapy for oligometastatic disease. We hypothesise
that the safety profile of this combination, will be clinically acceptable and well tolerated
for patients, and that we will observe evidence of systemic immune activation.
n/a
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