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Bone Cancer clinical trials

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NCT ID: NCT04974008 Completed - Bone Cancer Clinical Trials

Osteosarcoma Maintenance Therapy With OST31-164

OST-164-01
Start date: October 21, 2021
Phase: Phase 2
Study type: Interventional

Up to 45 Patients aged 12 to 39 with osteosarcoma (bone cancer) that had recurred in the lungs and has recently been surgically removed will be enrolled. Patients will receive OST31-164 infusions every 3 weeks over 48 weeks and be followed after that for 3 years.

NCT ID: NCT04310410 Completed - Pain Clinical Trials

Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis

PRE-FURTHER
Start date: April 11, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The PRE-FURTHER study aims to evaluate the feasibility of the combined treatment with radiotherapy and focussed ultrasound for pain palliation in patients with painful bone metastases, and to optimize the combined treatment logistics. Six to ten patients will be included according to in- and exclusion criteria.

NCT ID: NCT01553539 Completed - Clinical trials for Recurrent Osteosarcoma

Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery

Start date: October 2009
Phase: Phase 2
Study type: Interventional

This phase II trial studies how well therapeutic angiotensin-(1-7) works as second-line therapy or third-line therapy in treating patients with metastatic sarcoma that cannot be removed by surgery. Therapeutic angiotensin-(1-7) may stop the growth of sarcoma by blocking blood flow to the tumor. Funding Source - FDA Office of Orphan Drug Products (OOPD)

NCT ID: NCT01336803 Completed - Osteosarcoma Clinical Trials

Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI

Osteosarcoma
Start date: August 2011
Phase: Phase 2
Study type: Interventional

This pilot trial studies the differentiation of bone sarcomas and osteomyelitis with ferumoxytol-enhanced magnetic resonance imaging (MRI). Imaging procedures that allow doctors to more accurately differentiate between malignant bone sarcomas and osteomyelitis may help in diagnosing patients correctly and may result in more timely treatment.

NCT ID: NCT01135849 Completed - Breast Cancer Clinical Trials

B-Receptor Signaling in Cardiomyopathy

Start date: November 2008
Phase: N/A
Study type: Observational

We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether certain individuals have increased susceptibility to cardiac injury.

NCT ID: NCT01091883 Completed - Pain Clinical Trials

Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma

Start date: May 2010
Phase: N/A
Study type: Interventional

The goal of this study is to collect comparative data on safety and efficacy of MR Guided Focused Ultrasound and External Beam Radiation for treatment of metastatic bone tumors or multiple myeloma.

NCT ID: NCT01085565 Completed - Pain Clinical Trials

Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System

Start date: March 2010
Phase: Phase 2
Study type: Interventional

The goal of this prospective, non-randomized, single-arm, phase 2 study is to evaluate the safety and effectiveness of this treatment using this ExAblate conformal system in the treatment of pain resulting from metastatic bone tumors Up to Fifty (50) patients will be recruited in this feasibility study. The treated patients will be followed for 3-Months post their last treatment, patients with the standard contraindications to MRI examination, such as implanted metal devices (pacemakers, etc.), will be excluded.

NCT ID: NCT01047878 Completed - Bone Cancer Clinical Trials

Genomic Analysis of Pediatric Bone Tumors

Start date: August 2007
Phase:
Study type: Observational

To determine whether gene expression analysis of primary tumor samples before and after chemotherapy are predictive of long-term survival in pediatric patients with bone sarcomas (Ewings sarcoma (ES) and Osteosarcoma(OS)).

NCT ID: NCT00160758 Completed - Bone Cancer Clinical Trials

Physical Characteristics of Retrieved Massive Allografts

Start date: December 1999
Phase: Phase 4
Study type: Observational

This purpose of this study is to measure the strength of tissue allografts that have been in the body various lengths of time.

NCT ID: NCT00160719 Completed - Bone Cancer Clinical Trials

HLA Sensitization Following Major Cortical Allograft Bone Procedures

Start date: September 1999
Phase: Phase 4
Study type: Observational

The purpose of this study is to find out whether or not antibodies to the donor bone are present in the blood of patients who receive the donor bone.