Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Bone and Joint Infection Clinical Trial

— CRISBO  

Official title:

Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04625478
• Other study ID #: 229
• Status: Completed
• Start date: December 1, 2020
• Est. completion date: December 20, 2021

Study information

• Verified date: January 2022
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI.

The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: December 20, 2021
• Est. primary completion date: September 20, 2021
• Gender: All
• Age group: 18 Years to 95 Years

Eligibility

Inclusion Criteria:

• patients having had an osteo-articular infection with Staphylococci

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Arthritis, Infectious
• Bone and Joint Infection
• Communicable Diseases
• Infections
• Staphylococcus

Intervention

Other:
• Patients having had an osteo-articular infection with Stahylococcus
Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Locations

Country	Name	City	State
France	Hospices Civils de Lyon	Lyon

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	detection of intracellular staphylococci	to explore if intracellular staphylococci can be observed on samples of patient having an osteo-articular infection with staphylococci	2 months
Primary	rate of localisation of intracellular staphylococci	to explore where in what type of celles they can be observed on samples of patient having an osteo-articular infection with staphylococci	2 months

External Links

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