Bone and Joint Infection Clinical Trial
Official title:
Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections
Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI. The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05421312 -
Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip
|
Phase 4 | |
| Active, not recruiting |
NCT04563325 -
Oral-only Antibiotics for Bone and Joint Infections in Children
|
Phase 4 | |
| Completed |
NCT03627000 -
Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
|
||
| Completed |
NCT03311113 -
Adherence to Oral Antibiotics In Patients With Osteoarticular Infections
|
||
| Recruiting |
NCT05753215 -
Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection
|
Phase 2 | |
| Completed |
NCT03209921 -
Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections
|
N/A | |
| Completed |
NCT04418882 -
Septic Management and Outcome of Open Fracture
|
||
| Completed |
NCT05248490 -
Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home
|
N/A | |
| Completed |
NCT03624855 -
Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France
|
||
| Recruiting |
NCT04496024 -
Ofloxacin Concentration-toxicity Relationship in the Elderly
|
N/A | |
| Recruiting |
NCT04933344 -
Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infections
|
||
| Recruiting |
NCT04538053 -
BonE and Joint Infections - Simplifying Treatment in Children Trial
|
Phase 4 | |
| Completed |
NCT04373278 -
Infection After Free Fibula Flap Reconstruction of the Mandible: a Retrospective Cohort Study
|
||
| Completed |
NCT03209934 -
Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center
|
N/A | |
| Recruiting |
NCT02817711 -
Lyon BJI Cohort Study
|
N/A | |
| Recruiting |
NCT03611634 -
Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine
|
||
| Completed |
NCT03177369 -
Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration
|
N/A | |
| Recruiting |
NCT04722926 -
Lyon PJI Retrospective Cohort Study
|
||
| Completed |
NCT03852784 -
Osteoarticular Infections With Pneumococcal
|
||
| Recruiting |
NCT03796104 -
Prognostic Impact of Delta-haemolysin Production Deficiency in Staphylococcus Aureus on the Prognosis of Infected Implant Treated by DAIR
|