Body Weight Clinical Trial
Official title:
CCRC: Understanding the Effects of Omega-3 Fatty Acids vs. Lignans in Flaxseed on Metabolic and Inflammatory Markers Leading to Diabetes and Cardiovascular Disease.
The aim of this study is to compare the effects of flaxseed on atherogenic lipids, plasma
inflammatory markers, and insulin sensitivity.
We hypothesize that flaxseed omega-3 fatty acids will improve the lipid profile (decrease
triglyceride, total and LDL-cholesterol and increase HDL-cholesterol).
Flaxseed is the richest dietary source of lignan secoisolariciresinol diglucoside (SDG).
Lignans are estrogens found in plant sources that behave similar to endogenous estrogens and
have been associated with cardiovascular benefits due to their antioxidant activity.
Therefore, we also hypothesize that flax-lignans will cause a significant decrease in LDL
oxidation and in inflammatory markers such as C-reactive protein (CRP), interleukin-6
(IL-6), IL-1B, serum fatty acid binding protein 4 (FABP-4), and serum amyloid attached to
high density lipoprotein (HDL-SAA).
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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