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Blood Transfusion clinical trials

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NCT ID: NCT02648113 Completed - Clinical trials for Myocardial Infarction

Cost-effectiveness and Cost-utility of Liberal vs Restrictive Red Blood Cell Transfusion Strategies in Patients With Acute Myocardial Infarction and Anaemia.

REALITY
Start date: March 23, 2016
Phase: N/A
Study type: Interventional

Anemia in patients with myocardial infarction (MI) is a relatively frequent issue, resulting in poorer outcome. There is equipoise regarding which transfusion strategy is best, and there is an international consensus on the urgent need for a randomized trial. The investigators hypothesize that a "restrictive" transfusion strategy is at least non-inferior to a "liberal" transfusion strategy on 30-day outcomes of MI patients with anemia. Given the costs and risks of transfusion, a cost-effectiveness and cost-utility analysis becomes key to determining the role of each strategy.

NCT ID: NCT02595385 Recruiting - Blood Transfusion Clinical Trials

Blood Conservation in Adult Cardiac Surgery, What is the Way Forward in Today's Practice?

CONSERVE
Start date: February 2015
Phase: N/A
Study type: Interventional

The aim of this study is to compare retrograde autologous priming (RAP) of the bypass circuit to cell salvage (CS) as part of blood conservation strategies in adult cardiac surgery. It hypothesizes that RAP is at least as effective as cell salvage in terms of blood conservation but at the same time more cost effective.

NCT ID: NCT02513966 Completed - Blood Transfusion Clinical Trials

Decreased Consumption of Blood Components During Cardiac Surgery Procedures: Causes and Effects.

Start date: July 2015
Phase:
Study type: Observational

There is a decrease in the amount of blood components used during cardiac surgery in the last four years. As the hemovigilance team of the investigators' Hospital the investigators want to find out the causes and effects of this decrease.

NCT ID: NCT01930305 Completed - Blood Transfusion Clinical Trials

Effects of Heating Transfusion on Brain Function

Start date: June 2012
Phase: N/A
Study type: Observational

To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.

NCT ID: NCT01529502 Completed - Inflammation Clinical Trials

Pilot Study About the Harmful Effects of Blood Storage on Overweight People and the Role of iNO in This Setting

Start date: March 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether storage time affects how human body responds to autologous blood transfusion. An autologous blood transfusion is when a person donates blood and then receives that same blood back in the transfusion. We also want to find out if in this situation inhaled nitric oxide can help to prevent the potential reduction of vasodilation capacity. Vasodilation capacity is the ability of the blood vessel to widen when needed.

NCT ID: NCT01265680 Completed - Blood Transfusion Clinical Trials

Blood Sparing Strategies: Single Shot High Dose Erythropoietin Two Days Before Heart Surgery

SHOT
Start date: February 2012
Phase: N/A
Study type: Interventional

All patients operated on at the European Hospital Heart surgery Division will be randomized to either single dose 80.000 UI of Human Recombinant Erythropoietin and intravenous iron or control. Primary end point is the amount of transfused blood. Secondary end point is the Hemoglobin level in the patient on postoperative day four. Ancillary analysis regarding safety at 45 days and cost effectiveness are planned as well

NCT ID: NCT01218074 Terminated - Bleeding Clinical Trials

Platelets Antiaggregation Control Enhancement (PACE) Study

PACE
Start date: December 2010
Phase: N/A
Study type: Interventional

Many patients undergo cardiac surgery without proper suspension of antiaggregation drugs. This is blamed to increase dramatically bleeding and use of allogenic blood transfusions. The investigators test the hypothesis that routine use of aggregometry could show antiaggregated patient and lead to normalization of platelet function via administration of Desmopressin thus limiting bleeding and transfusions.

NCT ID: NCT01136590 Completed - Hemorrhage Clinical Trials

Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery

Start date: September 2010
Phase: Phase 4
Study type: Interventional

Current evidence regarding the efficacy and safety of perioperative administration of tranexamic acid for antifibrinolysis does not suffice to support its use in major spinal surgery. OBJECTIVES: To evaluate the effectiveness of tranexamic acid for decreasing transfusion requirements and bleeding in this patient population. To evaluate the safety of this antifibrinolytic agent in the intraoperative and mid-term postoperative period. METHODS: Multicenter, randomized, double-blind, placebo-controlled clinical trial with parallel groups. The main outcome measure is intraoperative and postoperative transfusion requirements; blood loss and safety will also be evaluated. Previous results in other types of surgery suggest that tranexamic acid reduces transfusion requirements and blood loss. Hence, the hypothesis of this study is that tranexamic acid will significantly reduce blood loss in comparison to a placebo in major spine surgery.

NCT ID: NCT01094197 Withdrawn - Wounds and Injuries Clinical Trials

Detailed Evaluation of Microchimerism

Start date: March 2010
Phase: N/A
Study type: Observational

Individuals who experience traumatic injury often require blood transfusion. In some individuals who receive blood after an injury, white blood cells from a person who donated blood may remain in the body for years, a condition known as microchimerism. This study is designed to examine a group of people who are known to have long-term microchimerism and, through analysis of their blood, determine whether there is evidence that the microchimerism involves blood stem cells that can become any type of blood cell (red blood cells, white blood cells, or platelets) and that might be a permanent part of the body.

NCT ID: NCT00950547 Completed - Cardiac Surgery Clinical Trials

ICU Cell Saver to Reduce Blood Transfusions in Cardiac

Start date: August 2009
Phase: N/A
Study type: Interventional

PURPOSE: Autotransfusion devices may be employed in cardiac surgery to decrease allogenic blood requirements. Limitations of previous trials include the use of cell saver systems in selected high risk patients only or the lack of blood transfusion-sparing strategies. The aim of this prospective randomized study is to evaluate the efficacy of cell salvage CardioPAT routinely used in cardiac surgery. METHODS: The investigators will randomize 350 patients in two groups: group 1 receives a CardioPAT cell saver device (175 patients), group 2 doesn't receive any cell saver device. The incidence of allogenic blood transfusion and clinical outcome in both groups are evaluated.