Dietary Nitrate and Healthy Older Adults

Blood Pressure Clinical Trial

Official title:

Influence of Dietary Nitrate Supplementation on Blood Pressure, Walking Economy, Functional Physical Capacity and Cognitive Function in Healthy Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03473678
• Other study ID #: 121964
• Status: Completed
• Phase: N/A
• First received: January 31, 2018
• Last updated: March 14, 2018
• Start date: February 12, 2014
• Est. completion date: January 2018

Study information

• Verified date: March 2018
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days

Description:

A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 2018
• Est. primary completion date: May 28, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 70 Years to 80 Years

Eligibility

Inclusion Criteria:

1. 70 - 80 years of age

2. male or female

Exclusion Criteria:

1. involved in regular structured exercise

2. receiving medication for:

• pulmonary conditions

• cardiovascular conditions

• metabolic conditions

• musculoskeletal conditions

• ulcerative colitis

• renal disease

Related Conditions & MeSH terms

• Blood Pressure
• Brain Metabolism
• Cognitive Change
• Functional Capacity

Intervention

Dietary Supplement:
• Nitrate-rich beetroot juice
concentrated beetroot juice
• Nitrate-depleted beetroot juice
concentrated beetroot juice

Locations

Country	Name	City	State
United Kingdom	Sport and Health Sciences, University of Exeter	Exeter	Devon

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure	Change in blood pressure between interventions	10 days
Secondary	Oxygen cost of exercise	Change in oxygen consumption during exercise	10 days
Secondary	Serial Subtraction test	change in performance of the Serial Subtraction test	10 days
Secondary	Microbiome	change in oral microbiome measured by sequencing bacterial 16S rRNA genes	10 days
Secondary	Brain metabolism	change in brain metabolites measured measured by 1H MRS	10 days
Secondary	6 minute walk test	change in performance of 6 minute walk test	10 days