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Blood Loss clinical trials

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NCT ID: NCT06403163 Recruiting - Anesthesia Clinical Trials

Transfusion Surveillance in Anaesthesia

STAR
Start date: September 1, 2022
Phase:
Study type: Observational [Patient Registry]

the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage. The aim is to allow different modelling and analysis related to emergency transfusion.

NCT ID: NCT06279897 Recruiting - Blood Pressure Clinical Trials

LBNP Tolerance With Skin Warming After Exercise Cold Stress

Start date: January 24, 2022
Phase: N/A
Study type: Interventional

Assess the effect of skin rewarming during lower body negative pressure upon arterial blood pressure and tolerance to simulated blood loss after exercise in the cold.

NCT ID: NCT05550623 Recruiting - Amputation Clinical Trials

Pneumatic Tourniquet Versus no Tourniquet in Transfemoral Amputation

Start date: October 10, 2022
Phase: N/A
Study type: Interventional

Lower extremity amputation patients represent a frail group of patients with extensive comorbidity. The most common indication of amputation is ischemia, infection and concomitant ischemic pain due to underlying chronic disease, especially arteriosclerosis and diabetes. Prolonged general anesthesia and surgery as well as increased blood loss may result in impaired patient safety. Previous studies have shown total blood loss approx. 1000 mL in transfemoral amputations (TFA). Substantial blood loss during surgery increases the risk of anemic complications and death for this already weakened patient group. The aim of this randomized controlled trial is to improve patient safety by exploring the possibility of a more precautious surgical procedure for TFA. Hence, investigating the total blood loss and secondary differences in complications after TFA between patients operated with use of pneumatic tourniquet versus no tourniquet. Total blood loss is calculated via Nadlers approach. From a pilot series, sample size was calculated to 124, allocated 1:1 in two groups of 62 participants, to ensure detection of at least 200 mL difference in total blood loss. The hypothesis is that use of tourniquet will decrease the total blood loss, the amount of blood transfusions, time of surgery and complications related to postoperative anemia without a higher rate of adverse events. The secondary and explorative outcomes are blood transfusions, intraoperative blood loss, length of stay, time of surgery, risk of readmission, risk of re-operation, risk of mortality, complications during admission, quality of life (QoL), prosthesis use and the prosthesis-specific survey Prothesis Evaluation Questionnaire (PEQ). QoL is measured with the validated questionnaire EQ-5D-5L preoperatively, and at 3, 6, and 12 months postoperatively. The possibility to enhance patient safety is highly relevant, and this trial will aid in establishing evidence-based guidelines for TFA surgery.

NCT ID: NCT05507983 Recruiting - Burns Clinical Trials

Tranexamic Acid During Excisional Burn Surgery

TRANEX
Start date: December 1, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to access the efficacy of the drug tranexamic acid in reducing blood loss during burn excision surgery.

NCT ID: NCT05371574 Recruiting - Blood Loss Clinical Trials

Clonidine Versus Tranexamic Acid in Reduction of Blood Loss

Start date: January 3, 2022
Phase: Phase 1
Study type: Interventional

Tranexamic acid is an antifibrinolytics agent that has been widely used in the reduction of blood loss at surgeries. Oral clonidine is an alpha-2 adrenergic agonist that has been used in various surgeries including Caesarean section.

NCT ID: NCT05287334 Recruiting - Blood Loss Clinical Trials

Blood Loss Measurement Using Electrical Impedance Tomography

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The project focuses on the possibility of detecting blood loss using electrical impedance tomography. Based on previous animal experiments, it was found that the bolus of saline significantly affects the signal of chest bioimpedance. It is assumed that blood loss of a similar volume will cause a similar signal change with the opposite trend. The aim of this project is to determine whether there is a significant change in the thoracic electrical impedance tomography signal when blood loss is caused by voluntary blood donation.

NCT ID: NCT04777097 Recruiting - Blood Loss Clinical Trials

Blood Loss and Preeclampsia

Start date: January 1, 2021
Phase:
Study type: Observational

Study of blood loss in preeclamptic patients using mathematical formulae

NCT ID: NCT04760301 Recruiting - Blood Loss Clinical Trials

Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss

Start date: February 16, 2021
Phase: N/A
Study type: Interventional

Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation

NCT ID: NCT04475887 Recruiting - Clinical trials for Liver Transplantation

Treatment of Anemia With Intravenous Iron in Patients Listed for Orthotopic Liver Transplantation

TRAILER
Start date: July 23, 2020
Phase: Phase 4
Study type: Interventional

The aim of this study is to investigate whether therapy with intravenous iron carboxymaltose in patients with iron deficiency anemia (IDA) listed for orthotopic liver transplantation (OLT) increases hemoglobin concentrations and reduces intraoperative transfusion of packed red blood cells (PRBCs). The investigators hypothesize that therapy with intravenous iron will increase hemoglobin concentrations and reduce intraoperative transfusion of PRBCs in patients with IDA listed for OLT.

NCT ID: NCT03853434 Recruiting - Blood Loss Clinical Trials

Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.

Embart
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Although angiographic embolization has been introduced for preoperative management of spine metastases in 1975 and is suggested today by many authors in the management of such pathologies, it needs to be confirmed by RCT. It is a minimally invasive procedure, not free from complications. The recent meta-analyzes, due to the limited number of patients included are not exhaustive about the effectiveness of embolization in the reduction of the intraoperative bleeding, especially in the context of poor / moderate metastasis vascularization. We want to evaluate the efficacy of preoperative angiographic embolization of intermediate / poor vascularized spine metastases in reducing intraoperative blood loss during excision surgery.