Blood Flow Clinical Trial
— GA-17bOfficial title:
The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes
NCT number | NCT06426823 |
Other study ID # | GA-17b |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | November 1, 2023 |
Est. completion date | December 2024 |
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with type 2 diabetes.
Status | Recruiting |
Enrollment | 10 |
Est. completion date | December 2024 |
Est. primary completion date | July 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 80 Years |
Eligibility | Inclusion Criteria: - Type 2 diabetes - BMI 20-35 kg/m^2 - Age 20-80 Exclusion Criteria: - Not MRI-compatible implants - Claustrophobia - Abnormal kidney or liver function - Anemia - Planned weight loss or change in diet - Hypertension - Other conditions that could be expected to affect the primary or secondary outcomes |
Country | Name | City | State |
---|---|---|---|
Denmark | Rigshospitalet | Copenhagen |
Lead Sponsor | Collaborator |
---|---|
University of Copenhagen | Rigshospitalet, Denmark |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Redistribution of splanchnic blood flow in the vessel mesenteric superior artery (functional MRI) | Measued with phase-contrast MRI in ml/min | 80 minutes | |
Secondary | GIP levels | Radioimmuno assay on plasma blood sample (pmol/L) | 80 minutes | |
Secondary | GIP(3-30)NH2 levels | Radioimmuno assay on plasma blood sample (nmol/L) | 80 minutes | |
Secondary | Glucose | Bedside measurement of whole blood sample (mmol/L) | 80 minutes | |
Secondary | C-peptide | Electrochemiluminescence immunoassay of plasma blood sample (pmol/L) | 80 minutes | |
Secondary | Insulin | Electrochemiluminescence immunoassay of plasma blood sample (pmol/L) | 80 minutes | |
Secondary | Glucagon | Radioimmuno assay on plasma blood samples (pmol/L) | 80 minutes | |
Secondary | Blood flow in portal vein | Measued with phase-contrast MRI in ml/min | 80 minutes | |
Secondary | Blood flow in coeliac trunc | Measued with phase-contrast MRI in ml/min | 80 minutes | |
Secondary | Blood flow in hepatic artery | Measued with phase-contrast MRI in ml/min | 80 minutes |
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