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The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes — GA-17b  

Blood Flow Clinical Trial

Official title:
The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes

Clinical Trial Summary

This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with type 2 diabetes.

Clinical Trial Description

Each participant will attend four independent randomised experimental days in the MRI-scanner with intravenous infusion (hormone/placebo) and oral ingestion (glucose/water): An intravenous infusion of saline or GIP(3-30)NH2 starts at time point -20 minutes.The infusions are combined with an oral glucose tolerance test (75 gram of glucose dissolved in 250 ml water ingested orally) at time point 0 minutes on two of the experimental days (with and without GIP(3-30)NH2). MRI measurements are repeatedly performed and blood samples are drawn to be analysed for endocrine responses from the intestines, pancreas, and bones. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06426823
Study type Interventional
Source University of Copenhagen
Contact Lærke S Gasbjerg, MD PhD
Phone 25346894
Email lsg@sund.ku.dk
Status Recruiting
Phase N/A
Start date November 1, 2023
Completion date December 2024
View Details
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