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Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones — BIPO  

Bipolar Disorder Clinical Trial

Official title:
Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones

Clinical Trial Summary

Small exploratory open-label pilot study to assess supplementation of a ketone ester (Juvenescence) combined with a 'ketogenic-mimicking diet' as a potential therapy for persons with bipolar disorder.

Clinical Trial Description

The overarching goal of this open-label, exploratory pilot study is to explore biomechanistic effects of exogenous ketone supplementation combined with a low glycemic diet (in effect, a 'ketogenic-mimicking diet') for patients with bipolar disorder. This represents a less restrictive metabolic intervention compared to a strict ketogenic diet while replicating two foundational elements of the ketogenic diet: low levels of glycemic/insulin signaling and high levels of circulating ketones. In addition to assessments of mood stability and global functioning, functional neuroimaging data will be obtained to better characterize the biomechanistic effects of this intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06335875
Study type Interventional
Source University of Michigan
Contact Rob Vangel, BSc
Phone 734-936-1168
Email rvangel@med.umich.edu
Status Recruiting
Phase N/A
Start date May 2024
Completion date March 2027
View Details
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