Bipolar Disorder Clinical Trial
Official title:
Study of the Genetic and Environmental Factors of Vulnerability in Bipolar Disorders
Bipolar disorder is a complex, multifactorial disorder with the intervention of genetic
vulnerability factors. To help the identification of these genetic factors and to improve
genotype-phenotype correlation, the identification of endophenotype through the exploration
of vulnerability characteristics in unaffected first degree relatives have been recommended.
For this purpose, the investigator include bipolar patients, unaffected first degree
relatives and control subjects to perform genetic association studies and subphenotype
analyses. In this study the investigator will focus on subgroups defined according to the
existence of abnormal circadian rhythm (a major indicator of bipolar vulnerability).
Lithium is the leading treatment of bipolar disorders but prophylactic lithium response is
highly variable and difficult to predict due to lack of biomarkers of response. To explore
lithium response variability and to identify biomarkers of response, the investigator
characterise lithium response using "ALDA" scale to conduct pharmacogenetic studies and
pharmacokinetic studies of lithium extended release, in the subpopulation of patients
treated with lithium. As lithium is a circadian agent, the investigator will also explore
the links between lithium response and circadian phenotypes. Finally, using Li7 magnetic
spectroscopy, the investigator will compare lithium brain distribution in a small sample of
good and partial responders to lithium.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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