Interval Training in Bipolar Disorder

Bipolar Disorder Clinical Trial

— HIIT  

Official title:

Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02498730
• Other study ID #: UFRJ-01
• Status: Completed
• Phase: N/A
• Start date: August 2015
• Est. completion date: July 2017

Study information

• Verified date: July 2022
• Source: Universidade Federal do Rio de Janeiro
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Description:

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: July 2017
• Est. primary completion date: July 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 59 Years

Eligibility

Inclusion Criteria:

• Bipolar Criteria (DSM-IV),
• sedentary lifestyle

Exclusion Criteria:

• 60 and over,
• Cardiovascular Disease,
• Panic disorder,
• Metabolic syndrome Diagnosis

Related Conditions & MeSH terms

• Bipolar Disorder
• Disease

Intervention

Behavioral:
• Interval Training
High Intensity Interval Training at 100% VO2Max
• Continuous Training
Continuous Stimulous at 60% VO2Max
• Control
Only Dependent Variables Measures

Locations

Country	Name	City	State
Brazil	Institute of Psychiatry (IPUB)	Rio de Janeiro

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Federal do Rio de Janeiro

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Symptom Scales (Hamilton and Young)	Variable Measured to reduction of symptoms	0 week, 6 week, 12 week
Secondary	Cortical Changes (EEG) - Loreta	Measured to evaluate changes due to training	0 week, 6 week, 12 week
Secondary	VO2Max	Variable Measured to assess cardiovascular improvement	0 week, 6 week, 12 week
Secondary	Cognitive Function	Executive Function, Time Reaction, Atention, and Memory	0 week, 6 week, 12 week