Bipolar Disorder Clinical Trial
Official title:
Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders (Schizophrenia, Affective Spectrum and Anxiety Disorders) - an Open, Single Center, Longitudinal Study
Learning includes the ability to generalize to new situations and respond to similar, yet
not identical stimuli. In previous work, focused on stimulus generalization in healthy
volunteers, tones that were negatively reinforced induce wider generalization curves than
tones that were positively reinforced, and these in turn induce wider curves than neutral
memory (Schechtman et al, 2010).
The current study aimed to evaluate those patterns in different clinical disorders
(including Schizophrenia, Bipolar disorder, MDD, Anxiety disorders (Panic and GAD) and PTSD,
and healthy subjects that would be used as a control), with consideration whether those
patterns are unique to any specific disorder or state.
The generalization patterns evaluation would conduct twice though enable to compare the
stability of those patterns during the course of the illness (i.e during remission compared
to acute state).
The basic paradigm based on conditioning of a tone (sound) with unpleasant noise, and
extinction of that conditioning afterword. During the 60 minutes of evaluation, the
capability to discriminate between the original tone and similar but not identical tones,
and the tendency to categorize similar tones as identical to the original tone. A neutral
tone without conditioning will be used as reference. The clinical diagnosis will conduct by
a senior psychiatrist, and the state would be evaluated using standard questionnaires
n/a
Observational Model: Case Control, Time Perspective: Prospective
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