Bipolar Disorder Clinical Trial
Official title:
Investigating Metabolic Side Effects of Antipsychotic Medications in Children
The purpose of this study is to learn more about weight gain and related side effects when children are treated with antipsychotic medicine for mood disorders.
This protocol is a six month, randomized, open label trial of risperidone versus aripiprazole
in antipsychotic naive youth (7 - 12 years old) who have been identified by their clinical
treatment provider as needing antipsychotic treatment of a bipolar disorder.
This study proposes to monitor changes in metabolic parameters (body mass index percentile, %
body fat, insulin resistance, and lipid levels) over the course of six months treatment with
aripiprazole or risperidone in youth with a bipolar spectrum disorder. We will also assess
possible mechanisms of second generation antipsychotic induced weight gain by monitoring
physical activity and hunger/appetite changes over the course of treatment.
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