A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder

Bipolar Disorder Clinical Trial

Official title:

Association Between Tobacco Smoking and Bipolar Affective Disorder.Clinico-epidemiological, Cross-sectional, Retrospective Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00741299
• Other study ID #: GKN2007
• Secondary ID: GKN2007
• Status: Completed
• Phase: N/A
• First received: August 25, 2008
• Last updated: July 25, 2012
• Start date: August 2007
• Est. completion date: September 2009

Study information

• Verified date: July 2012
• Source: Tirat Carmel Mental Health Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Israel: Ministry of Health
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)

Description:

An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 2009
• Est. primary completion date: July 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Age 18-65 male or female

• DSM -IV criteria for bipolar I affective disorder

• Ability and willingness to sign informed consent for participation in the study

Exclusion Criteria:

• Unwillingness or inability to participate in the study

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Bipolar Disorder
• Genetic Diseases, X-Linked
• Mood Disorders

Locations

Country	Name	City	State
Israel	Tirat Carmel Mental Health Center	Tirat HaCarmel

Sponsors (1)

Lead Sponsor	Collaborator
Tirat Carmel Mental Health Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status.		One interview session	No