Bipolar Disorder Clinical Trial
Official title:
Memantine and Cognitive Dysfunction in Bipolar Disorder
The purpose of this study is to see whether memantine improves memory function in
participants with bipolar disorder who have minimal symptoms. Secondary analyses will test
the role of memantine in improving residual mood symptoms (depression and mania) in
participants with bipolar disorder.
We hypothesize that in participants with bipolar disorder who have minimal symptoms memantine
will be effective in improving cognitive functions, as measured by the difference in
neuropsychological test scores at the beginning and at the end of the trial.
A large proportion of participants with bipolar disorder experience significant cognitive
dysfunction, even when euthymic, after adequate treatment. The cognitive deficits in
asymptomatic patients with bipolar disorder are very important for the participant's
psychosocial function. In this population, cognitive deficits have been associated with poor
psychosocial functioning, such as inability to hold a job. Memantine is a glutamate
N-methyl-D-aspartate (NMDA) receptor antagonist which has shown efficacy in cognitive
dysfunction due to moderate to severe Alzheimer disease.
Demonstrating the role of memantine in reducing cognitive dysfunction in minimally
symptomatic participants with bipolar disorder promises to provide important clinical
information, which could lead to improvements in well-being and functional status for large
populations of participants with bipolar disorder.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05111548 -
Brain Stimulation and Cognitive Training - Efficacy
|
N/A | |
| Completed |
NCT02855762 -
Targeting the Microbiome to Improve Clinical Outcomes in Bipolar Disorder
|
N/A | |
| Recruiting |
NCT05915013 -
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
|
Phase 1 | |
| Recruiting |
NCT05206747 -
Ottawa Sunglasses at Night for Mania Study
|
N/A | |
| Completed |
NCT02513654 -
Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects
|
Phase 1 | |
| Recruiting |
NCT06313918 -
Exercise Therapy in Mental Disorders-study
|
N/A | |
| Completed |
NCT02304432 -
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine
|
Early Phase 1 | |
| Recruiting |
NCT06197048 -
Effect of Nutritional Counseling on Anthropometry and Biomarkers in Patients Diagnosed With Schizophrenia/Psychosis or Bipolar Affective Disorder
|
N/A | |
| Completed |
NCT03497663 -
VIA Family - Family Based Early Intervention Versus Treatment as Usual
|
N/A | |
| Completed |
NCT04284813 -
Families With Substance Use and Psychosis: A Pilot Study
|
N/A | |
| Completed |
NCT02212041 -
Electronic Cigarettes in Smokers With Mental Illness
|
N/A | |
| Recruiting |
NCT05030272 -
Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
|
N/A | |
| Recruiting |
NCT04298450 -
ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention
|
N/A | |
| Active, not recruiting |
NCT03641300 -
Efficacy of Convulsive Therapies for Bipolar Depression
|
N/A | |
| Not yet recruiting |
NCT04432116 -
Time and Virtual Reality in Schizophrenia and Bipolar Disorder
|
N/A | |
| Terminated |
NCT02893371 -
Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies
|
||
| Terminated |
NCT02909504 -
Gao NARASD Lithium Study
|
Phase 4 | |
| Completed |
NCT02970721 -
Use of Psychotropic Medications Among Pregnant Women With Bipolar Disorder
|
||
| Recruiting |
NCT02481245 -
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
|
Phase 2 | |
| Recruiting |
NCT03088657 -
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
|