White Matter in Pediatric Bipolar Disorder: A DTI Study

Status Completed

Clinical Trial Summary

Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.

Clinical Trial Description

We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Bipolar Disorder

Clinical Trial Details

NCT number	NCT00391235
Study type	Observational
Source	Cambridge Health Alliance
Contact
Status	Completed
Phase	N/A
Start date	September 2005
Completion date	October 2008

View Details

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