Riluzole in the Treatment of Bipolar Depression

Status Completed

Clinical Trial Summary

Bipolar disorder is a common and often chronic and debilitating mental illness. The depressive phase of bipolar disorder contributes the largest portion of the disorder, and treatment resistant bipolar depression represents a significant public health problem. Recent research has suggested that bipolar depression is associated with elevated brain glutamate activity. We hypothesize that riluzole, a drug approved for ALS which inhibits glutamate activity, will lead to clinical improvement in patients with bipolar depression.

Clinical Trial Description

We hypothesize that riluzole will lead to significant reduction in depressive symptoms as measured by the Hamilton Depression Rating Scale (HAM-D). Additionally, improvement in depressive symptoms will be associated with reduced glutamate levels in the anterior cingulate cortex, but not parieto-occipital cortex, both at day two and day 42. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00544544
Study type	Interventional
Source	Mclean Hospital
Contact
Status	Completed
Phase	N/A
Start date	June 2007
Completion date	July 2009

View Details

See also
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