Working Memory in Overweight Children With & Without Loss of Control

Status Completed

Clinical Trial Summary

Loss of control (LOC) eating in children is associated with multiple physical and mental health impairments, including obesity and eating disorders. Little is known about the developmental neurobiology of LOC, which is crucial to specifying its pathophysiology and the development of effective preventive interventions. Individual differences in working memory (WM) appear to be related to LOC eating and excess weight status in youth, but the specificity and neural correlates of these individual differences are unclear. Failure to adequately understand the nature of associations between WM and eating behavior in children with overweight/obesity limits the development of appropriately-targeted, neuro-developmentally informed interventions addressing problematic eating and related weight gain in youth. To close this clinical research gap, the current study proposes to investigate the context-dependence of WM impairment and its neural correlates in children with concomitant overweight/ obesity and LOC eating as compared to their overweight/obese peers. Specific aims are to investigate: 1)WM performance in youth with LOC eating relative to overweight/obese controls during recalls in the context of food-related versus neutral distractors; and 2) neural activation patterns during WM performance across both food-related and neutral stimuli. We hypothesize that, relative to their overweight/obese peers, youth with LOC eating will show 1) more errors and slower response times during recalls involving food-related vs. neutral distractors, and fewer errors and faster response times during recalls involving food-related vs. neutral targets; 2) increased activation in prefrontal regions during WM performance across stimuli types relative to overweight/obese controls, and 3) even greater activation in the context of food-related versus neutral distractors. The proposed study is the first to use state-of-the-science neuroimaging methodology to clarify the relations between WM and LOC eating, with strong potential to advance understanding of the associations among executive functioning, excess weight status, and eating pathology, and inform the development of interventions (e.g., WM training) to alleviate their cumulative personal and societal burden.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04117542
Study type	Observational
Source	The Miriam Hospital
Contact
Status	Completed
Phase
Start date	October 18, 2018
Completion date	December 31, 2020

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT03994419` - PErioperAtive CHildhood ObesitY
Recruiting	`NCT06111040` - Nurturing Needs Study: Parenting Food Motivated Children	N/A
Completed	`NCT03036696` - The BEACH Interview Study- Pregnant and Breastfeeding Mothers
Completed	`NCT02959034` - Pediatric Metabolism and Microbiome Repository
Not yet recruiting	`NCT02484612` - Exercise Intensity and Appetite in Adolescents	N/A
Completed	`NCT02545764` - Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children	N/A
Recruiting	`NCT02426346` - A Scalable Weight Control Intervention for Adolescents	Phase 2
Completed	`NCT02160847` - Development of the DRIVE Curriculum to Address Childhood Obesity Risk Factors	N/A
Completed	`NCT01989065` - Healthy Lifestyles Program for You (HLP4U): Augmenting Childhood Obesity Treatment.	N/A
Completed	`NCT01908153` - Taste Reward Processing in Pediatric Obesity
Completed	`NCT02343588` - A National School-based Health Lifestyles Interventions Among Chinese Children and Adolescents Against Obesity	N/A
Completed	`NCT02375490` - Healthy Start to Increase Physical Activity and Improve Healthy Eating in Early Childcare Centres	N/A
Completed	`NCT02074332` - Study on Obesity Intervention With Physical Exercise Among Students in Changping District, Beijing	N/A
Completed	`NCT02086851` - Study of a Structured Parent Intervention on Adolescent Weight Loss Modification Program.	N/A
Terminated	`NCT00846521` - Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity	Phase 4
Completed	`NCT01146314` - A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children	N/A
Completed	`NCT04164277` - FirstStep2Health Intervention	N/A
Withdrawn	`NCT04600648` - Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children	N/A
Completed	`NCT04395430` - A Novel School-clinic-community Online Model of Child Obesity Treatment in Singapore During COVID-19	N/A
Completed	`NCT03139877` - Pediatric Obesity Observational Prospective Trial

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Working Memory in Overweight Children With and Without Loss of Control Eating

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms