Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

Status Completed

Clinical Trial Summary

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Clinical Trial Description

Subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. The investigators will also collect a blood sample at that time. There will be no other visits for the subject. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03419273
Study type	Observational
Source	University of Missouri-Columbia
Contact
Status	Completed
Phase
Start date	July 1, 2017
Completion date	July 1, 2019

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05650307` - CV Imaging of Metabolic Interventions
Not yet recruiting	`NCT05536466` - The Influence of Having Bariatric Surgery on the Pharmacokinetics, Safety and Efficacy of the Novel Non-nucleoside Reverse Transcriptase Inhibitor Doravirine	N/A
Active, not recruiting	`NCT04583683` - Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities	N/A
Completed	`NCT04099654` - The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery	N/A
Completed	`NCT03809182` - Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.	Phase 4
Completed	`NCT03638843` - Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy - Part 2	N/A
Withdrawn	`NCT05845359` - Intraoperative Methadone for Postoperative Pain Control	Phase 4
Not yet recruiting	`NCT04343040` - Perioperative Evaluation of Glucose Profile Using Continuous Glucose Monitoring System in Glucose Intolerant Patients	N/A
Withdrawn	`NCT03095404` - Intravenous Lidocaine for Post-Operative Pain Control in Patients Undergoing Bariatric Bowel Surgery	Early Phase 1
Recruiting	`NCT03100292` - Korean OBEsity Surgical Treatment Study	N/A
Active, not recruiting	`NCT04357119` - Common Limb Length in One-anastomosis Gastric Bypass	N/A
Completed	`NCT04883268` - Focusing on Body Functionality After Bariatric Surgery	N/A
Completed	`NCT03210207` - Gastric Plication in Mexican Patients	N/A
Completed	`NCT02300168` - Neuromuscular Blockade: Outcome and Recovery for Laparoscopic Bariatric Surgery	N/A
Unknown status	`NCT01264120` - The Impact of a Bariatric Rehabilitation Service on Patient Outcomes	N/A
Recruiting	`NCT03972319` - Omega-3 Supplementation for LIver VolumE Reduction Study (OLIVER) Study	Early Phase 1
Terminated	`NCT04626232` - Comparison of the Sleeve Gastrectomy Technique With a Nissen Fundoplication Added to the Conventional Sleeve Gastrectomy Technique in Morbidly Obese Patients	N/A
Completed	`NCT03643783` - Impact of Plasma Soluble Prorenin Receptor in Obese and Type 2 Diabetic Patients
Completed	`NCT04219852` - Contraception and Bariatric Surgery: Evaluation of Contraception and Contraceptive Knowledge of Women Undergoing Bariatric Surgery at the University Hospital of Reims
Recruiting	`NCT05570474` - Effect of Protein Supplementation on Fat Free Mass Preservation After Bariatric Surgery	N/A