Meningitis With Cerebral Vasculitis in Children

Bacterial Meningitis Clinical Trial

Official title:

Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03595761
• Other study ID #: RECHMPL17_0193
• Status: Completed
• Start date: June 1, 2017
• Est. completion date: August 31, 2017

Study information

• Verified date: July 2017
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.

The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).

The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.

Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.

The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae

Description:

Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.

It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: August 31, 2017
• Est. primary completion date: August 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• bacterial meningitis with LCR confirmation

Exclusion criteria:

• tuberculous meningitis, immunosuppressor treatment, material like DVP

Related Conditions & MeSH terms

• Bacterial Meningitis
• Meningitis
• Meningitis, Bacterial
• Vasculitis
• Vasculitis, Central Nervous System

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Found a difference demographic data	Found a difference demographic data between population A and B (age)	1 day
Primary	Found a difference demographic data	Found a difference demographic data between population A and B (gender)	1 day
Primary	Found a difference Clinical manifestation	Found a difference Clinical manifestation between population A and B	1 day
Primary	Found a difference Inflammatory parkers	Found a difference Inflammatory parkers between population A and B	1 day
Primary	Found a difference Infectious agent	Found a difference Infectious agent between population A and B	1 day
Secondary	Found a difference in the evolution of the diseases between group A and B	The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.	1 day
Secondary	In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae.	Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.	1 day