Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03595761
Other study ID # RECHMPL17_0193
Secondary ID
Status Completed
Phase
First received
Last updated
Start date June 1, 2017
Est. completion date August 31, 2017

Study information

Verified date July 2017
Source University Hospital, Montpellier
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.

The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).

The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.

Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.

The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae


Description:

Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.

It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.


Recruitment information / eligibility

Status Completed
Enrollment 17
Est. completion date August 31, 2017
Est. primary completion date August 1, 2017
Accepts healthy volunteers No
Gender All
Age group N/A to 18 Years
Eligibility Inclusion Criteria:

- bacterial meningitis with LCR confirmation

Exclusion criteria:

- tuberculous meningitis, immunosuppressor treatment, material like DVP

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Uhmontpellier Montpellier

Sponsors (1)

Lead Sponsor Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Found a difference demographic data Found a difference demographic data between population A and B (age) 1 day
Primary Found a difference demographic data Found a difference demographic data between population A and B (gender) 1 day
Primary Found a difference Clinical manifestation Found a difference Clinical manifestation between population A and B 1 day
Primary Found a difference Inflammatory parkers Found a difference Inflammatory parkers between population A and B 1 day
Primary Found a difference Infectious agent Found a difference Infectious agent between population A and B 1 day
Secondary Found a difference in the evolution of the diseases between group A and B The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging. 1 day
Secondary In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae. Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging. 1 day
See also
  Status Clinical Trial Phase
Completed NCT01589289 - Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Phase 3
Completed NCT02274285 - DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants Phase 3
Recruiting NCT04771884 - Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
Completed NCT01431326 - Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Not yet recruiting NCT02467309 - Vitamin d Levels in Children With Bacterial Meningitis N/A
Completed NCT01547715 - Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Phase 3
Terminated NCT00774631 - IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Phase 4
Completed NCT00619203 - Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Phase 3
Recruiting NCT05146570 - Early Diagnosis of Native and Device-associated Meningitis N/A
Recruiting NCT03418441 - Central Nervous System Infections in Denmark
Completed NCT01540838 - Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Phase 4
Recruiting NCT03499652 - Neonatal Bacterial Meningitis Cohort
Completed NCT01410474 - Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Phase 3
Completed NCT03226379 - Driving Reduced AIDS-associated Meningo-encephalitis Mortality N/A
Completed NCT03891758 - Confirmatory Study of BK1310 in Healthy Infants Phase 3