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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04777747
Other study ID # lactate for infection
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2021
Est. completion date March 31, 2023

Study information

Verified date October 2022
Source Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.


Description:

Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.


Recruitment information / eligibility

Status Completed
Enrollment 400
Est. completion date March 31, 2023
Est. primary completion date March 31, 2023
Accepts healthy volunteers No
Gender All
Age group 1 Minute to 18 Years
Eligibility Inclusion Criteria: - child's age is from 0 to 18 years - a child is at least diagnosed with viral infection Exclusion Criteria: one of the following conditions appeared: - congenital heart disease or other abnormalities - respiratory failure - hereditary and/or metabolic disease

Study Design


Intervention

Other:
viral infection
a child is infected by virus only
viral and bacterial infection
a child is infected by virus and progress to bacterial infection

Locations

Country Name City State
China Chen Chongqing Chongqing

Sponsors (2)

Lead Sponsor Collaborator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Children's Hospital of Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary level of lactate level of lactate in both viral and viral and bacterial infection groups three days after admission
Primary the level of lactate dehydrogenase(LDH) level of LDH in both viral and viral and bacterial infection groups three days after admission
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