Bacterial Infections Clinical Trial
— CRPvOfficial title:
CRP Velocity as a Marker for Bacterial Infections in Children
Verified date | July 2010 |
Source | Shaare Zedek Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | Israel: Ethics Commission |
Study type | Observational |
Fever is one of the most common problems in pediatrics. Differentiating between bacterial
infections, that require antibiotic therapy, and viral infections that resolve on their own
is an important challenge for physicians.
C-reactive protein (CRP) is a protein that increases in response to inflammation and its
level is generally higher in bacterial infections compared to viral infections. it can be
measured by a simple blood test, however its utility as a sole marker for bacterial
infection is limited.
The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by
the hours since the fever started will improve the utility of CRP for the diagnosis of
bacterial infections in children.
Status | Not yet recruiting |
Enrollment | 200 |
Est. completion date | September 2011 |
Est. primary completion date | September 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 5 Years |
Eligibility |
Inclusion Criteria: - children less than 5 years of age, - children with no comorbidities and fever > 38 for at least 24 hours, and - children with no previous antibiotic therapy. Exclusion Criteria: - HIV, - immunosuppressive conditions, - antibiotic therapy. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Shaare Zedek Medical Center |
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