Procalcitonin Level and Kinetics in Children With Bacterial Infections

Bacterial Infections Clinical Trial

Official title:

Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00714402
• Other study ID #: pct.ctil
• Status: Completed
• Phase: N/A
• First received: July 9, 2008
• Last updated: May 17, 2011
• Start date: August 2008

Study information

• Verified date: January 2009
• Source: Shaare Zedek Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Israel: Helsinki committee
• Study type: Observational

Clinical Trial Summary

The purposes of this study are:

1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length

2. To examine the kinetics of procalcitonin in pediatric patients with bacterial infections and persistent fever

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 16 Years

Eligibility

Inclusion Criteria:

• Positive blood, urine, synovial, bone, pleural effusion, abscess or CSF culture

• Cellulitis, lobar pneumonia, osteomyelitis,

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Arthritis, Infectious
• Bacteremia
• Bacterial Infections
• Cellulitis
• Communicable Diseases
• Infection
• Lobar Pneumonia
• Mastoiditis
• Meningitis
• Osteomyelitis
• Septic Arthritis
• Urinary Tract Infection
• Urinary Tract Infections

Locations

Country	Name	City	State
Israel	Shaare Zedek Medical Center	Jerusalem	Pob 3235

Sponsors (1)

Lead Sponsor	Collaborator
Shaare Zedek Medical Center

Country where clinical trial is conducted

Israel, 

References & Publications (8)

Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993 Feb 27;341(8844):515-8. — View Citation

Boussekey N, Leroy O, Alfandari S, Devos P, Georges H, Guery B. Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia. Intensive Care Med. 2006 Mar;32(3):469-72. Epub 2006 Feb 14. — View Citation

Christ-Crain M, Stolz D, Bingisser R, Müller C, Miedinger D, Huber PR, Zimmerli W, Harbarth S, Tamm M, Müller B. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med. 2006 Jul 1;174(1):84-93. Epub 2006 Apr 7. — View Citation

Hatherill M, Tibby SM, Turner C, Ratnavel N, Murdoch IA. Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock. Crit Care Med. 2000 Jul;28(7):2591-4. — View Citation

Le Moullec JM, Jullienne A, Chenais J, Lasmoles F, Guliana JM, Milhaud G, Moukhtar MS. The complete sequence of human preprocalcitonin. FEBS Lett. 1984 Feb 13;167(1):93-7. — View Citation

Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J. Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med. 2008 Mar 1;177(5):498-505. Epub 2007 Dec 20. — View Citation

Schuetz P, Christ-Crain M, Wolbers M, Schild U, Thomann R, Falconnier C, Widmer I, Neidert S, Blum CA, Schönenberger R, Henzen C, Bregenzer T, Hoess C, Krause M, Bucher HC, Zimmerli W, Müller B; ProHOSP study group. Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial. BMC Health Serv Res. 2007 Jul 5;7:102. — View Citation

Seligman R, Meisner M, Lisboa TC, Hertz FT, Filippin TB, Fachel JM, Teixeira PJ. Decreases in procalcitonin and C-reactive protein are strong predictors of survival in ventilator-associated pneumonia. Crit Care. 2006;10(5):R125. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	time to defervescence		discharge	No
Secondary	length of hospitalization		discharge	No