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Bacterial Colonization clinical trials

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NCT ID: NCT05893810 Recruiting - Quality of Life Clinical Trials

Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis

Start date: July 1, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether bacterial decolonization of the nares prior to treatment with radiotherapy (RT) for patients with nasopharyngeal carcinoma, can prevent high-grade radiation-induced oral mucositis (RIOM) and improve quality of life. This study is being conducted because a randomized clinical trials form Yana Kost et al. have found bacterial decolonization in the nose prior to initiation of RT was effective for prevention of acute radiation dermatitis. Patients in the treatment arm will receive pretreatment with mupirocin ointment to the nares while patients in the control arm will receive standard of care treatment. Bacterial cultures will be taken from the nares and mouth, and participants will also complete a quality of life questionnaire before and after RT.

NCT ID: NCT02307383 Recruiting - Clinical trials for Bacterial Colonization

Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers

Start date: October 2014
Phase: Phase 2
Study type: Interventional

The combination of Lactitol and Probiotics (Lactobacillus acidophilus and Lactobacillus Biphidus) administered orally is an effective strategy of intestinal decolonization of Enterobacter produced OXA-48-type carbapenemase. The purpose of this study is to determine the effectiveness of Lactitol and Probiotics for the intestinal decolonization of people who carried Klebsiella pneumoniae produced OXA-48-type Carbapenemase.

NCT ID: NCT02017145 Unknown status - Clinical trials for Surgical Site Infection

Study on the Reapplication of Chloraprep After Lower Extremity Surgery and Prior to Dressing Application

Start date: February 2014
Phase: Phase 4
Study type: Interventional

The purpose of the current work is to determine the efficacy of the re-application of surgical prep solution in decreasing surgical site bacterial contamination following lower extremity surgery. Decreasing the extent of bacterial colonization of the skin surrounding the surgical site during the initial healing phases would theoretically decrease the rate of infection in high-risk persons.

NCT ID: NCT01016925 Completed - Clinical trials for Bacterial Colonization

Bacterial Colonization After Tunneling in Femoral Perineural Catheters

Tunnelized KT
Start date: December 2009
Phase: N/A
Study type: Interventional

Background: Bacterial colonization of peripheral nerve catheters is frequent, although infection is relatively rare. With central venous catheters, the tunneling of catheter into the subcutaneous tissue significantly decreases catheter colonization and catheter-related sepsis. Purpose: The aim of this study is to evaluate the incidence of bacterial colonization in adult patients with femoral tunnelized perineural nerve catheters. Methods: A total of 338 patients with femoral catheter will be included in the study. The patients will be randomized to be included in the control group (without tunnelling) or in the group with catheter tunneled 2-3 cm subcutaneously. After removal, catheter will be analyzed for colonization (primary outcome). Quantitative culture will be used as described by Brun-Buisson for intravascular catheters. The site of insertion will be monitored daily for any signs of infection (secondary outcome). Perspective: To show the incidence of femoral perineural catheter colonization is low with subcutaneous tunneling

NCT ID: NCT00946049 Completed - Clinical trials for Bacterial Colonization

Oral Bacteria on Suture Materials - Clinical Comparison of an Antibacterial-coated and a Non-coated Suture Material

Start date: March 2005
Phase: N/A
Study type: Interventional

Antibacterial Triclosan-coated suture material (VICRYL PLUS®, Ethicon) and non-coated (VICRYL®) was compared for bacterial colonization after third molar extraction. Sutures were removed postoperatively and adhered bacteria were investigated.

NCT ID: NCT00336427 Completed - Pregnancy Clinical Trials

MRSA Colonization in Peripartum Women and Their Offspring

Start date: September 2005
Phase: N/A
Study type: Observational

We hypothesize that pregnant women are at baseline risk for carrying community-acquired MRSA, but also have frequent contact with healthcare workers which may put them at risk for hospital-acquired MRSA carriage. Our study aimed to identify the colonization rate of women in active labor and whether transmission to infants may occur.