Emotional and Change-related Attention in Autism

Autism Spectrum Disorders Clinical Trial

— AUTATTEN  

Official title:

Emotional and Change-related Attention in Autism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02160119
• Other study ID #: C13-26
• Secondary ID: 2013-A01315-40
• Status: Completed
• Start date: May 27, 2014
• Est. completion date: May 27, 2018

Study information

• Verified date: August 2021
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and auditory modalities in subjects with ASD compared to healthy controls and also, over the course of development (children, adults). In order to achieve this goal, the investigators will use complementary techniques (EEG and MRI-based techniques (fMRI, DTI)).

Description:

Autism Spectrum Disorders (ASD) are characterized by major handicap in social interaction and in daily life adaptation. The orienting response towards potentially relevant events involves automatic attentional mechanisms that would be elicited mainly by two classes of biologically important stimulations: novel stimuli and emotional stimuli. The neural basis of emotional and change-related attention in ASD will be explored by investigating brain reactivity in both visual and auditory modalities, during tasks mixing emotional and non emotional stimuli.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: May 27, 2018
• Est. primary completion date: May 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years to 45 Years

Eligibility

Inclusion Criteria:

• No past history of central nervous system disorders
• Written consent
• Affiliated to the National Health Insurance
• Do not participate to another biomedical research
• For ASD group: Children with autism spectrum disorder (DSM-V criteria) and adults with high-functioning autism
• For healthy subjects: No past history of difficulties in early childhood for acquisition of walk, language or reading and no psychiatric disorders

Exclusion Criteria:

• Abnormal corrected vision
• Abnormal audition
• Not stabilized psychoactive treatment or treatment that can modify electrogenesis
• Infectious or metabolic diseases
• Epilepsies
• Impossibility to participate to the whole study
• For subjects participating to the MRI recordings: MRI counter-indications (pace-makers ...), claustrophobia or a positive pregnancy test

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Autism Spectrum Disorders
• Autistic Disorder

Intervention

Other:
• MRI-based techniques
fMRI, DTI
• EEG
ERP

Locations

Country	Name	City	State
France	University Hospital	Tours

Sponsors (1)

Lead Sponsor	Collaborator
Institut National de la Santé Et de la Recherche Médicale, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neural responses to neutral and emotional stimuli	ERP (Event-related potential), fMRI and DTI	1 day