Near Infrared Spectroscopy in Children With Autism & ADHD

Status Terminated

Clinical Trial Summary

Background:

- Near-infrared spectroscopy (NIRS) is a functional imaging technique that can be uses light to study brain function while allowing for movement. To look at blood flow in the brain, NIRS uses a low-power light source with detectors that see how the light changes as it passes through brain tissue. Brain blood flow can indicate which parts of the brain are active during different tasks. Researchers want to study children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) and will use NIRS to compare the blood flow in the brain of children with ADHD and ASD with that of typically developing children.

Objectives:

- To see how well NIRS can detect changes in brain blood flow during tests of thinking and memory in children.

- To compare blood flow in the brains of typically developing children and those with ADHD or ASD.

Eligibility:

- Children between 4 and 8 years of age with ASD, ADHD, or children with no psychiatric diagnoses.

Design:

- Participants will be screened for eligibility. Those who are taking stimulant medication for ADHD or ASD will need to stop taking it for 3 days before the study visit.

- After participating in a screening assessment, all participants will have one study visit. At this visit, they will have be asked to complete two tasks during a NIRS scan. For both tasks, they will react to images on a computer screen. This visit will last about 2 hours.

- This is a testing study only. No blood or other samples will be needed for this study.

Clinical Trial Description

Objective: to test whether Near Infra-Red Spectroscopy (NIRS) can be used to monitor cognitive brain function and detect markers for differentiation of Autism Spectrum Disorders (ASD) and Attention Deficit Hyperactivity Disorder (ADHD).

Study population: Children with ASD, ADHD, and typically developing children, all between 4 and 8 years of age.

Design: The study will investigate NIRS signal changes while children with ASD, ADHD, and typically developing children perform well-known functional tasks.

Outcome Measures: Graded changes in blood flow and oxygen, measured with NIRS, in response to different functional tasks. ;

Study Design

Related Conditions & MeSH terms

Attention Deficit Disorder
Attention Deficit Disorder With Hyperactivity
Attention Deficit Hyperactivity Disorder
Autism
Autism Spectrum Disorder
Autism Spectrum Disorders
Autistic Disorder
Disease
Hyperkinesis

Clinical Trial Details

NCT number	NCT01730079
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact
Status	Terminated
Phase
Start date	October 23, 2012
Completion date	April 11, 2017

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Near Infrared Spectroscopy in Children With Autism and ADHD

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms