Autism Spectrum Disorders Clinical Trial
Official title:
The Development of Younger Siblings of Children With Autism Now at 10 Years of Age
Background: Autism is a complex developmental disorder involving difficulties in verbal and
nonverbal communication, social-emotional functioning, and markedly restricted interests and
activities. Strong evidence from research conducted with family members of children with
autism supports the role of genetic factors in its etiology. Thus, some family members are
characterized by the broad autism phenotype (BAP) which involves a clinical picture of
milder but qualitatively similar difficulties.
Working hypothesis and aims: Researchers recently initiated prospective longitudinal studies
investigating the early developmental profiles of young siblings of children with autism
(SIBS-A). Such longitudinal SIBS-A study is currently conducted at the Hebrew University and
includes the oldest siblings studied to date. Our main aim is to identify siblings who
manifest any autism or BAP characteristics.
Methods: Two groups, SIBS-A (n = 42) and siblings of children with typical development
(SIBS-TD, n = 62), were seen at ages 4, 14, 24, 36, 54 months and 7 years. We plan to
continue the investigation at age 10 years, a time when school related abilities and
social/emotional competences are more consolidated and to investigate the developmental
trajectories of children's abilities from age 4 months to 10 years using growth curve
analyses.
Expected results: We expect that compared to SIBS-TD, significantly more 10-year-old SIBS-A
will display difficulties related to ASD or BAP related difficulties. We also expect to
identify different patterns of stability and/or change in the development of children's
abilities from age 4 months to 10 years, between the two groups.
Importance: This study provides a useful approach for the examination of the main research
hypothesis regarding the development of SIBS-A. One of the main advantages of using the
growth curve analysis is the identification of early predictive markers for future
development.
Probable implications to Medicine: This research has significant implication for early
identification and the search into the causes of autism and the BAP, as well as for
implementation of early treatment and prevention programs. By highlighting expressions of
ASD and the BAP in siblings, we may identify early clinically predictive behavioral markers
associated with their onset and contribute to the investigation of underlying genetics
mechanisms.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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