Autism Spectrum Disorder Clinical Trial
Official title:
Psychopathological Differences Between Asperger Syndrome/Normal IQ, no Language Impairment Autism Spectrum Disorder and Schizotypal Disorder in an Adult Sample
NCT number | NCT02800681 |
Other study ID # | E-61120-06 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | June 2016 |
Est. completion date | December 2018 |
Verified date | March 2020 |
Source | Mental Health Services in the Capital Region, Denmark |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to identify psychopathology (psychiatric symptoms) that can
differentiate between Schizotypal Disorder (SD) and Asperger Syndrome (normal IQ, no language
impairment Autism Spectrum Disorder) (AS) in young adults.
With our present knowledge, the differentiation between AS and SD can be difficult, as they
both present with social difficulties, odd (but not psychotic) behaviour, and a 'feeling of
not being as everyone else'. Studies suggest that adults with AS symptoms are either
overlooked, or diagnosed within the schizophrenia spectrum in Adult Psychiatry.
A 'correct' diagnosis is important, as it is the first step towards the most optimal plan,
treatment and rehabilitation for the patient. The only way to diagnose psychiatric illness is
the description of present psychopathology.
To identify symptoms that can differentiate between the two disorders, we will use
semi-structured interviews to explore present psychopathology in young adults with typical
symptoms of SD and AS respectively, with special focus on presence of alterations in
self-experience. Alterations in self-experience are typical for the schizophrenia spectrum,
and are therefore not thought to be equally present in AS and SD.
The hypotheses are that the total level of altered experiences is higher in SD, than in AS,
and with a different pattern of altered experiences in SD than in AS. If the hypotheses are
true, an examination of altered self-experience will be valuable to aid clinical
differentiation between the two disorders.
Status | Completed |
Enrollment | 59 |
Est. completion date | December 2018 |
Est. primary completion date | December 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - ICD-10 diagnosis of Asperger syndrome (F84.5) or infantile autism (F84.0) with normal IQ and no language impairments or schizotypal disorder (F21) - Age 18-30 (both inclusive) Exclusion Criteria: - Known non-verbal IQ < 80 (verbal IQ < 70) or an educational level corresponding to <9 years of primary education - Diagnosed with both Schizophrenia Spectrum Disorder and Autism Spectrum Disorder - Psychotic symptoms (< 1 day of duration, lifetime) - Severe physical illness (life-limiting, or limiting interview capacity) - Organic brain disorder (corresponding to ICD-10 chapter F00-09) - Active heavy alcohol or substance abuse (corresponding to ICD-10 definitions) - Not fluent in the Danish language - Forensic patients |
Country | Name | City | State |
---|---|---|---|
Denmark | Mental Health Centre Ballerup, Mental Health Services, The Capitol Region, Copenhagen | Ballerup | Copenhagen |
Denmark | The Danish Autism Centre | Herlev |
Lead Sponsor | Collaborator |
---|---|
Mental Health Services in the Capital Region, Denmark | The Danish Autism Centre |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Global severity of symptoms assessment | Score, Clinician Global Impressions Scale (CGI) | Assessed within 1,5 years from study inclusion start | |
Other | Global functioning assessment | Score, Global Assessment of Functioning (GAF) | Assessed within 1,5 years from study inclusion start | |
Primary | Level of altered experiences | Total score, Examination of Anomalous Self Experience (EASE) | Assessed within 1,5 years from study inclusion start | |
Primary | Pattern of most occurring altered experiences | Pattern of individual items, Examination of Anomalous Self Experience (EASE) | Assessed within 1,5 years from study inclusion start | |
Secondary | Autism Spectrum symptom load | Total score, Autism Diagnostic Observation Schedule (ADOS), module 4 | Assessed within 1,5 years from study inclusion start | |
Secondary | Schizophrenia Spectrum symptom load | Score, Schedules for Assessment in Neuropsychiatry (SCAN) | Assessed within 1,5 years from study inclusion start | |
Secondary | Self-reported Autism Spectrum symptom load | Score, The Autism Quotient (AQ) | Assessed within 1,5 years from study inclusion start | |
Secondary | Self-reported Schizotypia symptom load | Score, Schizotypal Personality Questionnaire (SPQ) | Assessed within 1,5 years from study inclusion start | |
Secondary | Self-reported well-being | Score, World Health Organization Well-Being Index (WHO-5) | Assessed within 1,5 years from study inclusion start |
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