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Atrophy clinical trials

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NCT ID: NCT03421977 Active, not recruiting - Clinical trials for Spinal Muscular Atrophy 1

Long-Term Follow-up Study for Patients From AVXS-101-CL-101

START
Start date: September 21, 2017
Phase:
Study type: Observational

This is a long term, safety follow up study of patients in the AVXS-101-CL-101 gene replacement therapy clinical trial for SMA Type 1 delivering onasemnogene abeparvovec-xioi. Patients will roll over from the parent study into this long-term study for continuous safety monitoring for up to 15 years.

NCT ID: NCT03392324 Active, not recruiting - Clinical trials for Dry Age-related Macular Degeneration

PRIMA US-Feasibility Study in Atrophic Dry AMD

PRIMA-FS-US
Start date: April 26, 2018
Phase: N/A
Study type: Interventional

In this early feasibility trial the safety and performance of the new retinal prothesis PRIMA is tested in five subjects suffering from atrophic dry age related macular degeneration.

NCT ID: NCT03197103 Active, not recruiting - Graft Loss Clinical Trials

The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction

Start date: July 4, 2017
Phase: Phase 4
Study type: Interventional

The aim of this study is to assess the effect of new tumescent solution for liposuction containing N-Acetylcysteine (Pietruski solution) on the autologous fat graft volumetric retention used for healthy women breast asymmetry correction by means of lipofilling.

NCT ID: NCT03107884 Active, not recruiting - Insulin Resistance Clinical Trials

Role of Metformin on Muscle Health of Older Adults

Start date: August 1, 2019
Phase: Early Phase 1
Study type: Interventional

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.

NCT ID: NCT03067857 Active, not recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease

Start date: September 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Herein, the investigators study the safety and efficacy of transplanting purified autologous bone marrow-derived stem cells transplanted via the intrathecal route by interventional radiology and the intravenous route.

NCT ID: NCT03054168 Active, not recruiting - Sarcopenia Clinical Trials

Systemic Hormones and Muscle Protein Synthesis

Start date: December 15, 2016
Phase: Phase 3
Study type: Interventional

This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.

NCT ID: NCT03032172 Active, not recruiting - Clinical trials for Spinal Muscular Atrophy

A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy

Jewelfish
Start date: March 3, 2017
Phase: Phase 2
Study type: Interventional

This is a multi-center, exploratory, non-comparative, and open-label study to investigate the safety, tolerability, PK, and PK/PD relationship of risdiplam in adults, children and infants with Spinal Muscular Atrophy (SMA) previously enrolled in Study BP29420 (Moonfish) with the splicing modifier RO6885247 or previously treated with nusinersen, olesoxime or AVXS-101.

NCT ID: NCT02912130 Active, not recruiting - Sarcopenia Clinical Trials

Exercise and Nutrition Interventions in Age-related Sarcopenia

Start date: September 2016
Phase: N/A
Study type: Interventional

This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia.

NCT ID: NCT02810184 Active, not recruiting - Clinical trials for Severely Atrophic Jaw

Determination of Bone Volume Changes of the Cranial Bone-augmented Jaw: A Feasibility Study

VOLCRAN
Start date: June 2016
Phase:
Study type: Observational

The investigators aim to determine the level of total bone volume remodeling at 6, 24 and 36 months post-surgery in patients who underwent immediate prosthetic rehabilitation through a cranial bone-grafted maxilla in combination with immediate provisional implant (IPI) placement.

NCT ID: NCT02782949 Active, not recruiting - Clinical trials for Chronic Atrophic Gastritis

Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

Start date: April 4, 2017
Phase: Phase 2
Study type: Interventional

This randomized phase IIb trial studies how well curcumin works in preventing gastric cancer in patients with chronic atrophic gastritis and/or gastric intestinal metaplasia. Curcumin is an antioxidant compound found in plants that may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.